Review
Biology
Masataka Taniuchi, Tetsuya Terada, Ryo Kawata
Summary: Fine-needle aspiration cytology is widely used for preoperative evaluation of parotid tumors, with core needle biopsy and liquid-based cytology improving reliability of immunostaining and molecular testing.
Review
Pathology
Richard L. Cantley
Summary: Fine needle aspiration cytology plays an important role in distinguishing primary and metastatic adrenal neoplasms, but there is variability. Immunohistochemistry can aid in the diagnosis of adrenal neoplasms.
ADVANCES IN ANATOMIC PATHOLOGY
(2022)
Article
Multidisciplinary Sciences
Noor Ulain, Asif Ali, Momin Khan, Zakir Ullah, Lubna Shaheen, Naveed Shareef, Muhammad Yasir, Tehmina Mustafa
Summary: Immunohistochemistry detection of MPT64 antigen is a reliable and rapid method for diagnosing tuberculous lymphadenitis, with better performance compared to ZN staining and cytomorphology.
Article
Gastroenterology & Hepatology
Silvia Carrara, Daoud Rahal, Kareem Khalaf, Tommy Rizkala, Glenn Koleth, Cristiana Bonifacio, Marta Andreozzi, Benedetto Mangiavillano, Francesco Auriemma, Paola Bossi, Monica Balzarotti, Antonio Facciorusso, Teresa Staiano, Elena Maldi, Marco Spadaccini, Matteo Colombo, Alessandro Fugazza, Roberta Maselli, Cesare Hassan, Alessandro Repici
Summary: This study aimed to evaluate the diagnostic accuracy and adverse event rate of EUS-guided fine-needle biopsy sampling (EUS-FNB) in diagnosing lymphadenopathies (LAs). The results showed that EUS-FNB with new end-cutting needles is a valuable and safe method for diagnosing LAs.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Dermatology
E. E. Siddig, O. El Had Bakhait, M. El Nour Hussein Bahar, E. Siddig Ahmed, S. M. Bakhiet, M. Motasim Ali, O. Babekir Abdallah, R. Ahmed Hassan, A. Verbon, W. W. J. van de Sande, A. H. Fahal
Summary: Ultrasound-guided fine-needle aspiration cytology (US-FNAC) has higher diagnostic accuracy than conventional FNAC for the diagnosis of mycetoma, allowing for rapid differentiation between the two types of mycetoma.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Oncology
Shifa Yuan, Zhijun Liu, Shanshan Yu, Xiaolei Wang, Jian Shi
Summary: This study investigated the relationship between cyclin D2 (CCND2) and miR-206 expression in fine-needle aspiration cytology of thyroid carcinoma. The results showed that the expression level of miR-206 was significantly decreased and CCND2 was significantly increased in thyroid cancer patients compared to those with benign thyroid nodules. CCND2 and miR-206 expression were negatively correlated in thyroid cancer tissues. They may become new biomarkers for clinical diagnosis of thyroid cancer based on fine-needle aspiration cytology of thyroid nodules.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Isabela Panzeri Carlotti Buzatto, Francisco Jose Candido dos Reis, Jurandyr Moreira de Andrade, Tamara Cristina Gomes Ferraz Rodrigues, Jessica Maria Camargo Borba, Amanda Homse Netto, Marina Sconzo Polydoro, Daniel Guimaraes Tiezzi
Summary: The study demonstrated that axillary ultrasound coupled with fine-needle aspiration cytology is effective in evaluating axillary involvement in breast cancer patients. Ultrasound combined with FNAC showed high specificity in accurately predicting clinically relevant node metastasis in patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jeeyong Lee, Hwa Jeong Ha, Da Yeon Kim, Jae Soo Koh, Eun Ju Kim
Summary: Fine needle aspiration cytology (FNAC) is a valuable tool for evaluating lymphadenopathy and diagnosing malignant tumors. However, some tumor diagnoses may still be unclear. In this study, we used mRNA sequencing technology to re-analyze misinterpreted patient samples and identified under-diagnosed characteristics of non-Hodgkin's lymphoma. Through bioinformatic and biological analysis, we identified genes and pathways potentially involved in this type of tumor. FOS, ENDOG, and PRKAR2B were identified as hub genes, and their association with lymphoma was confirmed by the cBioPortal database. These findings suggest the potential use of these candidate genes as biomarkers to improve the accuracy of FNAC diagnosis in lymphadenopathy, ultimately leading to better prognosis for patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Xiaohua Wang, Xiang Shi, Dahua Sun, Meiping Wan
Summary: This case report analyzed the clinical symptoms, fine-needle aspiration cytology, histopathological and immunohistochemical results of a patient with angiolymphoid hyperplasia with eosinophilia (ALHE), and summarized the clinicopathological diagnostic features of the disease. As far as we know, this is the first comprehensive report on the cytological, histopathological and immunophenotypic characteristics of ALHE, which could contribute to a better understanding of this rare proliferative tumor for clinicians.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Medicine, General & Internal
Hwa Jeong Ha, Jeeyong Lee, Da Yeon Kim, Jung-Soon Kim, Myung-Soon Shin, Insup Noh, Jae Soo Koh, Eun Ju Kim, Seung-Sook Lee
Summary: This study assessed the reliability and effectiveness of fine needle aspiration cytology (FNAC) in the diagnosis of lymphadenopathy. The results showed that FNAC was safe, practical, and effective in the early diagnosis of lymphadenopathy. However, it had limitations in some diagnoses, suggesting the need for additional attempts according to the clinical situation.
Article
Computer Science, Artificial Intelligence
Nguyen Thanh Duc, Yong-Moon Lee, Jae Hyun Park, Boreom Lee
Summary: The study utilized artificial intelligence for automated classification of Papillary Thyroid Carcinoma cell clusters, achieving high accuracy and reliability through segmentation of cytological images and deep learning model pre-training and fine-tuning.
EXPERT SYSTEMS WITH APPLICATIONS
(2022)
Article
Health Care Sciences & Services
Carolla El Chamieh, Philippe Vielh, Sylvie Chevret
Summary: Statistical issues in evaluating the diagnostic accuracy of fine needle aspiration cytology for breast cancer, such as suspect test results and verification bias, were addressed using various methods including conditional estimates, Begg and Greenes method, multivariate imputation by chained equations, and a Bayesian approach. The FNAC test demonstrated high specificity, always above 94%, and performed better as a rule-in test for breast cancer diagnosis.
BMC MEDICAL RESEARCH METHODOLOGY
(2022)
Review
Medicine, General & Internal
Georgios D. Koimtzis, Christopher G. Chalklin, Eliot Carrington-Windo, Mark Ramsden, Leandros Stefanopoulos, Christoforos S. Kosmidis
Summary: Gallbladder cancer is the most common malignancy of the biliary tract, and early diagnosis and assessment are crucial for improving survival rates. Fine needle aspiration cytology has high sensitivity and specificity in the management of gallbladder cancer, suggesting that suspicious masses should be further evaluated with FNAC for appropriate management.
Article
Oncology
Tanner Freeman, Charit Taneja, N. Paul Ohori, Abigail Wald, John Skaugen, Linwah Yip, Seungwon Kim, Robert L. Ferris, Marina N. Nikiforova, Somak Roy, Yuri E. Nikiforov
Summary: This study demonstrates that molecular testing can reliably identify metastatic RCC in thyroid nodules with indeterminate cytology, which could improve patient management.
ENDOCRINE-RELATED CANCER
(2022)
Article
Pathology
Kaveri Hallikeri, Biji Babu, Archana Sudhakaran, Roshni Monteiro
Summary: The study compared the role and efficacy of fine needle aspiration cytology (FNAC) and cell block in diagnosing jaw lesions. Cell block technique preserved the architectural pattern and morphology of cells better, making it a useful ancillary technique for definitive diagnosis of head and neck swellings.