Journal
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS
Volume 68, Issue -, Pages 978-980Publisher
INT UNION CRYSTALLOGRAPHY
DOI: 10.1107/S1744309112028989
Keywords
glyceraldehyde-3-phosphate dehydrogenases; Saccharomyces cerevisiae
Funding
- Fundamental Research Funds for the Central Universities
- Chinese National Natural Science Foundation [31130018, 30900224, 10979039]
- Chinese Ministry of Science and Technology [2012CB917200, 2009CB825500]
- Science and Technological Fund of Anhui Province for Outstanding Youth [10040606Y11]
- Anhui Provincial Natural Science Foundation [090413081]
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Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an important enzyme in the glycolytic pathway. In addition to its conventional metabolic role, GAPDH has been identified to possess diverse cellular functions. In this study, glyceraldehyde-3-phosphate dehydrogenase 3, the third isoform of GAPDH from Saccharomyces cerevisiae, was cloned, expressed, purified and crystallized. The crystals belonged to space group I4122, with unit-cell parameters a = b = 116.13, c = 119.21 angstrom. X-ray diffraction data were collected to a resolution of 2.6 angstrom. The structure was solved by molecular replacement and refinement is in progress.
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