Article
Medicine, General & Internal
Jiahao Su, Yichun Xing, Sitao Liang, Qichang Lin, Huijiao Liu
Summary: This study showed that the transcortical approach for ventricular hemorrhage compared with EVD improved the hematoma clearance rate, shortened catheterization time, reduced the incidence of postoperative hydrocephalus, decreased patient mortality, led to a better prognosis, and reduced complications of hydrocephalus.
Article
Clinical Neurology
Xiao Rao, Jiaqi Zhang, Kuangyang Yu, Yuxuan Sun, Jian Zhou, Lu Jiang, Tianjie Liu, Bingqing Xie, Jianhua Peng, Yong Jiang
Summary: This study aimed to evaluate the effect of early external ventricular drainage (EVD) on functional recovery in patients with intracerebral hemorrhage and intraventricular hemorrhage. The results showed that the rate of favorable outcome at 3 months was higher in the early EVD group, and the early EVD group had significantly smaller peak perihemorrhagic edema (PHE) volumes and lower incidence of postoperative infections compared to the routine EVD group.
WORLD NEUROSURGERY
(2023)
Article
Neurosciences
Sung Ho Jang, Jong Hoon Kim, Hyeok Gyu Kwon, Min Son Kim
Summary: This study investigated prefronto-thalamic tract injuries in stroke patients using diffusion tensor tractography, and found that patients who underwent EVD of the affected hemisphere showed better cognitive outcomes compared to patients who underwent EVD through the unaffected hemisphere or through both hemispheres.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Ao Chen, JianXian Li, Hao Luo, Tao Sun, RenHui Zhou, Rong Xiang, ZhongChi Tong
Summary: This study aimed to determine whether EVD is beneficial in patients with mild IVH. Data from IVH patients treated conservatively or with EVD were analyzed retrospectively. The primary outcome was poor functional status at 90 days, and secondary outcomes included mRS score distribution, clot resolution time, and complications. No evidence supports that preventive EVD benefits patients with mild IVH.
NEUROSURGICAL REVIEW
(2023)
Review
Clinical Neurology
Cheng Yang, Zhulin Zhang, Rongjie Liao, Yuhong Li
Summary: This study analyzed the relationship between preoperative external ventricular drainage (preop-EVD) and preoperative rebleeding in aneurysmal subarachnoid hemorrhage. The results showed that preop-EVD does not significantly increase the risk of preoperative rebleeding prior to aneurysm repair. Patients with poorer clinical status on admission and aneurysms larger than 1 cm are more likely to experience preoperative rebleeding.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Anesthesiology
Katharina Platzbecker, Stephanie D. Grabitz, Dana Raub, Maira I. Rudolph, Sabine Friedrich, Nathan Vinzant, Tobias Kurth, Christian Weimar, Deepak L. Bhatt, Ala Nozari, Timothy T. Houle, Xinling Xu, Matthias Eikermann
Summary: The study aimed to develop and validate a prognostic model for identifying high-risk patients of postoperative ischaemic stroke within 1 year after surgery. A hospital registry study was conducted on adult patients undergoing noncardiac surgery between 2005 and 2017 in two healthcare networks in Massachusetts, USA. The final model included 13 variables and showed positive net benefits in decision curve analysis.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Critical Care Medicine
Kun He Lee, Vasileios-Arsenios Lioutas, Sarah Marchina, Magdy Selim
Summary: This study found that an early increase in ventricular size is independently associated with lower odds of good clinical outcome in the context of intracerebral hemorrhage, while measures of perihematomal edema (PHE) were not significantly associated with outcome.
NEUROCRITICAL CARE
(2022)
Article
Clinical Neurology
Heping Zhou, Zhengjiang Cha, Lei Wang, Min Chen, Qingchao Zhang, Jian Tang
Summary: This study summarizes and analyzes the clinical efficacy and safety of neuroendoscopic surgery (NES) in the treatment of patients with severe thalamic hemorrhage with ventricle encroachment (THVE). The results showed that compared to traditional extraventricular drainage (EVD), patients in the NES group had shorter hospital stays, higher Glasgow coma scale (GCS) scores, lower incidence of intracranial infections, higher hematoma clearance rate and better prognosis.
NEUROSURGICAL REVIEW
(2022)
Article
Clinical Neurology
Raywat Noiphithak, Thapakorn Phumichard, Warot Ratanavinitkul, Pataravit Rukskul
Summary: The diameter of posttreatment temporal horn and the degree of IVH reduction were significant predictors of shunt dependency in patients with IVH. Early conversion from EVD to ventriculoperitoneal shunt is safe and feasible.
WORLD NEUROSURGERY
(2023)
Review
Biochemistry & Molecular Biology
Maged Kharouba, Dimple D. Patel, Rami H. Jaber, Sherif Hanafy Mahmoud
Summary: Metabolomics is the study of metabolites in biological matrices using high-throughput profiling. It has been traditionally used to identify biomarkers for disease diagnosis and pathophysiology. However, current evidence suggests limited utility due to inconsistencies and a lack of reproducible data. Future research should focus on addressing these gaps and reproducing data on the use of specific metabolite panels.
Article
Critical Care Medicine
Michael E. Reznik, Seth A. Margolis, Scott Moody, Jonathan Drake, Geoffrey Tremont, Karen L. Furie, Stephan A. Mayer, E. Wesley Ely, Richard N. Jones
Summary: This study developed a delirium screening tool specifically for neurocritical care patients and tested its usability and accuracy. The tool showed high sensitivity and specificity in detecting delirium.
NEUROCRITICAL CARE
(2023)
Review
Clinical Neurology
Mette Haldrup, Rares Miscov, Niwar Mohamad, Mads Rasmussen, Stig Dyrskog, Claus Ziegler Simonsen, Mads Gronhoj, Frantz Rom Poulsen, Carsten Reidies Bjarkam, Birgit Debrabant, Anders Rosendal Korshoj
Summary: This review and meta-analysis evaluate the effects of external ventricular drainage (EVD) and intraventricular fibrinolysis (IVF) on complications and clinical outcomes of intraventricular hemorrhage (IVH) treatment. The results show that antibiotic-coated catheters are more effective in preventing infection compared to tunnelled/uncoated catheters, and rifampicin-coated catheters are more effective than silver-impregnated catheters. IVF promotes hematoma clearance, reduces mortality, improves functional outcomes, and decreases the rate of catheter occlusion.
WORLD NEUROSURGERY
(2023)
Review
Clinical Neurology
A. Aravin Kumar, Jia Xu Lim, Ramesh Bakthavachalam, Justin R. X. Ker
Summary: This article presents a novel non-invasive 'pressure differential efflux technique' for successfully managing bilateral air locked EVD. It utilizes the pressure gradient established by adjusting each EVD to a different height to evacuate the pneumoventricle. Additionally, a sequential approach to the management of EVD malfunction based on the current literature and institutional protocol is introduced.
JOURNAL OF CLINICAL NEUROSCIENCE
(2022)
Review
Clinical Neurology
Nebojsa Lasica, Vidak Raicevic, Nikola M. Stojanovic, Djula Djilvesi, Igor Horvat, Bojan Jelaca, Filip Pajicic, Petar Vulekovic
Summary: Metabolomics has become a useful tool in studying metabolite interactions and can be applied in clinical settings for diagnostics. This article provides an overview of analytical techniques in metabolomics and focuses on its application in studying brain metabolism and cerebrovascular diseases, particularly aneurysmal subarachnoid hemorrhage. Both animal models and human studies are considered, and potential biomarkers are highlighted.
FRONTIERS IN NEUROLOGY
(2023)
Editorial Material
Clinical Neurology
Emanuele La Corte, Micol Babini, Mariella Lefosse, Francesca Nicolini, Mino Zucchelli
Summary: Intraventricular hemorrhage and subsequent post hemorrhagic hydrocephalus are serious complications in premature infants, leading to neurodevelopmental delay, epilepsy, and cognitive impairment. Temporary cerebrospinal fluid diversion procedures may be a therapeutic option for such infants.
WORLD NEUROSURGERY
(2021)
Editorial Material
Clinical Neurology
Niklas Marklund
ACTA NEUROCHIRURGICA
(2019)
Article
Biochemistry & Molecular Biology
Ilknur Ozen, Karsten Ruscher, Robert Nilsson, Johanna Flygt, Fredrik Clausen, Niklas Marklund
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Sport Sciences
Fredrik Vedung, Sofie Hanni, Yelverton Tegner, Jakob Johansson, Niklas Marklund
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2020)
Review
Clinical Neurology
Nikolaos Saridakis, Christina Koumantzia, Sylwia Libard, Niklas Marklund, Andreas Eleftheriou
CLINICAL NEUROLOGY AND NEUROSURGERY
(2020)
Review
Clinical Neurology
Sami Abu Hamdeh, Olli Tenovuo, Wilco Peul, Niklas Marklund
Summary: Omics technology can improve TBI diagnosis, prognosis, and understanding of injury mechanisms, with the potential for precision medicine and personalized therapeutic interventions in the future.
ACTA NEUROCHIRURGICA
(2021)
Article
Biochemistry & Molecular Biology
Daniela Talhada, Niklas Marklund, Tadeusz Wieloch, Enida Kuric, Karsten Ruscher
Summary: The study demonstrates that dopaminergic treatment combined with rehabilitative training enhances long-term recovery after stroke and results in increased dopaminergic innervation in the animals post-stroke. Furthermore, treatment with levodopa was shown to significantly downregulate the Nogo A pathway, promoting structural plasticity in the infarcted area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Georgy Bakalkin, Olga Nosova, Daniil Sarkisyan, Mathias Hallberg, Mengliang Zhang, Jens Schouenborg, Niklas Marklund, Hiroyuki Watanabe
Summary: Traumatic brain injury and controlled cortical impact (CCI) caused asymmetry in posture in rats, with left side injuries unexpectedly resulting in flexion on the left hindlimb. The effects on hindlimb postural asymmetry were not mirror-symmetrical between the left and right CCI, suggesting differences in neural pathways between the two types of injuries.
EXPERIMENTAL BRAIN RESEARCH
(2021)
Article
Critical Care Medicine
Jakob Winberg, Isabella Holm, David Cederberg, Malin Rundgren, Erik Kronvall, Niklas Marklund
Summary: This study implemented structured cerebral microdialysis (CMD) monitoring in SAH patients and found that CMD monitoring can contribute to active interventions and improve the management of SAH patients. The majority of energy metabolic disturbances were actively intervened based on CMD monitoring, and a low incidence of delayed cerebral ischemia (DCI) was observed.
NEUROCRITICAL CARE
(2022)
Article
Medicine, General & Internal
Francesco Latini, Markus Fahlstrom, David Fallmar, Niklas Marklund, Janet L. Cunningham, Amalia Feresiadou
Summary: This study investigates white matter abnormalities in early post-COVID-19 encephalitis using diffusion tensor imaging (DTI). The results show that DTI is more sensitive than standard MRI in detecting early white matter changes, indicating its potential value in diagnosing and making therapeutic decisions for COVID-19-related neurological symptoms.
UPSALA JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Clinical Neurology
Parmenion P. Tsitsopoulos, Stefania Mondello, Ulrika Holmstrom, Niklas Marklund
Summary: This study evaluated cerebrospinal fluid (CSF) biomarkers in patients with degenerative cervical spondylotic myelopathy (DCM) and found that CSF biomarker levels can reflect the severity of preoperative neurological status, correlate with radiological appearance, and correlate with clinical outcome. These findings suggest that CSF biomarkers may be a useful tool for assessing DCM severity and predicting outcomes after surgery.
Editorial Material
Clinical Neurology
Niklas Marklund
Article
Health Care Sciences & Services
Harry Mee, Ana M. Castano-Leon, Ivan Timofeev, Amos Adeleye, Indira Devi Bhagavatula, Niklas Marklund, Susanne Muehlschlegel, Katie Bond, Clare Clement, Kirsty Grieve, Nicola Owen, Gemma Whiting, Carole Turner, Andres Mariano Rubiano Escobar, Dhaval Shukla, Maria Paul, Judith Allanson, Valerie Pomeroy, Edoardo Viaroli, Elizabeth Warburton, Adam Wells, Gregory Hawryluk, Adel Helmy, Fahim Anwar, Stephen Honeybul, Peter Hutchinson, Angelos Kolias
Summary: The study aims to establish a standardized core outcome set (COS) for cranioplasty in traumatic brain injury (TBI) and stroke patients. Data will be collected through systematic review and qualitative study, followed by Delphi survey and consensus meetings for COS development. The study is expected to be completed by the end of 2022 or the beginning of 2023.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Immunology
Anna Gard, Fredrik Vedung, Fredrik Piehl, Mohsen Khademi, Maria Portonova Wernersson, Ia Rorsman, Yelverton Tegner, Helene Pessah-Rasmussen, Karsten Ruscher, Niklas Marklund
Summary: A sports-related concussion (SRC) often leads to shearing and stretching of axons in the white matter, causing secondary inflammatory processes and persistent post-concussive symptoms (PPCS). In this study, athletes with PPCS showed signs of ongoing neuroinflammation, as indicated by altered profiles of cerebrospinal fluid (CSF) biomarkers. The findings suggest the importance of studying treatments targeting the post-injury inflammatory response in sports-related concussion.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Neuroimaging
Niklas Marklund, Fredrik Vedung, Mark Lubberink, Yelverton Tegner, Jakob Johansson, Kaj Blennow, Henrik Zetterberg, Markus Fahlstrom, Sven Haller, Staffan Stenson, Elna-Marie Larsson, Anders Wall, Gunnar Antoni
Summary: Using PET, increased tau aggregation and neuroinflammation were observed in young adult TBI patients and rSRC athletes at over 6 months post-injury. Lower RBANS cognitive evaluation scores, increased NF-L levels, and lower serum tau levels were found in both groups.
NEUROIMAGE-CLINICAL
(2021)
Article
Clinical Neurology
Sami Abu Hamdeh, Erik Rollman Waara, Christer Moller, Linda Soderberg, Hans Basun, Irina Alafuzoff, Lars Hillered, Lars Lannfelt, Martin Ingelsson, Niklas Marklund