Article
Biochemistry & Molecular Biology
Yu Yin, Ruyi Xu, Lei Ning, Zhimin Yu
Summary: Diabetic retinopathy is a leading cause of blindness and visual impairment in diabetes patients. This study found that Bergenin has significant therapeutic effects on diabetic retinopathy rats.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Babiker Saad Almugadam, Peng Yang, Li Tang
Summary: The study revealed a significant decrease in richness and diversity of jejunum microbiota in T2DM, while Ceftriaxone sodium-induced gut dysbiosis reduced food-water intake and affected microbiota diversity, along with diabetic parameters.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biology
Md Fahim Ahmad, Nida Naseem, Inamur Rahman, Nazia Imam, Hina Younus, Swaroop Kumar Pandey, Waseem A. Siddiqui
Summary: This study investigated the potential use of naringin, a flavanone, in treating streptozotocin-induced diabetic neuropathy (DN) in rat models. The results showed that naringin treatment improved DN symptoms and helped restore the normal structure of the brain and pancreas tissues. The neuroprotective properties of naringin may be attributed to its ability to suppress the overactivation of inflammatory molecules and mediators of oxidative stress.
Article
Agriculture, Multidisciplinary
Chenyang Wang, Donghui Luo, Lin Zheng, Mouming Zhao
Summary: Casein hydrolysates have shown potential as anti-diabetic food, with the newly identified peptide Val-Pro-Leu-Gly demonstrating effectiveness in reducing blood glucose levels when orally administered to mice. P-FCH activates the non-insulin-mediated AMPK pathway to exert its hypoglycemic effect in diabetic rats and HepG2 cells.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Biochemistry & Molecular Biology
Maria Adhikary, Kunal Mukhopadhyay, Biswatrish Sarkar
Summary: The study found that wheatgrass, especially from the 9th day of germination, has significant antioxidant potential in reducing oxidative stress induced during diabetes. In vivo studies showed that a wheatgrass diet improved hyperglycemia, body weight, lipid profile, and antioxidant markers in diabetic rats. These findings suggest that flavonoid-rich 9th-day wheatgrass could be utilized as a functional food to control diabetes.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Jakub Michal Kurek, Ewelina Krol, Zbigniew Krejpcio
Summary: The study found that dietary supplementation with steviol glycosides can normalize lipid metabolism, alleviate internal organ damage in diabetic rats, and have no significant effect on blood glucose, insulin, and insulin resistance indices.
Article
Immunology
Anand Kumar, Priyanka Prajapati, Vinit Raj, Seong-Cheol Kim, Vikas Mishra, Chaitany Jayprakash Raorane, Ritu Raj, Dinesh Kumar, Sapana Kushwaha
Summary: This study found that salbutamol can alleviate muscle atrophy and has antioxidant and anti-inflammatory effects in streptozotocin-induced diabetic rats.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Manas Jyoti Das, Dipanjan Banerjee, Amartya Banerjee, Sangita Muchahary, Archana Sinha, Debananda Gogoi, Pronobesh Chattopadhyay, Suman Dasgupta, Sankar Chandra Deka
Summary: Lagenaria siceraria (Molina) Standl. Juice has demonstrated promising anti-inflammatory properties as well as the capacity to inhibit the digestion enzymes glucosidase and amylase, opening new avenues for further research into its antidiabetic potential.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Nutrition & Dietetics
Cristina Sanchez-Gonzalez, Lorenzo Rivas-Garcia, Alba Rodriguez-Nogales, Francesca Algieri, Julio Galvez, Pilar Aranda, Maria Montes-Bayon, Juan Llopis
Summary: The study found that diabetic rats had higher inflammatory status and lower hematological parameters, but these improved after treatment with V, with higher serum iron levels. V reduced the gene expression of hepcidin in diabetic rats, improving the anemic state caused by diabetes.
Article
Medicine, Research & Experimental
Subhash Dwivedi, Anuhya Gottipati, Raghu Ganugula, Meenakshi Arora, Richard Friend, Robert Osburne, Aline Rodrigues-Hoffman, Rita Basu, Hui-Lin Pan, M. N. V. Ravi Kumar
Summary: The study suggests that double-headed nanosystems containing curcumin (nCUR) can alleviate diabetic peripheral neuropathy (DPN) and show better outcomes when combined with long-acting subcutaneous insulin (INS). nCUR can protect nerve axons and fibers, reduce inflammation and cell death. Therefore, nCUR may be a potential treatment for DPN.
MOLECULAR PHARMACEUTICS
(2022)
Article
Food Science & Technology
Reshmi Somanathan Karthiga, Shinde Vijay Sukhdeo, Sudha Madhugiri Lakshminarayan, Shashirekha Mysuru Nanjarajurs
Summary: The study investigated the efficacy of Citrus maxima fruit segments fortified paranthas in diabetic rats. The group treated with paranthas fortified with pomelo fruit segment showed significant improvements in weight gain, plasma glucose levels, serum protein, and insulin levels compared to the diabetic control group. The antidiabetic activity was found to be more pronounced in the order of pomelo juice > fortified paranthas > naringin.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Endocrinology & Metabolism
Xudong Yang, Lifeng Wang, Liangzhi Zhang, Xia Zhai, Xiusheng Sheng, Hengjun Lin, Helong Quan
Summary: This study examined the potential of exercise in mitigating skeletal muscle atrophy induced by SGLT2i treatment and found that resistance training is more effective in increasing skeletal muscle mass and muscle fiber cross-sectional area in rats with T2DM compared to aerobic exercise.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Endocrinology & Metabolism
Ruijuan Chen, Yi Zeng, Wenbiao Xiao, Le Zhang, Yi Shu
Summary: Diabetes in elderly individuals can lead to cognitive impairment, and the mechanisms behind this are still not fully understood. Through non-targeted metabolomics using LC-MS, serum biomarkers for diabetic mild cognitive impairment in rats were identified. The study showed that Type 2 diabetes can affect various metabolic pathways, especially lipid metabolism, leading to cognitive dysfunction. Serum PE, PC, L-Trp, and S1P were identified as potential critical biomarkers for early diagnosis of DMMCI.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Natan Reyges Castro da Purificacao, Vinicius Barreto Garcia, Flavia Cristina Vieira Frez, Camila Caviquioli Sehaber, Kaio Ramon De Aguiar Lima, Marilia Fabiana de Oliveira Lima, Roseane de Carvalho Vasconcelos, Aurigena Antunes de Araujo, Juliana Vanessa Colombo Martins Perles, Jacqueline Nelisis Zanoni, Maria Luiza Diniz de Sousa Lopes, Naianne Kelly Clebis, Naianne Kelly Clebis
Summary: This study investigated the effects of antioxidant treatment on diabetic animals. The results showed that antioxidant treatment reduced symptoms such as hyperphagia and hyperglycemia, increased glutathione levels and interleukin-10 expression, and decreased collagen fiber production.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Ismet Burcu Turkyilmaz, Bertan Boran Bayrak, Ozlem Sacan, Ozgur Mutlu, Nuriye Akev, Refiye Yanardag
Summary: The study investigated the protective role of zinc on the stomach in streptozotocin (STZ)-induced diabetic rats. The results showed that zinc could reverse the abnormalities in stomach tissues caused by diabetes.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Sevim Tunali, Selda Gezginci-Oktayoglu, Sehnaz Bolkent, Ediz Coskun, Tulay Bal-Demirci, Bahri Ulkuseven, Refiye Yanardag
Summary: The study shows that VOL can reduce small intestinal injury in diabetic rats, with positive effects on biochemical indicators and a decrease in tissue damage and inflammation levels.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ismet Burcu Turkyilmaz, Bahar Bilgin Sokmen, Refiye Yanardag
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Sevim Tunali, Esra Sule Cimen, Refiye Yanardag
JOURNAL OF FOOD BIOCHEMISTRY
(2020)
Correction
Biochemistry & Molecular Biology
Sevim Tunali, Selda Gezginci-Oktayoglu, Sehnaz Bolkent, Ediz Coskun, Tulay Bal-Demirci, Bahri Ulkuseven, Refiye Yanardag
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ismet Burcu Turkyilmaz, Bertan Boran Bayrak, Ozlem Sacan, Ozgur Mutlu, Nuriye Akev, Refiye Yanardag
Summary: The study investigated the protective role of zinc on the stomach in streptozotocin (STZ)-induced diabetic rats. The results showed that zinc could reverse the abnormalities in stomach tissues caused by diabetes.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Toxicology
B. B. Bayrak, P. Koroglu, O. Karabulut Bulan, R. Yanardag
Summary: The study demonstrated that metformin has a protective effect against heart tissue damage in STZ-induced diabetic rats with Dunning prostate cancer.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ozlem Sacan, Ismet Burcu Turkyilmaz, Bertan Boran Bayrak, Ozgur Mutlu, Nuriye Akev, Refiye Yanardag
Summary: This study investigated the protective role of zinc in liver damage in streptozotocin-induced diabetes mellitus in female Swiss albino rats. The results showed that zinc administration reversed the negative effects caused by STZ-induced diabetic liver damage.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Armagan Begum Ozel, Eda Dagsuyu, Pinar Koroglu Aydin, Ilknur Bugan, Omur Karabulut Bulan, Refiye Yanardag, Aysen Yarat
Summary: This study investigated the effect of metformin on brain boron levels and oxidative brain damage in rats with diabetes and prostate cancer. The findings suggest that metformin may protect against brain damage by increasing boron levels.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Bertan Boran Bayrak, Pelin Arda-Pirincci, Sehnaz Bolkent, Refiye Yanardag
Summary: The study showed that zinc sulfate can reverse the effects of ethanol-induced cell proliferation and oxidative damage in tongue tissues of rats, indicating its therapeutic potential in such conditions.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Chemistry, Inorganic & Nuclear
Onur Ertik, Ferdane Danisman Kalindemirtas, Busra Kaya, Refiye Yanardag, Serap Erdem Kuruca, Onur Sahin, Bahri Ulkuseven
Summary: Five oxovanadium(IV) complexes were synthesized and characterized, showing cytotoxicity against MCF-7, MDA-MB-231 and 3T3 cells. The complex containing the S-propyl group exhibited the highest cytotoxicity. Additionally, the complexes inhibited elastase, xanthine oxidase, and neuraminidase enzymes, with the complexes bearing ethyl and propyl groups showing promising inhibition of neuraminidase.
Article
Toxicology
Pinar Koroglu-Aydin, Bertan Boran Bayrak, Ilknur Bugan, Omur Karabulut-Bulan, Refiye Yanardag
Summary: The study found that diabetes and cancer led to significant damage in kidney tissue, but the administration of metformin reversed these defects, indicating its potential as an adjuvant for kidney tissue damage related to diabetes, prostate cancer, and cancer therapy.
TOXICOLOGY MECHANISMS AND METHODS
(2021)
Article
Pharmacology & Pharmacy
Sevim Tunali, Refiye Yanardag
Summary: The study demonstrated that vanadyl sulfate has antioxidant properties in diabetic rats, reversing the damage caused by diabetes in various tissues.
ISTANBUL JOURNAL OF PHARMACY
(2021)
Article
Pharmacology & Pharmacy
Eda Dagsuyu, Refiye Yanardag
Summary: The study found that sulfur compounds can serve as potential inhibitors of urease and trypsin activities, with potential importance in medicine and agriculture.
ISTANBUL JOURNAL OF PHARMACY
(2021)
Article
Cell Biology
Abril Alondra Barrientos-Bonilla, Paola Belem Pensado-Guevara, Abraham Puga-Olguin, Rasajna Nadella, Aurora del Carmen Sanchez-Garcia, Laura Mireya Zavala-Flores, Arnulfo Villanueva-Olivo, Iliana Tamara Cibrian-Llanderal, Maria de Jesus Rovirosa-Hernandez, Daniel Hernandez-Baltazar
Summary: This study evaluated the impact of BrdU on liver function and found that multiple injections of BrdU did not induce hepatocellular damage.
Article
Cell Biology
Pan Zhang, Qun Feng, Wenxiao Chen, Xizhuang Bai
Summary: It was found that catalpol antagonizes LPS-mediated inflammation and suppressive osteoblast differentiation by inhibiting inflammation and promoting osteoblast differentiation. This finding contributes to a better understanding of the pathogenesis of osteoporosis.
