Journal
INFLAMMATION
Volume 39, Issue 2, Pages 575-582Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-015-0282-2
Keywords
gas6; acute kidney injury; sepsis; apoptosis
Categories
Funding
- National Natural Science Foundation [81401621, 81571937]
- Excellent Yong Talents Program of Traditional Chinese Medicine of Zhejiang Province [2013ZQ023]
- Zhejiang Provincial Natural Science Foundation [LY13H150004]
Ask authors/readers for more resources
Acute kidney injury (AKI) is a serious complication of sepsis, which has a high mortality rate. Growth arrest-specific protein 6 (Gas6), the protein product of the growth arrest specific gene 6, has been shown to have an anti-apoptotic effect as well as pro-survival capability. Here, we investigated the effects of Gas6 on sepsis-associated AKI in mice subjected to cecal ligation and puncture (CLP). We found that the administration of rmGas6 significantly reduced serum urea nitrogen and creatinine and improved the survival of septic mice. Furthermore, the renal pathological damage induced by CLP was attenuated by rmGas6 treatment. Finally, rmGas6 reduced the renal tissue apoptotic index and the expression of Bax, while it upregulated the expression of Bcl-2. The data suggest that rmGas6 might be used as a potential therapeutic agent for sepsis-induced AKI.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available