Article
Oncology
Federica Cerri, Francesco Gentile, Ferdinando Clarelli, Silvia Santoro, Yuri Matteo Falzone, Giorgia Dina, Alessandro Romano, Teuta Domi, Laura Pozzi, Raffaella Fazio, Paola Podini, Melissa Sorosina, Paola Carrera, Federica Esposito, Nilo Riva, Chiara Briani, Tiziana Cavallaro, Massimo Filippi, Angelo Quattrini
Summary: This study investigates the molecular pathways underlying neurolymphomatosis (NL) by combining clinical and neuropathological investigation with gene expression studies. The results reveal the diverse neuropathic manifestations in NL patients and identify genes associated with ribosomal proteins and olfactory receptors signaling pathways. The findings provide insights into the pathogenesis and potential clinical biomarkers of NL.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Ling Yi Lee, Cheng Yin Tan, Kum Thong Wong, Khean Jin Goh, Nortina Shahrizaila
Summary: This study aimed to evaluate the diagnostic yield of nerve biopsies in patients with peripheral neuropathies. A total of 107 nerve biopsies were analyzed, and 68 (63%) were determined to have diagnostic value. Vasculitis and amyloidosis were the most common diagnoses identified through nerve biopsy. The diagnostic value of nerve biopsies in the evaluation of patients with peripheral neuropathy is limited, except for vasculitis and amyloidosis.
JOURNAL OF CLINICAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Angela Puma, Nicolae Grecu, Luisa Villa, Catherine Butori, Thomas Besson, Chiara Cambieri, Michele Cavalli, Nicolas Azulay, Sabrina Sacconi, Charles Raffaelli
Summary: This study compared ultra-high-frequency ultrasound (UHF-US) with histologic findings in progressive polyneuropathies, demonstrating that UHF-US can accurately identify nerve inflammation in neuropathies and provide valuable information.
Article
Clinical Neurology
Stefano Pro, Alberto Eugenio Tozzi, Adele D'Amico, Michela Catteruccia, Claudio Cherchi, Massimiliano De Luca, Francesco Nicita, Daria Diodato, Renato Cutrera, Enrico Bertini, Massimiliano Valeriani
Summary: The study found that in SMA 1 patients, SNAP amplitudes of the sural and median nerves decrease with age, but remain normal in younger patients, while an axonal neuropathy appears in older patients.
Article
Endocrinology & Metabolism
Raffaele Galiero, Dario Ricciardi, Pia Clara Pafundi, Vincenzo Todisco, Gioacchino Tedeschi, Giovanni Cirillo, Ferdinando Carlo Sasso
Summary: The study aimed to assess the ability of whole plantar nerve in early diagnosis of diabetic peripheral neuropathy. ROC curve analysis identified potential cut-offs for different age groups, confirming the reliability and accuracy of WPN conduction study in PN-T2DM diagnosis.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Clinical Neurology
Antony Winkel, Mark Cook, Leslie Roberts
Summary: This article evaluates the effects of different stimulation distances on the sural and superficial fibular nerves in healthy individuals, and provides the optimal electrodiagnostic information through improved techniques. The results indicate that a 10 cm stimulation distance is optimal for both nerves, with lower false-negative rates and higher amplitudes.
Article
Clinical Neurology
Roshan Dhanapalaratnam, Tushar Issar, Ann M. Poynten, Kerry-Lee Milner, Natalie C. G. Kwai, Arun Krishnan
Summary: This study found that peripheral nerve ultrasound can serve as a marker for the presence and severity of peripheral neuropathy in type 2 diabetes, with high sensitivity and specificity. The tibial nerve CSA correlates with neuropathy severity.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Diogo Costa Garcao, Maria Stephany de Souza Paiva, Karolaine Santos Corcinio
Summary: This study investigates variations in the formation and course of the sural nerve. The formation of the sural nerve was classified into eight different patterns, with type 4 being the most common. The study also found a correlation between gender and the formation pattern of the sural nerve, but no association between laterality of the lower limbs. The sural nerve or its branches mainly crossed from the medial aspect of the leg to the lateral margin of the calcaneal tendon.
NEUROSURGICAL REVIEW
(2023)
Review
Biochemistry & Molecular Biology
Lars B. Dahlin
Summary: Appropriate animal models are crucial for studying the biology and physiology of neurons and other cells under normal and stress conditions. Understanding the activation of genes and factors in nerve regeneration is important for conditions like nerve injuries and neuropathy. Advanced technology and bioinformatics are necessary for a comprehensive understanding of different cell types and their behavior in neuropathies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
G. H. Shamsaei, M. Zakerkish, D. Kashipazha, M. Moradi, H. Zakizadeh
Summary: Diabetic neuropathy is a common and harmful complication of diabetes mellitus. Early detection and prevention of polyneuropathy in diabetic patients is important. A cross-sectional study was conducted on consecutive patients with type 2 diabetes mellitus in Iran, using the Nihon Kochden gadget to measure nerve amplitudes. The findings suggest that the sural/radial nerve amplitude ratio is a promising method for detecting neuropathy in patients with type 2 diabetes.
NEW ARMENIAN MEDICAL JOURNAL
(2023)
Article
Clinical Neurology
Nathalie Deschamps, Stephane Mathis, Mathilde Duchesne, Karima Ghorab, Gael Gallouedec, Laurence Richard, Jean-Marc Boulesteix, Philippe Corcia, Laurent Magy, Jean-Michel Vallat
Summary: CIDP is an immune-mediated disease that may be associated with various hemopathies. This study analyzed 21 patients with both CIDP and hemopathies, all of whom fulfilled the diagnostic criteria for CIDP and had compatible nerve biopsy results. It is important to consider CIDP in cases of peripheral neuropathy and malignant hemopathy, as CIDP is accessible to appropriate therapies with potential positive clinical responses. Collaboration between neurologists, hematologists, and oncologists is crucial for the management of such patients.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Tushar Issar, Shyam S. Tummanapalli, Adeniyi A. Borire, Natalie C. G. Kwai, Ann M. Poynten, Ria Arnold, Maria Markoulli, Arun V. Krishnan
Summary: Participants with diabetes and metabolic syndrome showed more severe alterations in peripheral nerve structure and function compared to those with diabetes alone, likely due to reduced function of the sodium-potassium pump.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Qixing Hu, Guilin Li
Summary: Diabetic cardiac autonomic neuropathy is a serious complication of diabetes that affects the sympathetic and parasympathetic nerves. Purinergic receptors play a crucial role in this process. A study summarized in this paper explores the abnormal changes in sympathetic nerve function in diabetes and highlights the significance of targeting purinergic receptors for the treatment of diabetic autonomic neuropathy.
Review
Clinical Neurology
Dev Nathani, Judith Spies, Michael H. Barnett, John Pollard, Min-Xia Wang, Claudia Sommer, Matthew C. Kiernan
Summary: Nerve biopsy is a crucial step in evaluating patients with neuropathic symptoms, but not all patients receive a definitive pathological diagnosis, highlighting the importance of appropriate patient selection and techniques. In addition to nerve biopsy, concurrent muscle and skin biopsies may enhance diagnostic yield in certain cases. Recent advancements in diagnostics, particularly in genomics, have influenced the changing indications for nerve biopsy.
Article
Multidisciplinary Sciences
Eva Placheta-Gyoerl, Lea Maria Brandstetter, Jakob Zemann-Schaelss, Sonja Wolf, Christine Radtke
Summary: This study showed significant axonal loss, impaired myelination, and dysfunction of Schwann cells in patients with polyneuropathy compared to healthy controls. The phenotypic alterations of Schwann cells were similar to those seen after peripheral nerve injury, indicating the clinical relevance of Schwann cell dysfunction.
