Article
Developmental Biology
Abdull J. Massri, Laura Greenstreet, Anton Afanassiev, Alejandro Berrio, Gregory A. Wray, Geoffrey Schiebinger, David R. McClay
Summary: By using scRNA-seq and computational methods, researchers studied the transcriptional changes in cell states of sea urchin embryos from development to larval stage. They found that skeletogenic and primordial germ cell trajectories diverged early, and ectodermal progenitors were distinct from other lineages by the 6th cleavage. Endomesoderm cells originated at the 6th cleavage and diverged into endoderm and mesoderm fates asynchronously.
Article
Environmental Sciences
J. I. Bertucci, A. Juez, J. Bellas
Summary: The combined effects of ocean acidification and microplastic pollution on the early development of Paracentrotus lividus were studied. The results showed that both ocean acidification and microplastics can alter the growth and morphology of the embryo, with observed differences in morphology related to decreased width of larvae. The changes in larvae shape could affect their buoyancy and ability to obtain and ingest food.
Article
Chemistry, Multidisciplinary
Natalia Abramenko, Marina Semenova, Alexander Khina, Pavel Zherebin, Yurii Krutyakov, Evgeny Krysanov, Leonid Kustov
Summary: Surface modification of nanoparticles with different stabilizers is commonly used to enhance their stability and applicability. Silver nanoparticle dispersions with biologically active stabilizers show potential as plant protection products, improving crop growth, yield, and protection. However, these stabilizers exhibit toxic effects on sea urchin embryos, with silver ions being more toxic than the nanoparticles themselves.
Article
Environmental Sciences
Laura DeMiguel-Jimenez, Nestor Etxebarria, Helena C. Reinardy, Xabier Lekube, Ionan Marigomez, Urtzi Izagirre
Summary: The study utilized sea-urchin embryos as test-organisms and applied a multi-index approach to investigate the toxic effects of different oils in the environment. The findings suggest that under ice weathering resulted in lowered waterborne PAHs and genotoxicity but augmented embryo toxicity.
MARINE POLLUTION BULLETIN
(2022)
Article
Environmental Sciences
Laura DeMiguel-Jimenez, Dennis Bilbao, Ailette Prieto, Helena C. Reinardy, Xabier Lekube, Urtzi Izagirre, Ionan Marigomez
Summary: This investigation examines the influence of temperature on oil toxicity, both alone and in combination with dispersants (D). The toxicity of low-energy water accommodated fractions (LEWAF) of three oils (NNA crude oil, marine gas oil -MGO-, and IFO 180 fuel oil) produced at temperatures ranging from 5 to 25 degrees Celsius was assessed by measuring larval lengthening, abnormalities, developmental disruption, and genotoxicity in sea urchin embryos. The levels of polycyclic aromatic hydrocarbons (PAHs) were similar among LEWAFs but the PAH profiles varied with the type of oil and production temperature. The presence of dispersants increased genotoxicity, which varied depending on the LEWAF production temperature of each oil. Impaired lengthening, abnormalities, and developmental disruption were observed, with the severity of these effects depending on the type of oil, dispersant application, and LEWAF production temperature. Toxicity, partly associated with individual PAHs, was higher at lower LEWAF production temperatures.
MARINE POLLUTION BULLETIN
(2023)
Article
Toxicology
Michael D. Collins, Elvis Han Cui, Seung Won Hyun, Weng Kee Wong
Summary: The primary aim of this paper is to propose a more quantitative approach to design dose-response experiments, specifically concentration-response experiments. By using a model-based optimal design, more accurate statistical inference can be obtained for the underlying parameters of interest. The study demonstrates the efficiency gains of using a carefully selected model-based optimal design compared to an ad-hoc empirical design.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Environmental Sciences
Lisa Gaspar, Patrick Flammang, Ricardo Jose, Ricardo Luis, Patricio Ramalhosa, Joao Monteiro, Natacha Nogueira, Joao Canning-Clode, Romana Santos
Summary: Sea urchins have specialized adhesive organs called tube feet that rely on adhesive and de-adhesive secretions to attach and detach from substrates. Research has shown that other sea urchin species also possess adhesive proteins similar to those found in Paracentrotus lividus. There is high interspecific variability in the glycans involved in sea urchin adhesion, but closer taxonomic species show more conservation in this aspect.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Microbiology
Ruber Rodriguez-Barreras, Anelisse Dominicci-Maura, Eduardo L. Tosado-Rodriguez, Filipa Godoy-Vitorino
Summary: Caribbean sea urchins have experienced a decline in population. This study characterized the epibiota community associated with four wild Caribbean sea urchin species and evaluated the influence of species, trophic niches, and geographical location on the composition of the epibiotic microbiota. The results showed that the bacterial biota varied significantly among species and trophic niches, but not among geographical locations. The findings highlight the species-specific and niche-dependent nature of the epibiotic microbiota in sea urchins.
Article
Anatomy & Morphology
Victor D. Vacquier, Amro Hamdoun
Summary: The study introduces new techniques for generating parthenogenetic larvae of the Southern California sea urchin species, Lytechinus pictus. The researchers present a gallery of photomicrographs of morphologically abnormal larvae for transcriptomic analysis, aiming to compare gene expression control between parthenogenotes and fertilization-derived larvae for insights into gene regulation mechanisms in this model organism. Knowledge gained from transcriptomics of sea urchin parthenogenotes could potentially contribute to parthenogenetic studies in mammalian embryos.
DEVELOPMENTAL DYNAMICS
(2021)
Article
Environmental Sciences
Chiara Gambardella, Francesca Marcellini, Carla Falugi, Stefano Varrella, Cinzia Corinaldesi
Summary: Morphological anomalies in sea urchin early development stages are used as biomarkers in studies on environmental impact. These anomalies are influenced by the developmental stage of exposure, stress intensity, and mechanisms affected by environmental agents. Classification and analysis of these anomalies can help assess the impact of stressors on marine organisms' growth and development, and advance monitoring of coastal marine ecosystems.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Juan Bellas, Diego Rial, Juliana Valdes, Leticia Vidal-Linan, Juan Bertucci, Soledad Muniategui, Victor M. Leon, Juan A. Campillo
Summary: This study investigates the effects of three organic pollutants (chlorpyrifos, triphenyl phosphate, bisphenol A) on sea urchin larvae. The results show that chlorpyrifos has the highest toxicity, attributed to oxidative stress, modulation of acetylcholinesterase response, and reduced detoxification efficacy. The study also identifies glutathione reductase activity as a reliable biomarker of exposure for sea urchin early-life stages.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Laura DeMiguel-Jimenez, Nestor Etxebarria, Xabier Lekube, Urtzi Izagirre, Ionan Marigomez
Summary: This study assessed the toxicity of crude and bunker oils in Arctic and Sub-Arctic seas, and found that heavy bunker oil was more toxic than light crude oil, with light bunker oil in between. The dispersant was toxic and also enhanced the toxicity of the oils.
MARINE POLLUTION BULLETIN
(2021)
Article
Developmental Biology
Florence D. M. Wavreil, Jessica Poon, Gary M. Wessel, Mamiko Yajima
Summary: Differential protein regulation is critical in biological processes, and light-induced approaches can accurately control protein functions, but the efficacy needs to be tested for each system.
DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Iker Alvarez-Mora, Leire Mijangos, Naroa Lopez-Herguedas, Jose M. Amigo, Harkaitz Eguiraun, Maddi Salvoch, Mathilde Monperrus, Nestor Etxebarria
Summary: The study aims to develop a new high throughput screening method that can be used as a predictive expert system and automatically quantify the size increase and malformation of larvae, thus facilitating the use of sea urchin embryo test in complex toxicant identification pipelines such as effect-directed analysis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Developmental Biology
Wei-Lun Chang, Yi-Hsien Su
Summary: Sea urchin larval skeleton formation is regulated by HIF alpha and VEGF signaling, with HIF alpha expressed in PMCs and involved in gene expression regulation and spicule elongation.
DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Abril Alondra Barrientos-Bonilla, Paola Belem Pensado-Guevara, Abraham Puga-Olguin, Rasajna Nadella, Aurora del Carmen Sanchez-Garcia, Laura Mireya Zavala-Flores, Arnulfo Villanueva-Olivo, Iliana Tamara Cibrian-Llanderal, Maria de Jesus Rovirosa-Hernandez, Daniel Hernandez-Baltazar
Summary: This study evaluated the impact of BrdU on liver function and found that multiple injections of BrdU did not induce hepatocellular damage.
Article
Cell Biology
Pan Zhang, Qun Feng, Wenxiao Chen, Xizhuang Bai
Summary: It was found that catalpol antagonizes LPS-mediated inflammation and suppressive osteoblast differentiation by inhibiting inflammation and promoting osteoblast differentiation. This finding contributes to a better understanding of the pathogenesis of osteoporosis.
