Article
Gastroenterology & Hepatology
Anika Varma, Jennifer Weinstein, Jamison Seabury, Spencer Rosero, Ellen Wagner, Christine Zizzi, Elizabeth Luebbe, Nuran Dilek, Michael McDermott, John Heatwole, Lawrence Saubermann, Larissa Temple, Scott Rogoff, Chad Heatwole
Summary: This study aimed to identify the most prevalent and impactful symptoms in patients with Crohn's disease (CD) and to determine the modifying factors associated with a higher disease burden in CD.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Uma Mahadevan, Millie D. Long, Sunanda Kane, Abhik Roy, Marla C. Dubinsky, Bruce E. Sands, Russell D. Cohen, Christina D. Chambers, William J. Sandborn
Summary: The study found that exposure to biologic, thiopurine, or combination therapy during pregnancy did not increase adverse maternal or fetal outcomes, and these treatments can be continued throughout pregnancy for women with IBD to maintain disease control.
Review
Medicine, Research & Experimental
Manuel Barreiro-de Acosta, Alberto Molero, Esther Artime, Silvia Diaz-Cerezo, Luis Lizan, Hector David de Paz, Maria Dolores Martin-Arranz
Summary: This study examines the burden of inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), in Spain in terms of epidemiology, clinical manifestations, patient-reported outcomes, and economic impact. The findings show an increasing incidence of IBD in Spain, with significant impact on patients' quality of life and healthcare resources utilization.
ADVANCES IN THERAPY
(2023)
Review
Gastroenterology & Hepatology
Xiaoding Shen, Qianyi Wan, Rui Zhao, Yutao Wu, Yong Wang, Yaping Cui, Xiangnan Su, Xiaoting Wu
Summary: The umbrella review of 25 meta-analyses found that patients with inflammatory bowel diseases had a higher risk of adverse health outcomes in various aspects, but the quality of evidence was generally low. More research is needed to draw firmer conclusions.
DIGESTIVE AND LIVER DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Vishal Khatri, Ramaswamy Kalyanasundaram
Summary: This review focuses on the association between IBD and gut inflammasome, as well as recent advances in research and therapeutic strategies for IBD, discussing inflammasomes and their components, outcomes from experimental animals and human studies, inflammasome inhibitors, and developments in inflammasome-targeted therapies for IBD.
Article
Gastroenterology & Hepatology
Amy Yu, Sonia Friedman, Ashwin N. Ananthakrishnan
Summary: This study analyzed patients with pregnancy-onset IBD, and found that they were more likely to develop ulcerative colitis and had a higher risk of disease-related hospitalizations.
INFLAMMATORY BOWEL DISEASES
(2021)
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Parita Patel, Guimin Gao, George Gulotta, Sushila Dalal, Russell D. Cohen, Atsushi Sakuraba, David T. Rubin, Joel Pekow
Summary: In this study, the use of aspirin in patients with IBD did not show a significant association with hospitalization, surgery, or corticosteroid use for IBD-related complications. The findings support the safety of daily aspirin use in this population.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Shirley Cohen-Mekelburg, Xianshi Yu, Deena Costa, Timothy P. Hofer, Sarah Krein, John Hollingsworth, Wyndy Wiitala, Sameer Saini, Ji Zhu, Akbar Waljee
Summary: A national study showed evidence of variability in patient-sharing among IBD care teams, with patients at health centers with higher provider connectedness having better outcomes. Understanding provider connectedness is a step towards developing network-based interventions to enhance coordination and quality of care.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Mohammed Deputy, Kapil Sahnan, Guy Worley, Komal Patel, Violeta Balinskaite, Alex Bottle, Paul Aylin, Elaine M. Burns, Ailsa Hart, Omar Faiz
Summary: The Covid-19 pandemic has had a detrimental effect on inflammatory bowel disease (IBD) services, leading to delays in emergency care and access to investigations and surgeries. A study in England found significant decreases in hospital attendances for acute ulcerative colitis (UC) and acute Crohn's disease (CD), as well as a decrease in the volume of IBD procedures and investigations. The study also highlighted the importance of prioritizing care for patients with IBD to prevent clinical harm and a decrease in quality of life.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Silvia Salvatori, Francesco Baldassarre, Michelangela Mossa, Giovanni Monteleone
Summary: Long COVID is common in patients with inflammatory bowel diseases (IBD), with fatigue being the most frequent symptom. It does not influence the frequency of IBD relapses, but is more prevalent in female patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Thomas M. Goodsall, Tran M. Nguyen, Claire E. Parker, Christopher Ma, Jane M. Andrews, Vipul Jairath, Robert Bryant
Summary: The study systematically identified ultrasound scoring indices for assessing inflammatory bowel disease activity, with common components including bowel wall thickness, colour Doppler imaging, and bowel wall stratification. The correlation between ultrasound indices and reference standards, as well as sensitivity, specificity, accuracy, and other properties, varied within certain ranges. However, reliability and responsiveness data were limited, and most studies were rated with unclear or high risk of bias.
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Medicine, General & Internal
Katarzyna Akutko, Andrzej Stawarski
Summary: Inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the digestive tract with periods of remission and relapses. The etiopathogenesis is not fully understood, leading to only symptomatic treatment. There is a constant need to search for new high safety profile therapies for IBD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Can Lu, Josefine Schardey, Tao Zhang, Alexander Crispin, Ulrich Wirth, Konrad W. Karcz, Alexandr Bazhin, Joachim Andrassy, Jens Werner, Florian Kuehn
Summary: This study conducted a systematic review and meta-analysis to compare the survival outcomes of IBD-associated and non-IBD-associated CRC. The results showed that IBD-CRC patients had a significantly worse overall survival than those without IBD. This may be attributed to more aggressive histological characteristics and a lower rate of R0 resections at the primary tumor site.
Review
Gastroenterology & Hepatology
Shomron Ben-Horin, Lena Novack, Ren Mao, Jing Guo, Yue Zhao, Ruslan Sergienko, Jian Zhang, Taku Kobayashi, Toshifumi Hibi, Yehuda Chowers, Laurent Peyrin-Biroulet, Jean Frederic Colombel, Gilaad G. Kaplan, Min-hu Chen
Summary: Initiating biologic treatment early in the course of Crohn's disease may yield better treatment outcomes, while disease duration does not significantly impact results in ulcerative colitis.
Editorial Material
Pediatrics
Neil L. Schechter, Rachael Coakley, Samuel Nurko
Summary: This Viewpoint explores how patient and clinician expectations and biases influence feedback discussions following assessments for pediatric chronic pain.
Article
Gastroenterology & Hepatology
Julie Khlevner, Rachel Rosen, Lusine Ambartsumyan, Sarah Shrager Lusman, John M. Rosen, Desale Yacob, Hayat Mousa, Samuel Nurko, Carlo Di Lorenzo, Mary Boruta, Elyanne M. Ratcliffe, Laurence Feinstein, Julie Snyder, Richard J. Wood, Kahleb Graham, Miguel Saps, C. Prakash Gyawali, Leonel Rodriguez, Jaime Belkind-Gerson
Summary: This article discusses the commonality of neurogastroenterology and motility disorders in children and the lack of training in this area. Guidelines for training in North America are outlined, covering clinical knowledge, skills, and management elements across various anatomical regions. The aim is to break barriers to pursuing a career in NGM and provide uniform training expectations for pediatric gastroenterology fellows.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Lusine Ambartsumyan, Michele Shaffer, Kristen Carlin, Samuel Nurko
Summary: The study found that children with anorectal malformations had abnormal sensation and lower pressures longitudinally and radially along all quadrants of the anal canal. Manometric properties at rest were not associated with reported predictors of fecal continence.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Marc A. Benninga, Sunny Z. Hussain, Manu R. Sood, Samuel Nurko, Paul Hyman, Robert A. Clifford, Molly O'Gorman, Taryn Losch-Beridon, Shadreck Mareya, Peter Lichtlen, Carlo Di Lorenzo
Summary: In pediatric patients with functional constipation, lubiprostone did not show statistically significant effectiveness over placebo, but exhibited a safety profile similar to that in adults. Both doses of lubiprostone were well tolerated in children and adolescents.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jeng-Jung Chen, R. N. Kitzia Colliard, Samuel Nurko, Leonel Rodriguez
Summary: Melanosis coli is associated with the use of sennosides, but it does not affect colonic motility or increase the need for surgery in pediatric functional constipation.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Renara Natalia Cerqueira Silva, Cacilda Castelo Branco Lima, Cristiane Baccin Bendo, Luciano Rodrigues Silva Lima, Marcoeli Silva de Moura, Lucia de Fatima Almeida de Deus Moura, Marina de Deus Moura de Lima
Summary: The study revealed that severe hypomineralised second primary molars have a negative impact on the oral health-related quality of life (OHRQoL) of preschoolers and their families, but this impact is neutralised by the presence of dental caries.
INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY
(2022)
Article
Gastroenterology & Hepatology
Ricardo A. Arbizu, Maureen Amicangelo, Leonel Rodriguez, Samuel Nurko
Summary: This study investigated the changes in intra-anal pressure and characteristics of the rectoanal inhibitory reflex during anorectal manometry in patients undergoing anesthesia induction with propofol. The results showed that propofol can be used to assess the presence of the rectoanal inhibitory reflex in uncooperative children. Additionally, propofol significantly reduces resting intra-anal pressure and increases the percentage of internal anal sphincter relaxation.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Jessica L. Yasuda, Steven J. Staffa, Samuel Nurko, Madeline Kane, Stephanie Wall, Edward B. Mougey, James P. Franciosi, Michael A. Manfredi, Rachel Rosen
Summary: Regardless of the CYP2C19 metabolizer phenotype, patients with esophageal atresia (EA) are more likely to experience PPI-refractory, non-allergic esophagitis, suggesting that factors other than CYP2C19 genetics, including dysmotility, play a primary role in esophagitis in EA.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Pediatrics
Beate Beinvogl, Alexandra Cohen, Courtney DiFilippo, Madeline Kane, Samuel Nurko, Rachel Rosen
Summary: This study aimed to examine the effects of the COVID-19 quarantine on pediatric patients with aerodigestive disease, including their baseline health, medication use, health anxiety, and healthcare utilization. The results showed that despite increased health-related anxiety, patients with aerodigestive disease experienced improvements in airway symptoms and decreased medication use during the pandemic. Additionally, all patient groups continued to access healthcare despite the challenges of the lockdown.
JOURNAL OF PEDIATRICS
(2022)
Review
Gastroenterology & Hepatology
Michael Camilleri, Samuel Nurko
Summary: Bile acids play a central role in the diagnosis of BAD, with idiopathic BAD potentially being caused by reduced synthesis of FGF-19 by the ileal mucosa or genetic variation in hepatocyte proteins. Diagnosis of BAD in adults and adolescents primarily involves serum and fecal testing.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Pediatrics
Suzanna Hirsch, Samuel Nurko, Paul Mitchell, Rachel Rosen
Summary: In a retrospective study of children prescribed prucalopride for upper GI symptoms at a single tertiary care center, 65% of patients showed symptomatic improvement at their first follow-up after prucalopride initiation. Patients with enteral tubes, pulmonary comorbidities, and neurologic comorbidities were more likely to experience improvement. Among patients with feeding difficulties, 79% showed improvements in oral or tube feeding.
Article
Dentistry, Oral Surgery & Medicine
Jessica Madeira Bittencourt, Leticia Pereira Martins, Saul Martins Paiva, Isabela Almeida Pordeus, Cristiane Baccin Bendo
Summary: The objective of this study was to identify the psychosocial factors associated with early childhood caries (ECC) and oral health-related quality of life (OHRQoL) in preschool children and their families. A population-based cross-sectional study was conducted with 533 preschool children from public and private preschools. Lower socioeconomic status and higher frequency of free sugar consumption were directly associated with a more severe stage of ECC. ECC was also associated with lower OHRQoL in both children and their families. The findings suggest that psychosocial and behavior variables can impact the severity of ECC and have a negative impact on the wellbeing of preschoolers and their families.
JOURNAL OF DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Viviane Andrade Cancio de Paula, Khawana Faker, Cristiane Baccin Bendo, Monica Almeida Tostes
Summary: The Brazilian Early Childhood Oral Health Impact Scale (B-ECOHIS) was found to be sensitive and responsive to individuals diagnosed with autism spectrum disorder (ASD) undergoing dental treatment, and dental treatment improved the oral health-related quality of life (OHRQoL) of individuals with ASD.
BRAZILIAN ORAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ramon Targino Firmino, Ana Flavia Granville-Garcia, Cristiane Baccin Bendo, Fernanda Morais Ferreira, Fernanda Ruffo Ortiz, Colman Patrick Mcgrath, Saul Martins Paiva
Summary: The authors developed a short form of the Brazilian Oral Health Literacy Assessment Task for Paediatric Dentistry (BOHLAT-P) which demonstrated good model fit and reliability, and proved to be a valid measure to assess the oral health literacy (OHL) of Brazilian parents.
BRAZILIAN ORAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Natalia Moreira Teixeira, Fabiola Galbiatti de Carvalho, Mauro Henrique Nogueira Guimaraes Abreu, Ana Clara Souza-Oliveira, Elisa Feuser, Cristiane Baccin Bendo, Carolina Castro Martins
Summary: There is a negative correlation between birth weight and the incidence of dental caries in low birth weight children. Low income and consumption of sweetened beverages are risk factors for the development of caries.
PESQUISA BRASILEIRA EM ODONTOPEDIATRIA E CLINICA INTEGRADA
(2022)