Article
Clinical Neurology
Daiane Aparecida Spiess, Raquel Maria Pereira Campos, Luciana Conde, Nadine Didwischus, Johannes Boltze, Rosalia Mendez-Otero, Pedro Moreno Pimentel-Coelho
Summary: This study investigated the therapeutic effects of AMD3100 on neonatal hypoxic-ischemic encephalopathy (HIE) and found that it did not improve structural and functional outcomes in a rat HIE model.
Article
Quantum Science & Technology
Arne Heimendahl, Felipe Montealegre-Mora, Frank Vallentin, David Gross
Summary: The Gottesman-Knill theorem shows that a Clifford circuit can efficiently simulate stabilizer states on a classical computer. The runtime of classical simulation is determined by the stabilizer extent, and an open question remains about whether the extent is multiplicative under tensor products. This study answers this question negatively, based on general properties of stabilizer states.
Article
Endocrinology & Metabolism
Meera Mohan, Manoj Kumar, Rohan Samant, Rudy Jr Jr Van Hemert, Erming Tian, Shivang Desai, Frits van Rhee, Sharmilan Thanendrarajan, Carolina Schinke, Larry J. Suva, Shobhit Sharma, Mohamed Milad, Samantha Kendrick, Maurizio Zangari
Summary: In this study on multiple myeloma patients undergoing anti-myeloma treatment, bone remineralization was found to be associated with gene expression profile, gender, and biochemical parameters, all of which influence the treatment outcomes.
Article
Orthopedics
Tomoyuki Nakasa, Yasunari Ikuta, Junichi Sumii, Akinori Nekomoto, Shingo Kawabata, Nobuo Adachi
Summary: The clinical outcomes of osteochondral fragment fixation are superior to those of bone marrow stimulation (BMS) in osteochondral lesions of the talus (OLTs), even for smaller lesions. Fixation is recommended, especially for lesions that are more centralized on the medial and lateral sides of the talus.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Review
Orthopedics
D. A. Walsh, N. Sofat, A. Guermazi, D. J. Hunter
Summary: Assessment and treatment of Bone Marrow Lesions (BMLs) have the potential to significantly improve the lives of people with osteoarthritis (OA). This review examines the characteristics of OA-BMLs, their diagnosis and measurement, and their associations with pain and OA structural progression. The article discusses the factors contributing to BML pathogenesis and the potential of interventions targeting BMLs to reduce pain and slow down OA progression. The evaluation methods for BMLs and their usefulness in identifying individuals at risk and evaluating treatment responses are critically appraised.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Oncology
Zhi-Zhang Yang, Hyo Jin Kim, Hongyan Wu, Xinyi Tang, Yue Yu, Jordan Krull, Daniel P. Larson, Raymond M. Moore, Matthew J. Maurer, Kevin D. Pavelko, Shahrzad Jalali, Joshua C. Pritchett, Rekha Mudappathi, Junwen Wang, Jose C. Villasboas, Patrizia Mondello, Anne J. Novak, Stephen M. Ansell
Summary: T-lymphocytes in the tumor microenvironment of follicular lymphoma (FL) show diverse phenotypes, which may influence tumor biology and patient survival. Our analysis of 82 FL patients revealed four immune subgroups with different T-cell phenotypes, and a higher prevalence of CD57(+) T-FH cells with a late-stage differentiation phenotype was associated with poor patient survival.
BLOOD CANCER JOURNAL
(2023)
Article
Medicine, General & Internal
Hanna Hebelka, Helena Brisby, Alfred Erkmar, Kerstin Lagerstrand
Summary: This study investigated the effect of spinal loading on the MRI signal of Modic changes in patients with low back pain. The results showed that there were no changes in the volume or signal of Modic changes in MRI scans performed with and without spinal loading.
Article
Hematology
Abdullah Freiwan, Jaquelyn T. Zoine, Jeremy Chase Crawford, Abishek Vaidya, Stefan A. Schattgen, Jacquelyn A. Myers, Sagar L. Patil, Mahsa Khanlari, Hiroto Inaba, Jeffery M. Klco, Charles G. Mullighan, Giedre Krenciute, Peter J. Chockley, Swati Naik, Deanna M. Lang, Maksim Mamonkin, Esther A. Obeng, Paul G. Thomas, Stephen Gottschalk, Paulina Velasquez
Summary: CD7(-) T cells can serve as a promising subset for CAR-T cell therapy of T-ALL and other hematological malignancies.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ricardo Donners, Nicos Fotiadis, Ines Figueiredo, Matthew Blackledge, Daniel Westaby, Christina Guo, Maria de los Dolores Fenor de la Maza, Dow-Mu Koh, Nina Tunariu
Summary: This study aims to investigate the laboratory, imaging, and procedural factors associated with a positive tumor and/or NGS-feasible CT-guided sclerotic bone lesion biopsy result in cancer patients. The analysis of 113 CT-guided bone biopsies revealed that targeting areas with predominantly mild sclerosis in sclerotic bone lesions can improve tumor tissue yield and NGS feasibility.
EUROPEAN RADIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Sharon Grad-Akrish, Adi Rachmiel, Ofer Ben-Izhak
Summary: The study found that SATB2 is not a reliable diagnostic marker for oral osteosarcoma, but it can be useful in detecting cells with osteoblast differentiation in histologic samples. Strong SATB2 expression was observed in juvenile aggressive ossifying fibroma, while weak expression was seen in stromal spindle cells adjacent to reactive bone tissue.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2021)
Article
Anesthesiology
Christopher Centeno, Cameron Cartier, Ian Stemper, Ehren Dodson, Michael Freeman, Ugochi Azuike, Christopher Williams, Matthew Hyzy, Otono Silva, Neven Steinmetz
Summary: The study found that treating knee bone marrow lesions with either intraarticular injections of bone marrow concentrate and platelet products alone, or intraosseous plus intraarticular injections, did not significantly impact patient reported outcomes.
Article
Multidisciplinary Sciences
Meike Farber, Yiyang Chen, Lucas Arnold, Michael Moellmann, Eva Boog-Whiteside, Yu-An Lin, H. Christian Reinhardt, Ulrich Duehrsen, Maher Hanoun
Summary: Targeting the interaction between leukemic cells and the microenvironment by inhibiting CD38 has the potential to enhance therapeutic efficacy in AML. However, while the anti-CD38 antibody daratumumab showed significant cytostatic efficacy in an in vitro model, it ultimately lacked robust anti-leukemic effects in vivo in a xenograft transplantation model.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Sammy Badr, Heloise Dapvril, Daniela Lombardo, Huda Khizindar, Claire Martin, Bernard Cortet, Anne Cotten, Julien Paccou
Summary: This study aimed to investigate the relationship between myosteatosis and bone marrow adiposity. The results showed that postmenopausal women with fragility fractures had higher fat content in the psoas and paravertebral muscles compared to the control group. However, there was no significant association between muscle myosteatosis and bone marrow adiposity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Oncology
Gianpietro Semenzato, Antonella Teramo, Giulia Calabretto, Vanessa Rebecca Gasparini, Renato Zambello
Summary: LGL disorders are rare hematological neoplasias with phenotypic, genotypic, and clinical heterogeneity. STAT signaling plays a crucial role in abnormal cell survival. STAT3 and STAT5b mutations are the most common genetic lesions in T-LGL leukemia and have important implications for diagnosis and classification.
Article
Medical Laboratory Technology
Joshua R. Menke, Michael A. Spinner, Yasodha Natkunam, Roger A. Warnke, Ranjana H. Advani, Dita A. Gratzinger
Summary: NLPHL can present as CD20-negative without prior rituximab therapy, and immunophenotyping is crucial for distinguishing NLPHL from lymphocyte-rich classic Hodgkin lymphoma. CD20-negative NLPHL may exhibit classic and variant histologic patterns and range of clinical behaviors, including potential large cell transformation.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
