Article
Multidisciplinary Sciences
Aravinthan Varatharaj, Roxana O. Carare, Roy O. Weller, Mary Gawne-Cain, Ian Galea
Summary: The study reveals a drainage pathway in the human brainstem through which interstitial fluid can drain into the adjacent trigeminal and oculomotor nerves, suggesting a communication pathway between the extracellular spaces of the brainstem and cranial nerve parenchyma.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Anatomy & Morphology
Vlad Tereshenko, Udo Maierhofer, Dominik C. Dotzauer, Gregor Laengle, Olga Politikou, Genova Carrero Rojas, Christopher Festin, Matthias Luft, Florian J. Jaklin, Laura A. Hruby, Andreas Gohritz, Dario Farina, Roland Blumer, Konstantin D. Bergmeister, Oskar C. Aszmann
Summary: Basic behaviors such as swallowing, speech, and emotional expressions involve the coordinated control of multiple head muscles. This study investigated the neural components responsible for motor control of facial, masticatory, and tongue muscles in humans. The findings suggest that facial expressions and tongue movements require a larger population of motor axons compared to muscles in the upper extremity. Sensory axons are involved in providing neural feedback for control of facial and tongue muscles, while sympathetic axons may play a role in involuntary muscle tone control.
FRONTIERS IN NEUROANATOMY
(2023)
Article
Anatomy & Morphology
W. Quanchareonsap, S. Jariyakosol, S. Apinyawasisuk, A. Roumwong, V. Chentanez
Summary: The microanatomy of the central myelin portion and transitional zone of the oculomotor and abducens nerves is beneficial for identifying the site of compression in neurovascular conflicts. The study provides detailed observations and measurements of these nerves, contributing to our understanding of trigeminal neuralgia and hemifacial spasm.
FOLIA MORPHOLOGICA
(2023)
Article
Clinical Neurology
Junjie Chen, Zexian Liu, Yejie Xu, Zezheng Liu, Zhiyang Zheng, Zhenfeng Zhang, Chaohui Fan, Qingchu Li, Qinghao Zhao
Summary: This study aims to investigate the anatomical characteristics of the sinuvertebral nerve (SVN) and their clinical significance. The results showed that the SVN primarily originates from the spinal nerve and/or the communicating branch and mainly innervates the posterolateral aspect of the intervertebral disc. These findings are important for understanding discogenic low-back pain and improving the effectiveness of treatments targeting the SVN.
Review
Clinical Neurology
Santiago Gutierrez, Tyler Warner, Erin McCormack, Cassidy Werner, Mansour Mathkour, Joe Iwanaga, Aysun Uz, Aaron S. Dumont, R. Shane Tubbs
Summary: This paper provides a comprehensive review of syndromes associated with the lower cranial nerves, discussing anatomy and historical contributors. It highlights subtle differences among these syndromes and symptoms and signs of LCN lesions. Effective treatments are available, but correct and swift diagnosis is crucial for complete recovery.
NEUROSURGICAL REVIEW
(2021)
Article
Neurosciences
Soo Ji Sirh, So Woon Sirh, Hah Yong Mun, Heon Man Sirh
Summary: This study evaluated an integrative treatment strategy for subacute and chronic tinnitus by stimulating the trigeminal and facial nerves. The results showed that over 87.5% of patients had a significant reduction or disappearance of tinnitus after treatment, and the benefits were maintained after treatment cessation and at the 1-year follow-up.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Anatomy & Morphology
Kwang Ho Cho, Yohei Honkura, Ji Hyun Kim, Shogo Hayashi, Kei Kitamura, Gen Murakami, Jose Francisco Rodriguez-Vazquez
Summary: The topographical relationships among the lower cranial nerves, internal carotid artery (ICA), and internal jugular vein (IJV) in the upper parapharyngeal neurovascular bundle were examined in this study.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2023)
Review
Otorhinolaryngology
Hussein Walijee, Casey Vaughan, Nazia Munir, Ahmed Youssef, Bernhard Attlmayr
Summary: The study conducted a comprehensive literature review on the pathophysiological mechanisms and management strategies of vascular compression of the vestibulocochlear nerve. Results showed that vascular loops in the cerebellopontine angle and internal auditory meatus are common and should be considered a normal variant. Additionally, advances in anatomical understanding help explain the complexity of symptoms caused by neurovascular interaction.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Biology
Sang-Ku Park, Hyun Seok Lee, Kyung Rae Cho, Kwan Park
Summary: BAEP testing is crucial during MVD surgery for detecting vestibulocochlear nerve damage, and real-time testing is the best way to minimize this damage. Recent studies on the relationship between vestibulocochlear nerve damage and BAEP waveforms provide valuable insights.
Article
Oncology
Edinson Najera, Bilal Ibrahim, Baha'eddin A. Muhsen, Assad Ali, Clariza Sanchez, Michal Obrzut, Hamid Borghei-Razavi, Badih Adada
Summary: Cranial nerve deficits are the most common cause of disability after cavernous sinus surgery, with tumors entering the sinus through different pathways. Understanding vascular anatomy can help reduce postoperative complications.
FRONTIERS IN ONCOLOGY
(2021)
Review
Anatomy & Morphology
Elizabeth Sharp, Melissa Roberts, Agnieszka Zurada-Zielinska, Anna Zurada, Jerzy Gielecki, Richard Shane Tubbs, Marios Loukas
Summary: This study identified the most commonly injured nerves during surgery and the associated procedures, and suggested four factors that could potentially decrease the risk of iatrogenic nerve injury for all peripheral nerves.
Article
Multidisciplinary Sciences
Piotr Nowak, Lukasz Kubaszewski
Summary: This study assessed the asymmetry of the intervertebral foramina in the degenerative lumbar spine using three-dimensional imaging techniques. It found that only a small percentage of cases had symmetry in both intervertebral segments and there was no significant link between asymmetry and sex or age. This is the first study to confirm the asymmetry of the intervertebral foramina, which may be related to degenerative scoliosis. Other factors should be considered when predicting the progression and magnitude of the deformity.
Article
Clinical Neurology
Mee-Gang Kim, Eun Ah Hong, Yong Seok Nam, Jong In Lee
Summary: This study investigated the branching pattern and topographic anatomy of the nerves to the teres minor and the long head of the triceps brachii, proposing optimal needle placement points for electromyography. The teres minor is innervated by the axillary nerve in three patterns, while the long head of the triceps brachii is exclusively innervated by the radial nerve. The optimal needle insertion points were found to be the midpoint of the reference line from the acromion to the inferior angle of the scapula for the teres minor, and the one-third point of the reference line from the acromion to the medial epicondyle, or the two-thirds point of the reference line from the acromion to the axillary fold for the long head of the triceps brachii.
Article
Health Care Sciences & Services
Simeon C. C. Daeschler, Anna Pennekamp, Dimitrios Tsilingiris, Catalina Bursacovschi, Martin Aman, Amr Eisa, Arne Boecker, Felix Klimitz, Annette Stolle, Stefan Kopf, Daniel Schwarz, Martin Bendszus, Ulrich Kneser, Zoltan Kender, Julia Szendroedi, Leila Harhaus
Summary: This study aims to quantify the therapeutic effect of targeted lower extremity nerve decompression surgery on pain intensity, sensory function, motor function, and neural signal conduction in patients with preexisting painful sensorimotor diabetic neuropathy and nerve entrapment. The results indicate that surgical decompression can alleviate external strain on the affected nerve and improve symptoms, including pain and sensory dysfunction. This research is of great significance for screening and providing proper treatment to diabetic neuropathy patients with lower extremity nerve entrapment.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Shanesh Kumar, Mohammad Danish Mangi, Steven Zadow, Wanyin Lim
Summary: This article provides an overview of the anatomical course of various lower limb nerves and describes common locations and causes of nerve entrapments. It discusses the imaging options, including ultrasound and MRI, and explains the findings of nerve entrapments on these imaging modalities. It highlights the importance of imaging in diagnosing and managing entrapment neuropathies.
INSIGHTS INTO IMAGING
(2023)
Article
Neurosciences
Melina Engelhardt, Jana Kimmel, Giovanni Raffa, Alfredo Conti, Thomas Picht
Summary: The study demonstrates that accelerated low-frequency rTMS is a safe and feasible method for stimulating the motor cortex, and may make rTMS protocols more accessible to patients.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Matteo Martinoni, Giovanni Miccoli, Luca Albini Riccioli, Francesca Santoro, Giacomo Bertolini, Corrado Zenesini, Diego Mazzatenta, Alfredo Conti, Luigi Maria Cavallo, Giorgio Palandri
Summary: The aim of this study was to evaluate the neurocognitive outcome in patients with late-onset idiopathic aqueductal stenosis (LIAS) who underwent endoscopic third ventriculostomy (ETV). The results showed that ETV is a safe and effective surgical procedure for the treatment of LIAS, with improvements in neurological and neurocognitive functions observed postoperatively.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Micaela Mitolo, Matteo Zoli, Claudia Testa, Luca Morandi, Magali Jane Rochat, Fulvio Zaccagna, Matteo Martinoni, Francesca Santoro, Sofia Asioli, Filippo Badaloni, Alfredo Conti, Carmelo Sturiale, Raffaele Lodi, Diego Mazzatenta, Caterina Tonon
Summary: In patients with frontal gliomas, compensatory cortical activations were found in the non-dominant hemisphere, associated with better cognitive performance and more favorable tumor characteristics, shedding light on neuroplasticity mechanisms.
FRONTIERS IN NEUROLOGY
(2022)
Article
Surgery
Matteo Zoli, Corrado Zenesini, Gemma Bassani, Andrea Colangelo, Elad Fayel, Giullia Labanca Lima, Matteo Maestri, Giuseppe Pinto, Antonino Scibilia, Alfredo Conti, Diego Mazzatenta
Summary: Most students showed interest in neurosurgery, but also found it intimidating. The majority believed neurosurgery should be included in all students' education and that practical operating room training should involve all students. Internship and participation in meetings or seminars were considered the most effective learning methods, with online seminars also being perceived as useful.
FRONTIERS IN SURGERY
(2022)
Review
Oncology
Vincenzo Di Nunno, Mario Fordellone, Giuseppe Minniti, Sofia Asioli, Alfredo Conti, Diego Mazzatenta, Damiano Balestrini, Paolo Chiodini, Raffaele Agati, Caterina Tonon, Alicia Tosoni, Lidia Gatto, Stefania Bartolini, Raffaele Lodi, Enrico Franceschi
Summary: Artificial Intelligence (AI) has wide applications in neuro-oncology, including neuro-radiology, pathology, surgery, radiation therapy, and systemic treatments. AI can significantly reduce resources and costs while maintaining high quality standards in these fields.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Oncology
Antonio Pontoriero, Paola Critelli, Alfredo Conti, Salvatore Cardali, Filippo Flavio Angileri, Antonino Germano, Sara Lillo, Alessandro Carretta, Anna Brogna, Anna Santacaterina, Silvana Parisi, Stefano Pergolizzi
Summary: The results of this study suggest that dose escalation for high-risk WHO grade 2 meningiomas using a Combo-RT approach is safe and particularly effective in patients with subtotal resection. Further studies are needed.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Clinical Neurology
Salvatore Massimiliano Cardali, Maria Caffo, Gerardo Caruso, Gianluca Scalia, Nicola Gorgoglione, Alfredo Conti, Sergio Lucio Vinci, Valeria Barresi, Francesca Granata, Giuseppe Ricciardo, Giada Garufi, Giovanni Raffa, Antonino Germano
Summary: The proposed technique of surgical fenestration of the cisterns of the skull base appears to be effective in treating ischaemic stroke of the territory of the middle cerebral artery. The study showed a favorable functional outcome in patients after 9 months.
STROKE AND VASCULAR NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Franziska Loebel, Antonio Pontoriero, Anne Kluge, Giuseppe Iati, Gueliz Acker, Markus Kufeld, Alberto Cacciola, Stefano Pergolizzi, Sergio Vinci, Sara Lillo, Ran Xu, Carmen Stromberger, Volker Budach, Peter Vajkoczy, Carolin Senger, Alfredo Conti
Summary: Robotic radiosurgery is an effective approach for treating cerebral arteriovenous malformations (AVMs) of all Spetzler-Martin grades, with satisfactory obliteration rates, low toxicity, and a relatively rare incidence of rebleeding. Embolization before treatment can downstage the lesions and improve treatment outcomes.
Article
Clinical Neurology
Pantaleo Romanelli, Francesco Tuniz, Sara Fabbro, Giancarlo Beltramo, Alfredo Conti
Summary: This study reports the experience of using frameless LINAC SRS to treat HH-related epilepsy. The results show that this method provides good seizure control and long-term neuropsychosocial outcomes, without the risks of neurological complications associated with microsurgical resection.
FRONTIERS IN NEUROLOGY
(2022)
Review
Oncology
Vincenzo Di Nunno, Caterina Giannini, Sofia Asioli, Alfredo Conti, Julia Furtner, Damiano Balestrini, Alicia Tosoni
Summary: Only 1% of meningioma cases are classified as malignant (anaplastic) meningioma. Due to their rarity, there are gaps in the clinical management of these tumors. This review investigates the current knowledge of anaplastic meningioma in terms of pathological and radiological diagnosis, molecular assessment, and treatment approaches. Surgery and radiation therapy play a crucial role in managing grade 3 meningioma, while systemic therapy is not widely used. It is anticipated that the increasing understanding of molecular pathways will lead to the development of more effective systemic treatments.
Article
Neuroimaging
Arianna Rustici, Francesca Vari, Carmelo Sturiale, Alfredo Conti, Antonino Scibilia, Carlo Bortolotti, Raffaele Agati, Caterina Tonon, Raffaele Lodi, Diego Mazzatenta, Matteo Zoli, Ciro Princiotta, Massimo Dall'Olio, Luigi Cirillo
Summary: This study aimed to identify the angio-architectural characteristics associated with bleeding in brain arteriovenous malformations (bAVMs). The findings showed that a smaller diameter of the nidus, the absence of venous drainage alterations, and the presence of prenidal aneurysms were significantly related to the risk of bleeding in bAVMs.
NEURORADIOLOGY JOURNAL
(2023)
Article
Oncology
Gueliz Acker, Marcel Nachbar, Nina Soffried, Bohdan Bodnar, Anastasia Janas, Kiril Krantchev, Goda Kalinauskaite, Anne Kluge, David Shultz, Alfredo Conti, David Kaul, Daniel Zips, Peter Vajkoczy, Carolin Senger
Summary: Neoadjuvant stereotactic radiosurgery (NaSRS) is becoming increasingly important in the treatment of brain metastases. Our analysis showed that there was no significant difference in tumor volume pre- and postoperatively, and smaller tumors had a higher risk of volume increase. However, contouring resection cavities remains a challenge.
FRONTIERS IN ONCOLOGY
(2023)
Review
Neurosciences
Alfredo Conti, Nicola Maria Gambadauro, Paolo Mantovani, Canio Pietro Picciano, Vittoria Rosetti, Marcello Magnani, Sebastiano Lucerna, Constantin Tuleasca, Pietro Cortelli, Giulia Giannini
Summary: Modern brain atlases derived from neuroimaging and functional information are crucial for accurate neurosurgical procedures. They help avoid targeting errors caused by imaging artifacts or insufficient anatomical details.
Article
Clinical Neurology
Giorgio Palandri, Alessandro Carretta, Emanuele La Corte, Giulia Giannini, Matteo Martinoni, Paolo Mantovani, Luca Albini-Riccioli, Caterina Tonon, Diego Mazzatenta, Benjamin D. Elder, Alfredo Conti
Summary: This study aims to identify the clinical and radiological features of different forms of chronic adult hydrocephalus, and develop a scoring system for differential diagnosis.
ACTA NEUROCHIRURGICA
(2022)
Meeting Abstract
Clinical Neurology
Franziska Loebel, Carolin Senger, Gueliz Acker, Alfredo Conti, Peter Vajkoczy, Volker Budach, Nora Dengler