Article
Endocrinology & Metabolism
Fabio Bioletto, Chiara Lopez, Martina Bollati, Stefano Arata, Matteo Procopio, Federico Ponzetto, Guglielmo Beccuti, Giulio Mengozzi, Ezio Ghigo, Mauro Maccario, Mirko Parasiliti-Caprino
Summary: This study investigated the feasibility of using aldosterone-to-renin ratio (ARR) as a diagnostic criteria for primary aldosteronism (PA) in patients with resistant hypertension (RH). The results showed that in normokalemic patients, ARR had a lower diagnostic accuracy and may not accurately differentiate between PA and essential RH. However, in patients with hypokalemia, ARR had a higher diagnostic accuracy and may serve as a diagnostic criterion for PA.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jun Yang, Stella May Gwini, Lawrence J. Beilin, Markus Schlaich, Michael Stowasser, Morag J. Young, Peter J. Fuller, Trevor A. Mori
Summary: Oral contraception can increase the aldosterone to renin ratio, leading to false positive results in the screening for primary aldosteronism. Until more reliable criteria for primary aldosteronism screening in oral contraception users are established, alternative contraception methods should be considered.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Paolo Mulatero, Chiara Bertello, Franco Veglio, Silvia Monticone
Summary: Primary aldosteronism is an overlooked condition with significant mortality and morbidity. The difficulty of screening patients on antihypertensive therapy has resulted in low testing rates. However, interference with medication may not always be necessary for accurate screening.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Natalie Arnold, Iris M. Hermanns, Andreas Schulz, Omar Hahad, Volker H. Schmitt, Marina Panova-Noeva, Juergen H. Prochaska, Harald Binder, Norbert Pfeiffer, Manfred Beutel, Karl J. Lackner, Thomas Muenzel, Philipp S. Wild
Summary: This study investigates the predictive ability of direct plasma renin and aldosterone concentrations as well as their ratio (aldosterone-to-renin, ARR) for incident hypertension in the general population. The study finds that ARR has a stronger predictive value for incident hypertension than renin or aldosterone alone, especially in obese subjects.
CARDIOVASCULAR RESEARCH
(2023)
Article
Medicine, General & Internal
Tomasz Pizon, Marek Rajzer, Wiktoria Wojciechowska, Tomasz Drozdz, Dorota Drozdz, Marta Rojek, Krystian Gruszka, Danuta Czarnecka
Summary: The study aimed to assess the relations between plasma renin activity (PRA), serum aldosterone concentration (ALDO), and selected asymptomatic organ damage (AOD) indices in mild primary arterial hypertension (AH). High PRA patients had higher ALDO levels, and those with simultaneously high PRA and ARR values showed more severe arterial stiffness and renal impairment. Assessment of the influence of the renin-angiotensin-aldosterone system on AOD should consider the relationship between renin and aldosterone.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Peripheral Vascular Disease
Lebo F. Gafane-Matemane, Ruan Kruger, Wayne Smith, Catharina M. C. Mels, Johannes M. Van Rooyen, Gontse G. Mokwatsi, Aletta S. Uys, Sanette J. Brits, Aletta E. Schutte
Summary: This study showed differences in the renin-angiotensin-aldosterone system, electrolytes, blood pressure, and total peripheral resistance between healthy young Black and White adults. RAAS concentrations were found to be half in Black adults compared to White adults, but the increase in blood pressure over time was faster in Black individuals. RAAS was similar in Black and White adults only in scenarios of low Na+/K+ values, indicating a potential essential role of potassium.
Review
Physiology
Zachary Gray, Wanzhu Tu, Glenn M. Chertow, Vivek Bhalla
Summary: Aldosterone sensitivity is the response variable to a specific level of aldosterone, measured in differential tissue and blood pressure responses. This concept challenges traditional views of the renin-angiotensin-aldosterone system and may uncover novel mechanisms of hypertension, particularly in black individuals and older age groups.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Peripheral Vascular Disease
Rawan M. Alnazer, Gregory P. Veldhuizen, Peter W. de Leeuw, Abraham A. Kroon
Summary: The objective of this study is to identify the impact of age, sex, and BMI on renin, aldosterone, and the aldosterone-to-renin ratio (ARR) in hypertensive patients without primary aldosteronism. The results showed that age is the only independent determinant of the ARR, while sex and BMI do not significantly affect the ARR.
JOURNAL OF HYPERTENSION
(2023)
Review
Peripheral Vascular Disease
John W. Funder, Robert M. Carey
Summary: Primary aldosteronism, the most common secondary form of hypertension, may have a higher prevalence than previously estimated. The screening rate for primary aldosteronism is currently low, and more research is needed to explore screening and treatment methods.
Article
Peripheral Vascular Disease
Naomi D. L. Fisher, Ajay J. Kirtane, Joost Daemen, Florian Rader, Melvin D. Lobo, Manish Saxena, Josephine Abraham, Roland E. Schmieder, Andrew S. P. Sharp, Philippe Gosse, Lisa Claude, Yang Song, Michel Azizi
Summary: This study investigated the association between plasma renin and aldosterone concentrations and the blood pressure response to renal denervation. The results showed that renal denervation reduced daytime ambulatory systolic blood pressure, but renin and aldosterone concentrations did not predict the blood pressure response to renal denervation.
JOURNAL OF HYPERTENSION
(2022)
Article
Cardiac & Cardiovascular Systems
Felix Mahfoud, Raymond R. Townsend, David E. Kandzari, Kazuomi Kario, Roland E. Schmieder, Konstantinos Tsiou, Stuart Pocock, Shukri David, Kiritkumar Patel, Anjani Rao, Antony Walton, Jason E. Bloom, Thomas Weber, Markus Suppan, Lucas Lauder, Sidney A. Cohen, Pamela McKenna, Martin Fahy, Michael Boehm, Michael A. Weber
Summary: The study aimed to evaluate the impact of renal denervation (RDN) on the renin-angiotensin-aldosterone system in blood pressure regulation. Results showed that plasma renin activity and aldosterone levels significantly decreased compared to baseline in RDN patients at 3 months, with higher baseline PRA levels associated with a more significant reduction in blood pressure.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medical Laboratory Technology
Caroline Coulon, Manuela Lotierzo, Pierre Fesler, Camille Roubille, Stephanie Badiou, Anne Marie Dupuy, Jean Paul Cristol
Summary: The study demonstrates that the new aldosterone and renin immunoassays on the Lumipulse G600II(R) system show excellent analytical performance for the etiological diagnosis of secondary hypertension, with comparable clinical diagnosis results as the iSYS(R) system.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Review
Peripheral Vascular Disease
Viola Sanga, Giacomo Rossitto, Teresa Maria Seccia, Gian Paolo Rossi
Summary: This study aims to diagnose primary aldosteronism in pregnancy (PAP) and provide management suggestions based on the evidence obtained. A nomogram was developed to identify PAP cases based on the changes in aldosterone and renin. PAP cases were classified into four groups with different management and outcomes. Adrenalectomy did not improve maternal and fetal outcomes compared to medical treatment alone. Early detection and surgical treatment of unilateral PAP resulted in better outcomes for maternal hypertension and mother and baby outcomes.
Article
Medicine, General & Internal
Pan Tao, Tu Zhitao, Liu Jiming
Summary: High-dose spironolactone can significantly reduce BNP and NT-pro BNP concentrations, improve exercise tolerance, enhance clinical signs and cardiac function classification, and has better efficacy compared to low-dose spironolactone.
Review
Endocrinology & Metabolism
Huai Heng Loh, Norlela Sukor
Summary: This review aims to collate and summarize current research on the association between primary aldosteronism and obstructive sleep apnea, including their relationship, clinical characteristics, implications, treatment outcomes, potential causal links, and mechanisms.
FRONTIERS IN ENDOCRINOLOGY
(2022)