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Crystallization of community-acquired respiratory distress syndrome toxin from Mycoplasma pneumoniae

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INT UNION CRYSTALLOGRAPHY
DOI: 10.1107/S1744309110000114

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Funding

  1. Robert A. Welch Foundation [AQ-1399]
  2. IH [U19 AI070412]
  3. Kleberg Foundation

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Community-acquired respiratory distress syndrome toxin (CARDS TX) is a 591-amino-acid protein with ADP-ribosyltransferase and vacuolating activities that damages the cells lining the respiratory tracts of patients infected with the bacterial pathogen Mycoplasma pneumoniae. Crystals of CARDS TX were grown in space group C2, with unit-cell parameters a = 191.4, b = 107.4, c = 222.1 angstrom, beta = 90.6 degrees. A complete 2.2 angstrom data set was obtained from a single CARDS TX crystal.

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