The TGF-β/Smad System in IBD Pathogenesis

Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease

(2015) Giovanni Monteleone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut

(2014) R Caruso et al.   Mucosal Immunology

P056 GED-0507–34 Levo, a novel modulator of PPARgamma as new therapeutic strategy in the treatment of intestinal fibrosis

(2013) S. Speca et al.   Journal of Crohns & Colitis

A phase 1 open-label trial shows that smad7 antisense oligonucleotide (GED0301) does not increase the risk of small bowel strictures in Crohn's disease

(2012) F. Zorzi et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Tissue Inhibitor of Metalloproteinase-3 Regulates Inflammation in Human and Mouse Intestine

(2012) Ivan Monteleone et al.   GASTROENTEROLOGY

Smad7 Expression in T cells Prevents Colitis-Associated Cancer

(2011) A. Rizzo et al.   CANCER RESEARCH

Interleukin-25 production is differently regulated by TNF-α and TGF-β1 in the human gut

(2010) D Fina et al.   Mucosal Immunology

Smad3 loss confers resistance to the development of trinitrobenzene sulfonic acid-inducedcolorectal fibrosis

(2009) G. Latella et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Transforming growth factor   signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures

(2009) A Di Sabatino et al.   GUT

The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice

(2009) Jinping Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Prevention of colonic fibrosis by Boswellia and Scutellaria extracts in rats with colitis induced by 2,4,5-trinitrobenzene sulphonic acid

(2008) G. Latella et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Smad7 Controls Resistance of Colitogenic T Cells to Regulatory T Cell-Mediated Suppression

(2008) Massimo C. Fantini et al.   GASTROENTEROLOGY

Blockade of transforming growth factor   upregulates T-box transcription factor T-bet, and increases T helper cell type 1 cytokine and matrix metalloproteinase-3 production in the human gut mucosa

(2008) A. Di Sabatino et al.   GUT