Journal
ACTA HISTOCHEMICA
Volume 114, Issue 8, Pages 773-778Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.acthis.2012.01.004
Keywords
beta-Catenin; Lef-1; Hair follicle; Hair follicle cycle; Mice
Categories
Funding
- China National Natural Science Foundation [30671512]
- Science and Technology Innovation Foundation of SXAU [2009001]
Ask authors/readers for more resources
It is well recognized that the Wnt pathway, in which beta-catenin and Lef-1 are important factors, is associated with many physiological processes, including embryogenesis and postnatal development. The Wnt pathway also plays a critical role in the development of skin. It regulates the formation of the dorsal dermis and epidermal appendages in the skin and the activity of epithelial stem cells. In this study, we investigated the presence and localization of beta-catenin and Lef-1 in murine hair follicles through the first postnatal month, which encompasses the first hair cycle in mice, using Western blotting and immunohistochemistry. Our results show that beta-catenin and Lef-1 are expressed during all stages in a hair cycle, most strongly in the anagen and weakly in the catagen and telogen phases. The results also suggest that the beta-catenin-Lef-1 complex may regulate hair follicle cycling. This process will be of considerable interest to future studies. (c) 2012 Elsevier GmbH. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available