Review
Pharmacology & Pharmacy
Ramyia Elangovan, Julien Baruteau
Summary: This review summarizes the complex metabolic pathway of Vitamin B12 deficiency, describes the causes of inherited and acquired Vitamin B12 deficiency, and highlights the differences in international practice regarding prescribing Vitamin B12 replacement therapy. Furthermore, the review discusses the evidence supporting novel modes of B12 replacement such as sublingual, intranasal, and subcutaneous routes, and compares them to intramuscular and oral routes in terms of patient compliance and cost-saving.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Katherine M. C. Totten, Scott A. Cunningham, Naomi M. Gades, Athema Etzioni, Robin Patel
Summary: This study investigated the pharmacokinetic properties of Staphylococcus aureus phage K after intravenous and intra-articular administration, and found that intra-articularly administered phage can enter the systemic circulation and be detected in synovial fluid for a period of time. These findings are important for the design of phage therapy experiments and therapeutic drug monitoring in preclinical and human phage studies.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Zane Temova Rakusa, Robert Roskar, Neal Hickey, Silvano Geremia
Summary: Vitamin B-12, an essential micronutrient, is dependent on dietary sources and is commonly supplemented through food. This article provides an overview of the different forms of B-12 used for supplementation, their biochemical role, bioavailability, and efficacy in various dosage forms. It also discusses the stability of these forms under different environmental factors and their quality in products on the market. The article further explores approaches to stabilize B-12, including minimizing destabilizing factors, adding stabilizers, or using innovative technological processes.
Article
Chemistry, Applied
A. Rego, I. Coelho, C. Motta, C. Cardoso, A. Gomes-Bispo, C. Afonso, N. M. Bandarra, J. A. L. Silva, I. Castanheira, J. A. M. Prates
Summary: Chub mackerel is an underutilised fish species that contains high levels of selenium and vitamin B12, which are beneficial for preventing cognitive decline and dementia. The content of these nutrients varies seasonally, emphasizing the importance of a year-round assessment to provide accurate dietary recommendations.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Urology & Nephrology
Jeremy Hardin, Henrik Galust, Richard Franklin Clark, Binh Ly, Raymond Theodore Suhandynata
Summary: Purple urine after co-administration of methylene blue and hydroxocobalamin is a rare clinical condition. The purple color is a result of combined excretion of methylene blue (blue) and hydroxocobalamin (red) in the urine, rather than a new metabolite. As the applications of hydroxocobalamin and methylene blue expand to adjunct therapies for vasoplegia, poor cardiac output, and sepsis, this phenomenon is expected to become more common.
JOURNAL OF NEPHROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Paymaan Jafar-nejad, Berit Powers, Armand Soriano, Hien Zhao, Daniel A. Norris, John Matson, Beatrice DeBrosse-Serra, Jamie Watson, Padmakumar Narayanan, Seung J. Chun, Curt Mazur, Holly Kordasiewicz, Eric E. Swayze, Frank Rigo
Summary: ASO drugs have been shown to distribute widely in the central nervous system and reduce target RNA in various types of neurons, making them suitable for treating a wide range of neurological diseases.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Veterinary Sciences
Anna Catherine Bowden, Rachel A. A. Allbaugh, Joe S. S. Smith, Jonathan P. P. Mochel, Lionel Sebbag
Summary: Ceftiofur can reach the tear compartment after a single parenterat injection and remain detectable for up to 10 days, but the concentrations are highly variable and too low to effectively combat common bacterial pathogens in dogs.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Immunology
Julia Baguna Torres, Jay Roodselaar, Megan Sealey, Marina Ziehn, Marc Bigaud, Rainer Kneuer, David Leppert, Gisbert Weckbecker, Bart Cornelissen, Daniel C. Anthony
Summary: This study investigated the distribution and efficacy of ofatumumab and ocrelizumab in huCD20 transgenic mice, revealing differences in tissue distribution patterns between subcutaneous and intravenous administration, with the possibility of more direct access to lymph nodes through the lymphatic system with subcutaneous administration. Additionally, preliminary findings suggest that ofatumumab may be more effective than ocrelizumab at controlling MS-like pathology in the brain.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
G. F. S. Teofilo, R. L. Riveros, B. B. Leme, R. S. Camargos, M. Macari, J. B. K. Fernandes, N. K. Sakomura
Summary: This study aimed to evaluate energy utilization and propose models for metabolizable and net energy requirements in broiler breeders during the egg production phase. The study found that fasting heat production remained constant throughout the production cycle, while the efficiency of energy utilization for depositing protein and fat in the body changed with the bird's age. Mixed models were proposed to accurately represent the energy requirements of broiler breeders.
Article
Chemistry, Analytical
Anastasia Korpeti, Natalia Manousi, Abuzar Kabir, Kenneth G. Furton, Paraskevas D. Tzanavaras, Constantinos K. Zacharis
Summary: In this study, a simple and rapid method combining fabric phase sorptive extraction (FPSE) and high performance liquid chromatography-ultraviolet detection (HPLC-UV) was developed for monitoring salivary vitamin B12 levels. Sol-gel Carbowax 20M coated polyester membranes were chosen for the selective extraction of the target analyte. The method showed good precision with a relative standard deviation better than 8.2% and the sol-gel Carbowax 20M coated FPSE membranes were found to be reusable for up to 25 times.
Article
Environmental Sciences
Andrii Butkovskyi, Yuying Jing, Hege Bergheim, Diana Lazar, Ksenia Gulyaeva, Sven Roar Odenmarck, Hans Ragnar Norli, Karolina M. Nowak, Anja Miltner, Matthias Kaestner, Trine Eggen
Summary: The study tested various filter material combinations suitable for retaining different pesticides and found that mixtures of pumice and vermiculite have high pesticide retention capacity and lower leaching potential, providing near natural treatment options in riparian strips.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Veterinary Sciences
Fan Yang, Chao-Shuo Zhang, Ming-Hui Duan, Han Wang, Zhe-Wen Song, Hao-Tian Shao, Kai-Li Ma, Fang Yang
Summary: The pharmacokinetics and tissue distribution of enrofloxacin were studied in Yellow River carp reared at 20 degrees C. The results showed that enrofloxacin had a wide distribution in different tissues with slow absorption and elimination in Yellow River carp.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Dario Lehoux, Adel Rafai Far, David Kallend, Peter L. J. Wijngaard, Brad Zerler
Summary: This study characterized the tissue distribution and excretion of Inclisiran in monkeys. The results showed that Inclisiran was selectively taken up by the liver, with long tissue retention. This suggests that Inclisiran's mechanism of action involves specific receptors on hepatocytes.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bogdan Mindrila, Sandra-Alice Buteica, Ion Mindrila, Dan-Eduard Mihaiescu, Marina-Daniela Manescu, Ion Rogoveanu
Summary: This study examined the influence of intravenous (IV) or intragastric (IG) administration routes on the intrahepatic distribution and therapeutic effects of iron oxide nanoparticles (IONPs). Results showed different distribution patterns of IONPs in the liver depending on the route of administration, and demonstrated the therapeutic potential of IONPs in treating anemia. Proper selection of administration routes can modulate the distribution and therapeutic effects of nanoparticles, which is important in the theragnosis of liver disease.
Article
Pharmacology & Pharmacy
Katarzyna Dettlaff, Aleksandra Gostynska, Natalia Ziolkowska, Maciej Stawny
Summary: In this study, the compatibility of KTF with eight commercial PN admixtures was investigated. The results showed that three of the mixtures were incompatible with KTF and should not be co-administered.