Article
Medicine, Research & Experimental
Huan Wang, Zhen Guo, Yu Xu
Summary: MLR is significantly associated with PDR in patients with T2D. Evaluating MLR may have important value for follow-up visits of T2D patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Ophthalmology
Sungsoon Hwang, Se Woong Kang, Sang Jin Kim, Kyu Na Lee, Kyungdo Han, Dong Hui Lim
Summary: This nationwide cohort study aimed to investigate the risk factors for exudative age-related macular degeneration (AMD) in individuals with diabetes. The study analyzed authorized clinical data from the Korean National Health Insurance Service, involving over 1.7 million participants. Data on various factors including duration of diabetes, insulin usage, and presence of vision-threatening diabetic retinopathy were collected, and the association with incident exudative AMD was assessed using a multivariable-adjusted Cox proportional hazard model.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Neurosciences
Zheng Li, Jie Tong, Chang Liu, Mingqiong Zhu, Jia Tan, Guoping Kuang
Summary: The purpose of this study was to investigate the independent risk factors for the development of different degrees of diabetic retinopathy (DR) and non-DR (NDR) in type 2 diabetic patients. The study found that age, fasting blood glucose, and urinary albumin/creatinine ratio were independent risk factors for the progression of DR.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Shengnan Sun, Yahao Wang, Wenru Ma, Bingfei Cheng, Bingzi Dong, Yuhang Zhao, Jianxia Hu, Yue Zhou, Yajing Huang, Fanxiang Wei, Yangang Wang
Summary: This study investigated the association between parathyroid hormone (PTH) levels and non-proliferative diabetic retinopathy (NPDR) in patients with type 2 diabetes mellitus. Results showed that low serum PTH levels were significantly associated with a higher prevalence of NPDR, independent of age, diabetes duration, and other metabolic factors. Further studies are needed to explore the causality.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Xin Wen, Tsz Kin Ng, Qingping Liu, Zhenggen Wu, Guihua Zhang, Mingzhi Zhang
Summary: Diabetic retinopathy (DR) is a microvascular ocular complication of diabetes mellitus (DM) that can cause irreversible blindness and visual impairment. This study aimed to identify the metabolomics signature in tears collected from Chinese type-2 DM patients with DR.
Article
Endocrinology & Metabolism
DanDan Ke, YiYi Hong, XinNan Jiang, XuFang Sun
Summary: This study compared the clinical features and vitreous biomarkers of proliferative diabetic retinopathy (PDR) between patients with early-onset and late-onset type 2 diabetes mellitus (T2DM). The results showed that patients with early-onset T2DM PDR had poor blood glucose and lipid metabolism, higher levels of inflammatory factors, and worse visual prognosis. Age at diabetes diagnosis, hemoglobin A1c (HbA1c), and cytokine levels were independent risk factors for visual acuity after undergoing vitrectomy.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Endocrinology & Metabolism
Xinyuan Zhang, Yao Nie, Zhizhong Gong, Meidong Zhu, Bingjie Qiu, Qiyun Wang
Summary: ApoE, apoC-II/apoC-III, apoE/apoC-II, and apoB/non-HDL-C could be novel biomarkers for the occurrence and severity of DR, while apoA-I and apoA-II are protective factors for DR.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Qian Wang, Ni Zeng, Hongbo Tang, Xiaoxia Yang, Qu Yao, Lin Zhang, Han Zhang, Ying Zhang, Xiaomei Nie, Xin Liao, Feng Jiang
Summary: This study aimed to develop a hazard nomogram for diabetic retinopathy (DR) in Chinese patients with type 2 diabetes mellitus (T2DM). Using data from 213 T2DM patients, the researchers constructed a model that accurately assessed the risk of DR by analyzing eight predictive variables.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Ophthalmology
Karthik Kumar, Girish Baliga, Naresh Babu, Renu P. Rajan, Gautam Kumar, Chitaranjan Mishra, R. Chitra, Kim Ramasamy
Summary: This study compared the clinical profile, visual outcomes, and complications among young adult patients with type 1 and type 2 diabetes mellitus undergoing vitrectomy for complications of PDR. The visual and anatomic outcomes were found to be poorer in type 1 diabetes patients, which may be attributed to longer diabetes duration, poor glycemic control, associated comorbidities like chronic kidney disease, and a higher incidence of MTRD.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Medicine, General & Internal
Ana Maria Dascalu, Anca Pantea Stoian, Alina Popa Cherecheanu, Dragos Serban, Daniel Ovidiu Costea, Mihail Silviu Tudosie, Daniela Stana, Denisa Tanasescu, Alexandru Dan Sabau, Gabriel Andrei Gangura, Andreea Cristina Costea, Vanessa Andrada Nicolae, Catalin Gabriel Smarandache
Summary: Most obese type 2 diabetes patients undergoing bariatric surgery showed stable diabetic retinopathy outcomes postoperatively, with a smaller percentage experiencing new onset or progression. Preoperative preparation and regular ophthalmologic follow-up are essential to minimize the risk of worsening diabetic retinopathy. Further randomized trials are needed to better understand organ-specific risk factors and provide personalized counseling for these patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Yu-Ting Hsiao, Feng-Chih Shen, Shao-Wen Weng, Pei-Wen Wang, Yung-Jen Chen, Jong-Jer Lee
Summary: This study identified genetic determinants of increased risk of diabetic retinopathy (DR) in individuals with type 2 diabetes mellitus (T2DM), focusing on FTO (rs8050136) and PSMD6 (rs831571) genetic variations. By combining genetic and nongenetic risk factors, the predictive model showed improved accuracy in predicting DR risk, especially in patients with poor glycemic control or severe microalbuminuria.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Endocrinology & Metabolism
Di Gong, Lyujie Fang, Yixian Cai, Ieng Chong, Junhong Guo, Zhichao Yan, Xiaoli Shen, Weihua Yang, Jiantao Wang
Summary: This study developed and evaluated a nomogram based on non-imaging clinical data to predict the risk of vision-threatening diabetic retinopathy in type 2 diabetes mellitus patients. The results showed that age, BMI, systolic blood pressure, diabetes duration, and glycated hemoglobin were independent risk factors for diabetic retinopathy in type 2 diabetes mellitus patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Taraprasad Das, Rajagopalaboopathi Jayasudha, SamaKalyana Chakravarthy, Gumpili Sai Prashanthi, Archana Bhargava, Mudit Tyagi, Padmaja Kumari Rani, Rajeev Reddy Pappuru, Savitri Sharma, Sisinthy Shivaji
Summary: The study reveals dysbiosis in the gut microbiome of patients with DR compared to healthy controls, with a decrease in anti-inflammatory and probiotic bacteria. This dysbiosis may impact the treatment of DR and warrants further investigation for developing targeted therapies.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Pedro Romero-Aroca, Raul Navarro-Gil, Gibet Benejam, Montse Vizcarro, Marc Baget-Bernaldiz
Summary: This study compared the differences in multifocal electroretinogram between type 1 diabetes and type 2 diabetes patients. The findings suggest that the retinas of type 1 diabetes patients are more sensitive to changes in HbA1c levels, while the duration of diabetes affects both types of patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Yu-Chien Chung, Ting Xu, Tao-Hsin Tung, Mingchih Chen, Pei-En Chen
Summary: This study aimed to characterize the association between the frequency of screening for diabetic retinopathy (DR) and the detection of DR in patients with newly diagnosed type 2 diabetes mellitus (T2DM). The results showed that periodic screening was more effective than nonperiodic screening in detecting instances of DR in the middle-to-advanced aged group but not among younger patients. The screening pattern did not have a significant effect on the likelihood of DR-related treatment during the 5-year follow-up.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Ophthalmology
Signe Sperling, Lonny Stokholm, Anne Suhr Thykjaer, Frederik Norregaard Pedersen, Soren Moller, Caroline Schmidt Laugesen, Nis Andersen, Jens Andresen, Toke Bek, Morten la Cour, Javad Hajari, Steffen Heegaard, Kurt Hojlund, Ryo Kawasaki, Miriam Kolko, Katja Christina Schielke, Katrine Hass Rubin, Anders Hojslet Vestergaard, Jakob Grauslund
Summary: This study aimed to investigate the prospective association between diabetic retinopathy (DR), glaucoma and/or ocular hypertension (OHT). The results showed that individuals with diabetes were slightly more likely to develop glaucoma and/or OHT, while those with glaucoma and/or OHT were more likely to develop diabetic retinopathy. However, the data does not support including glaucoma evaluation in the national Danish DR-screening program.
ACTA OPHTHALMOLOGICA
(2023)
Article
Ophthalmology
Cris Martin P. Jacoba, Recivall P. P. Salongcay, Lizzie Anne C. Aquino, Claude Michael G. Salva, Aileen V. V. Saunar, Glenn P. P. Alog, Tunde Peto, Paolo S. S. Silva
Summary: The purpose of this study was to compare the performance of handheld retinal imaging and ultrawide field imaging in identifying the severity of diabetic retinopathy (DR). The study found that when using handheld imaging, 37% of patients or 30.8% of eyes with proliferative DR (PDR) were missed. Therefore, lower referral thresholds are needed if handheld devices are used.
ACTA OPHTHALMOLOGICA
(2023)
Article
Ophthalmology
Kathrine Leth-Moller Christensen, Ditte Borup Kristjansen, Anna Stage Vergmann, Thomas Lee Torp, Tunde Peto, Jakob Grauslund
Summary: The purpose of this study was to test if non-invasive measurements of the retinal vascular structure could predict the treatment response in patients with neovascular age-related macular degeneration (nAMD). The results showed that retinal venular length-diameter ratio (LDR) independently predicted the initial treatment response in nAMD patients. If confirmed by long-term prospective studies, this could help guide treatment.
ACTA OPHTHALMOLOGICA
(2023)
Article
Ophthalmology
Nicolas Leveziel, Simon Marillet, Tasanee Braithwaite, Tunde Peto, Pierre Ingrand, Shahina Pardhan, Alain M. Bron, Jost B. Jonas, Serge Resnikoff, Little Julie Anne, Adrian C. Davis, Catherine M. McMahon, Rupert R. A. Bourne
Summary: This study investigated self-reported dual sensory impairment (DSI) in European population and found higher prevalence of DSI in Eastern and southern countries. Social isolation and poor self-rated health status were associated with DSI, while higher income was associated with lower risk. Human Development Index explained almost 38% of the variance of age-adjusted prevalence of DSI.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Recivall P. Salongcay, Cris Martin P. Jacoba, Claude Michael G. Salva, Abdulrahman Rageh, Lizzie Anne C. Aquino, Aileen Saunar, Glenn P. Alog, Mohamed Ashraf, Tunde Peto, Paolo S. Silva
Summary: This study compared the agreement of one-field, two-field, and five-field handheld retinal imaging protocols with the standard seven-field ETDRS photography for the assessment of diabetic retinopathy. The addition of peripheral fields in handheld retinal imaging improved the rate of ungradable images and increased the sensitivity and specificity for referable diabetic retinopathy.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Lizzie Anne C. Aquino, Recivall P. Salongcay, Glenn P. Alog, Kaye B. Locaylocay, Aileen Saunar, Tunde Peto, Paolo S. Silva
Summary: This study compared the efficacy of 2-field and 5-field mydriatic handheld retinal imaging for assessing the severity of diabetic retinopathy (DR), and found that there was substantial agreement between the two methods. However, the 2-field imaging had lower sensitivity and specificity for vision-threatening DR compared to the 5-field imaging, and had a higher rate of ungradable images.
Review
Ophthalmology
Jakob Bjerager, Miklos Schneider, Ivan Potapenko, Elon H. C. van Dijk, Carsten Faber, Jakob Grauslund, Kristina Pfau, Josef Huemer, Danson V. Muttuvelu, Marie L. R. Rasmussen, M. Cem Sabaner, Yousif Subhi
Summary: Patients with nonneovascular AMD are encouraged to use the Amsler grid test for self-assessment, but its sensitivity is not recommended for monitoring. Ophthalmic examination should be regularly conducted regardless of the results of Amsler grid self-assessment.
JAMA OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Sophie J. Bakri, Marie-Noelle Delyfer, Jakob Grauslund, Steffen Andersen, Helene Karcher
Summary: A study found that there is an association between treatment interval and discontinuation rate in patients with diabetic macular edema (DME) receiving anti-VEGF injections. Patients with longer treatment intervals at 24 months had consistently higher discontinuation rates in the following years than those with shorter intervals, which is clinically significant.
OPHTHALMOLOGY AND THERAPY
(2023)
Letter
Medicine, General & Internal
Benjamin Sommer Thinggaard, Frederik Pedersen, Jakob Grauslund, Lonny Stokholm
Summary: This cohort study examines the use and forecast of intravitreal injections of vascular endothelial growth factor inhibitor in Denmark from 2007 through 2022.
Article
Health Care Sciences & Services
Tobias P. H. Nissen, Thomas L. Norgaard, Katja C. Schielke, Peter Vestergaard, Amar Nikontovic, Malgorzata Dawidowicz, Jakob Grauslund, Henrik Vorum, Kristian Aasbjerg
Summary: The purpose of this study was to examine the performance of RetinaLyze, a support vector machine learning software, in identifying diabetic retinopathy in patients with diabetes. The results showed that the software performed well compared to human grading. Further clinical testing is recommended before implementing the software as a decision support tool.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Ophthalmology
Lasse Jorgensen Cehofski, Kentaro Kojima, Natsuki Kusada, Maja Rasmussen, Danson Vasanthan Muttuvelu, Jakob Grauslund, Henrik Vorum, Bent Honore
Summary: Proteomic analysis of aqueous humor in patients with central retinal vein occlusion (CRVO) revealed differential expression of various proteins that correlated with visual acuity and macular edema severity, including fibrinogen, fibronectin, and immunoglobulins.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Endocrinology & Metabolism
Anne S. S. Thykjaer, Louise Rosengaard, Nis Andersen, Jens Andresen, Toke Bek, Javad Hajari, Steffen Heegaard, Kurt Hojlund, Ryo Kawasaki, Caroline S. S. Laugesen, Soren Moller, Frederik N. N. Pedersen, Katja C. C. Schielke, Lonny Stokholm, Jakob Grauslund
Summary: This study evaluated the risk of short and long-term diabetic retinopathy (DR) development and need for ocular intervention in individuals with type 2 diabetes (T2D) undergoing bariatric surgery. The results showed that bariatric surgery did not associate with increased risk of DR worsening.
ACTA DIABETOLOGICA
(2023)
Article
Endocrinology & Metabolism
Cristina Hernandez, Olga Simo-Servat, Massimo Porta, Jakob P. Grauslund, Simon Harding, Ulrik Frydkjaer-Olsen, Jose Garcia-Arumi, Luisa Ribeiro, Peter Scanlon, Jose Cunha-Vaz, Rafael Simo
Summary: This study aimed to assess the usefulness of serum biomarkers GFAP and NfL in identifying and monitoring retinal neurodysfunction in type 2 diabetes patients. The levels of GFAP and NfL in the serum were directly correlated with age and with each other. Additionally, higher baseline levels of GFAP were found in patients who showed progression of neurodysfunction after 2 years of follow-up.
ACTA DIABETOLOGICA
(2023)
Article
Health Care Sciences & Services
Lasse Jorgensen Cehofski, Anders Kruse, Mads Odgaard Maeng, Benedict Kjaergaard, Jakob Grauslund, Bent Honore, Henrik Vorum
Summary: Bevacizumab intervention results in altered levels of retinal proteins, including components of bevacizumab itself. The changes suggest a narrow mechanism of action.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Letter
Ophthalmology
Jakob Grauslund, Lonny Stokholm, Nis Andersen, Jens Andresen, Toke Bek, Soren Tang Knudsen, Yousif Subhi
ACTA OPHTHALMOLOGICA
(2023)