Journal
INFLAMMATORY BOWEL DISEASES
Volume 21, Issue 1, Pages 154-166Publisher
OXFORD UNIV PRESS INC
DOI: 10.1097/MIB.0000000000000217
Keywords
IL-17RA; IL-17; IL-25; IBD; signaling; trial
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Funding
- China Scholarship Council
- Program B for Outstanding PhD candidate of Nanjing University
- National Natural Science Foundation of China [81270478]
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Interleukin-17 receptor A (IL-17RA) is responsible for both IL-17A and IL-25 (IL-17E) signaling pathways. Current evidences suggest distinct but interactive responses between IL-17A and IL-25 signaling, both of which are critical for intestinal immune homeostasis. IL-17RA is assumed to regulate this counterbalance and therefore becomes a crucial molecule in mucosal immunology. In this review, we will describe the structure of IL-17RA, compare IL-17A and IL-25 signaling pathways, and emphasize on the function of IL-17RA in intestinal inflammation and discuss current evidences of accomplished and ongoing clinical trials with monoclonal antibodies targeting Th17 pathway, especially IL-17RA.
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