Article
Biophysics
Aayush Kant, Nikhil V. Medhekar, Tanmay K. Bhandakkar
Summary: The research uses a spatial calcium kinetics model to study the changes in calcium ion concentration during traumatic brain injury and finds that the critical location for primary injury may not be the most important location for secondary injury. By considering the brain tissue as a solid continuum, the study investigates the effect of dimensionality and material behavior on the correlation between stress and Ca2+ concentration.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Shotaro Michinaga, Yutaka Koyama
Summary: Traumatic brain injury (TBI) is immediate damage to the brain caused by a blow to the head, resulting in death or serious disabilities. Astrocytes play a key role in the pathogenesis of TBI, with both beneficial and detrimental effects. They are attractive targets for novel therapeutic drugs for TBI, although such drugs have not yet been developed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Taopheeq Bamidele Rabiu, Habeeb Ogundipe
Summary: This study retrospectively analyzed pediatric traumatic brain injury and found that it is a significant issue in the local setting, with a high incidence of road traffic crashes and falls as the main causes. Most cases were managed nonoperatively, and outcomes worsened with increasing severity of head injury.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Taopheeq Bamidele Rabiu, Habeeb Ogundipe
Summary: This study retrospectively analyzed pediatric traumatic brain injury (TBI) cases in a university hospital in South-West Nigeria. The study found that children accounted for a significant proportion of TBIs in the region, mainly caused by road traffic crashes and falls. Only a few patients received cranial computed tomography scans. Nonoperative care was the common management approach, and outcomes worsened with increasing severity of head injury.
WORLD NEUROSURGERY
(2022)
Article
Engineering, Biomedical
Yuhao Liu, Yongtao Lu, Yang Shao, Yanli Wu, Jintao He, Chengwei Wu
Summary: This study aims to unveil the mechanism of blast-induced traumatic brain injury (b-TBI) using the energy assessment method. Finite element (FE) models of the human head were established to simulate the shock wave in different directions. The results showed that b-TBI was caused by the combined actions of acceleration and deformation of brain tissues. The study also found that the dissipation capacity of the head was not sensitive to the impact direction.
MEDICAL ENGINEERING & PHYSICS
(2022)
Article
Clinical Neurology
Ranjit D. Singh, Jeroen T. J. M. van Dijck, Andrew I. R. Maas, Wilco C. Peul, Thomas A. van Essen
Summary: Investigating neurosurgical interventions for traumatic brain injury (TBI) involves complex challenges, including diverse patient populations, traditional eminence-based culture, limited research budgets, and life-threatening clinical settings. Statistical corrections, increased awareness of clinical equipoise, informed consent alternatives, instrumental variable analysis, and multidimensional outcome assessments are potential solutions.
WORLD NEUROSURGERY
(2022)
Review
Clinical Neurology
Jakov Tiefenbach, Hugh H. H. Chan, Andre G. G. Machado, Kenneth B. B. Baker
Summary: This article provides a comprehensive review of the current scientific evidence on the use of invasive neurostimulation for the treatment of deficits associated with traumatic brain injury (TBI). The study highlights the promising potential of neurostimulation in improving cognitive and motor functions, relieving symptoms and supporting emotional adjustment in TBI patients. However, the current literature is limited and further research is needed to identify optimal stimulation targets and paradigms, as well as to explore the impact of biological variables on treatment outcomes.
Review
Biology
Marco Aurelio M. Freire, Gabriel Sousa Rocha, Leonardo Oliveira Bittencourt, Daniel Falcao, Rafael Rodrigues Lima, Jose Rodolfo Lopes P. Cavalcanti
Summary: Traumatic brain injury (TBI) is a devastating condition that results in long-lasting morbidity and mortality. This study reviews the role of brain edema, inflammation, excitotoxicity, and oxidative stress in TBI-induced brain changes. Understanding these phenomena can improve care, rehabilitation, and quality of life for TBI patients.
Article
Clinical Neurology
Rut Thakkar, Silky Chotai, Bradley S. Guidry, Aaron Yengo-Kahn, Harrison C. Thomas, Anthony J. Sermarini, Alan R. Tang, Lola B. Chambless, Reid C. Thompson, Peter J. Morone
Summary: This study aimed to determine the impact of thrombocytopenia on preoperative hemorrhage expansion and postoperative outcomes in patients with acute subdural hematoma. The results showed that thrombocytopenia was significantly associated with expansion of hematoma preoperatively and higher in-hospital mortality in these patients.
WORLD NEUROSURGERY
(2022)
Article
Critical Care Medicine
Benjamin E. E. Zusman, Yijen Wu, Patrick M. M. Kochanek, Vincent E. E. Vagni, Keri Janesko-Feldman, Volodymyr Gerzanich, J. Marc Simard, Katherine Karahalios, Sandra Mihaljevic, Sudhanshu Raikwar, Anupama Rani, Jarrod Rulney, Shashvat M. M. Desai, Joshua Catapano, Ruchira M. M. Jha
Summary: This study evaluated the differential effects of glibenclamide on dose, TBI type, and imaging endophenotype. High-dose glibenclamide showed benefits in reducing hematoma volume, vasogenic edema, cytotoxic edema, and maintaining blood-brain barrier integrity after isolated brain contusion. However, its anti-edema effects were not robust in the presence of concomitant hemorrhagic shock.
CRITICAL CARE MEDICINE
(2023)
Article
Clinical Neurology
Cornelius K. Donat, Maria Yanez Lopez, Magdalena Sastre, Nicoleta Baxan, Marc Goldfinger, Reneira Seeamber, Franziska Muller, Polly Davies, Peter Hellyer, Petros Siegkas, Steve Gentleman, David J. Sharp, Mazdak Ghajari
Summary: The relationship between biomechanical forces and neuropathology after traumatic brain injury is crucial but poorly understood. Research suggests that mechanical strain and strain rate in the immediate aftermath of injury are significant predictors of in vivo MRI and histology changes, which can aid in predicting injury severity and guiding the development of head protection systems.
Article
Clinical Neurology
Stephane Nguembu, Yves Jordan Kenfack, Samantha Sadler, Yvan Zolo, Bello Figuim, Lorraine Arabang Sebopelo, Francklin Tetinou, Ulrick Sidney Kanmounye
Summary: This study investigated factors associated with adverse outcomes in Cameroonian patients with traumatic brain injury (TBI). It found that surgically-treated patients had a higher mortality rate compared to conservatively-treated patients after 12 days post-discharge. Overall, 66.1% of patients fully recovered, 23.4% had disabilities, and 10.5% died.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Nea Nevalainen, Teemu M. Luoto, Grant L. Iverson, Ville M. Mattila, Tuomas T. Huttunen
Summary: This retrospective study assessed the national trends of acute craniotomies following traumatic brain injury (TBI) in the Finnish adult population. The results showed a gradual decrease in the number of trauma craniotomies, but the incidence of TBI-related craniotomies remains high among geriatric patients.
ACTA NEUROCHIRURGICA
(2022)
Review
Biology
Gustavo P. Carmo, Jeroen Grigioni, Fabio A. O. Fernandes, Ricardo J. Alves de Sousa
Summary: This article aims to provide readers with a concise description of the main contributions in the field of traumatic brain injuries and neurodegenerative outcomes for women, especially related to chronic traumatic encephalopathy. It also reviews the numerical models created to address these issues and discusses the use (or lack of use) of sex-specific validation experiments. The article highlights the importance of considering sex differences in both direct injuries and the conditions that precede and follow traumatic events.
Article
Neurosciences
Jingshu Tang, Yuying Kang, Longjian Huang, Xinhong Feng, Lei Wu, Ying Peng
Summary: The study revealed that Hemocoagulase Agkistrodon (HCA) has neuroprotective effects in experimental traumatic brain injury (TBI), improving neurological deficits, reducing brain edema and hemorrhage, lowering proinflammatory cytokines while increasing anti-inflammatory cytokine levels, and diminishing BBB disruption by regulating tight junction proteins. These findings suggest the therapeutic potential of HCA in acute TBI to mitigate neuropathological damage.
BRAIN RESEARCH BULLETIN
(2021)
Article
Clinical Neurology
Teng Wang, Svein Kleiven, Xiaogai Li
Summary: This study investigates the use of novel electroosmosis based edema treatment as a complement to hyperosmotic therapy. Three electrode configurations were designed to drive excess fluid out of the edema region, with the 5-electrode design showing improved focality and directionality. The 5-electrode design is suggested to be more efficient in treating edema by driving excess fluid to surrounding normal brain where hyperosmotic therapy functions better.
ACTA NEUROCHIRURGICA
(2021)
Article
Engineering, Biomedical
Nicholas J. Cecchi, August G. Domel, Yuzhe Liu, Eli Rice, Rong Lu, Xianghao Zhan, Zhou Zhou, Samuel J. Raymond, Sohrab Sami, Heer Singh, India Rangel, Landon P. Watson, Svein Kleiven, Michael Zeineh, David B. Camarillo, Gerald Grant
Summary: This study focused on the impact exposure in high school American football athletes using the Stanford Instrumented Mouthguard technology. Statistical analysis revealed that impacts resulting in Forward head accelerations had higher magnitudes of peak kinematics and brain strain than Lateral or Rearward impacts and that athletes in skill positions sustained impacts of greater magnitude than athletes in line positions. The 95th percentile maximum principal strain was significantly lower in high school football athletes compared to collegiate football athletes, regardless of concussion history, helmet models, or varsity status.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Engineering, Biomedical
Teng Wang, Svein Kleiven, Xiaogai Li
Summary: The study proposes a novel approach for treating cerebral edema by using electroosmosis to drive edematous fluid out of the brain. The finite element head model validates the feasibility of this method and demonstrates its potential significance in improving the treatment of brain edema.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Biophysics
Madelen Fahlstedt, Shiyang Meng, Svein Kleiven
Summary: This study evaluated the influence of strain output on injury prediction and ranking. The post-processing of strain had a significant impact on injury risk functions, but had little effect on the area under the curve (AUC) value, correlation in ranking, and linear correlation. The study emphasized the importance of using the same post-processed strain for injury predictions as the one used to develop the risk function.
JOURNAL OF BIOMECHANICS
(2022)
Article
Environmental Sciences
V. S. Solbakken, S. Kleiven, M. L. Haarr
Summary: A considerable portion of marine litter pollutes coastlines around the world, and its accumulation on beaches is influenced by processes of deposition and retention that are not well understood. A study in Lofoten, Norway, found that deposition and retention vary over small spatial scales, and while there was no correlation in the timing of deposition events among different sites, there was generally stronger correlation in the timing of retention events. This highlights the importance of customizing cleanup frequency based on the spatiotemporal variation in deposition and retention for effective removal of litter from local marine environments.
MARINE POLLUTION BULLETIN
(2022)
Article
Public, Environmental & Occupational Health
Pooya Sahandifar, Christina Makoundou, Madelen Fahlstedt, Cesare Sangiorgi, Kenth Johansson, Viveca Wallqvist, Svein Kleiven
Summary: This study explores the effects of increasing rubber content on reducing the head injury risk for vulnerable road users. Experimental and modeling results show that increasing rubber content can decrease the risk of head injuries.
TRAFFIC INJURY PREVENTION
(2022)
Article
Biotechnology & Applied Microbiology
Zhou Zhou, Xiaogai Li, August G. Domel, Emily L. Dennis, Marios Georgiadis, Yuzhe Liu, Samuel J. Raymond, Gerald Grant, Svein Kleiven, David Camarillo, Michael Zeineh
Summary: Hippocampal injury is common in traumatic brain injury patients, and this study found that the adjacent fluid-containing temporal horn may exacerbate the vulnerability of the hippocampus. The presence of the temporal horn was associated with increased strain and strain rate in the hippocampus, indicating a mechanobiological dependency of the hippocampus on the temporal horn.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Songbai Ji, Mazdak Ghajari, Haojie Mao, Reuben H. Kraft, Marzieh Hajiaghamemar, Matthew B. Panzer, Remy Willinger, Michael D. Gilchrist, Svein Kleiven, Joel D. Stitzel
Summary: Head acceleration measurement sensors are widely used in contact sports to monitor head kinematic exposure. The use of validated brain models and physics-based computational simulations help translate head impact kinematics into brain mechanical responses and study injury mechanisms. This study reviews legacy and contemporary brain biomechanical models, discusses their development and validation, and recommends their use in conjunction with kinematic sensor data for understanding mTBI and subconcussions.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Correction
Engineering, Biomedical
Nicholas J. Cecchi, August G. Domel, Yuzhe Liu, Eli Rice, Rong Lu, Xianghao Zhan, Zhou Zhou, Samuel J. Raymond, Sohrab Sami, Heer Singh, India Rangel, Landon P. Watson, Svein Kleiven, Michael Zeineh, David B. Camarillo, Gerald Grant
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Biotechnology & Applied Microbiology
Svein Kleiven, Pooya Sahandifar
Summary: This study investigates the influence of trunk and pelvis angles on proximal femur forces during sideways falls. The results demonstrate that the highest forces on the femoral head are reached at specific trunk and pelvis angles.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Declan A. Patton, Reza Mohammadi, Peter Halldin, Svein Kleiven, Andrew S. McIntosh
Summary: Recent studies have shown that alpine helmets reduce the risk of focal injuries caused by radial impacts, likely due to current helmet standards that prioritize linear acceleration pass criteria. However, there is a need to evaluate their performance in more realistic snow impacts. This study developed a method to assess alpine helmets' performance for both radial and oblique impacts on snow surfaces, finding that snow sample collection time and the presence of a rotation-damping system significantly affect helmet performance.
APPLIED SCIENCES-BASEL
(2023)
Article
Biotechnology & Applied Microbiology
Xiaogai Li, Qiantailang Yuan, Natalia Lindgren, Qi Huang, Madelen Fahlstedt, Jonas Osth, Bengt Pipkorn, Lotta Jakobsson, Svein Kleiven
Summary: Finite element human body models (HBMs) are crucial for traffic safety, and developing reliable personalized HBMs is a challenging task. This study presents a new image registration-based mesh morphing method to generate personalized HBMs, which show comparable element quality to the baseline models. The method enables the comparison of HBMs and has superior geometry correction capabilities, facilitating personalized simulations.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Computer Science, Interdisciplinary Applications
Colin M. Huber, Declan A. Patton, Jalaj Maheshwari, Zhou Zhou, Svein Kleiven, Kristy B. Arbogast
Summary: Finite element (FE) modeling is used to examine the influence of repetitive head loading in sports on tissue level injury metrics. Controlled soccer headers were simulated in two directions using a human head FE model. The results showed that headers were associated with peak strains and stresses, but these values were below typical injury levels. This study provides quantitative data to understand the effects of repetitive loading on the brain.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2023)
Meeting Abstract
Biophysics
Maryam Majdolhosseini, Zhou Zhou, Svein Kleiven, Alessandra Villa
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2023)
Letter
Clinical Neurology
Svein Kleiven, Xiaogai Li, Anders Eriksson, Niels Lynoe
NEUROTRAUMA REPORTS
(2022)