Article
Biotechnology & Applied Microbiology
Robert Kammerer, Wolfgang Zimmermann
Summary: This study found that Psg genes are only present in the suborder Myomorpha of rodents, and these genes are located in a specific region of the genome and are highly expressed by trophoblast cells. In contrast, Psg genes were not found in other suborders. This suggests that Psg genes have evolved recently in rodents.
Article
Public, Environmental & Occupational Health
Farshad Teymoori, Ebrahim Mokhtari, Mitra Kazemi Jahromi, Hossein Farhadnejad, Parvin Mirmiran, Mohammadreza Vafa, Fereidoun Azizi
Summary: This study aimed to investigate the association of the Empirical Dietary Index for Hyperinsulinemia (EDIH) and Empirical Lifestyle Index for Hyperinsulinemia (ELIH) with the risk of obesity phenotypes among Iranian adults. The findings revealed that higher ELIH scores were associated with greater risks for MUO and MHO incidence, while higher EDIH scores were related to an increased risk of MUO but not MHO. This suggests that a high insulinemic potential of diet and lifestyle may lead to an increase in the simultaneous occurrence of obesity with metabolic disorders in Iranian adults.
Article
Critical Care Medicine
Runzhi Huang, Tong Meng, Qiongfang Zha, Kebin Cheng, Xin Zhou, Junhua Zheng, Dingyu Zhang, Ruilin Liu
Summary: This study identified CEA as the only laboratory indicator significantly associated with prognosis in COVID-19 patients. Analysis of single-cell transcriptome data revealed the potential role of CEA in lungs and peripherals in the progression of COVID-19.
Article
Cell Biology
Harrison T. Muturi, Saja S. Khuder, Hilda E. Ghadieh, Emily L. Esakov, Hyelim Noh, Heejoon Kang, Marcia F. McInerney, Jason K. Kim, Abraham D. Lee, Sonia M. Najjar
Summary: CEACAM1 plays a significant role in maintaining endothelial barrier integrity and insulin sensitivity in peripheral tissues. Loss of endothelial Ceacam1 affects lipid metabolism but does not impair insulin sensitivity.
Article
Biochemistry & Molecular Biology
Fabiano Cimmino, Angela Catapano, Giovanna Trinchese, Gina Cavaliere, Rosanna Culurciello, Chiara Fogliano, Eduardo Penna, Valeria Lucci, Marianna Crispino, Bice Avallone, Elio Pizzo, Maria Pina Mollica
Summary: Obesity and metabolic disturbances are increasing globally due to unhealthy diets and lack of physical activity, leading to non-communicable diseases. Nutritional components can modulate metabolic homeostasis, with DMG-gold showing promise in preventing or delaying NCD onset.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Aditya Gupta, Andrew J. Rosato, Feng Cui
Summary: CEACAM molecules are a family of membrane glycoproteins that mediate intercellular interactions and have potential as targets for cancer immunotherapy. A multi-epitope vaccine candidate targeting a conserved domain has been developed using immunoinformatics tools, showing high antigenicity and low allergenicity.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Oncology
Fatemeh Sheikhhossein, Sakineh Shab-Bidar, Mohammad Reza Amini, Fatemeh Hosseini, Hossein Imani
Summary: The study found no association between dietary insulin index and load with the risk of breast cancer.
CLINICAL BREAST CANCER
(2021)
Article
Biotechnology & Applied Microbiology
Wolfgang Zimmermann, Robert Kammerer
Summary: This study analyzed PSG genes in 57 primate species with hemochorial or epitheliochorial placentation. The results showed that almost all analyzed apes had around 10 PSG genes each, while Old World monkey genomes had 6 to 24 PSG genes. Surprisingly, only 1 to 7 PSG genes were identified in New World monkeys. The distribution and selection pattern of PSG in primates support the hypothesis that PSG are still evolving to optimize interactions between fetus and mother or potential pathogens in mammals with hemochorial placentation.
Article
Oncology
A. Gazzah, P. L. Bedard, C. Hierro, Y-K Kang, A. Abdul Razak, M-H Ryu, B. Demers, N. Fagniez, C. Henry, M. Hospitel, J-C Soria, J. Tabernero
Summary: This study evaluated the safety, pharmacokinetics, and preliminary antitumor activity of tusamitamab ravtansine in patients with solid tumors. Tusamitamab ravtansine demonstrated a favorable safety profile with reversible, dose-related keratopathy as the dose-limiting toxicity. The maximum tolerated dose of tusamitamab ravtansine was determined to be 100 mg/m(2) every 2 weeks based on overall safety profile, pharmacokinetic data, and Bayesian model recommendations.
ANNALS OF ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Christopher Mendoza, Dario Mizrachi
Summary: Decades of evidence suggest that alterations in cell adhesion properties contribute to the invasive and migratory phenotype of neoplastic cells. The role of tight junction proteins in the tumor microenvironment is crucial. Reprogramming immune cells using CAR-T cells to target and eliminate tumors has been approved as a therapy. Researchers have developed a new biologic that specifically targets cancer cells and reduces proliferation and metastasis.
Article
Biochemistry & Molecular Biology
Ana Paula Varela Sanches, Josilene Lopes de Oliveira, Maira Schuchter Ferreira, Bruna de Souza Lima, Josiane Erica Miyamoto, Lais Angelica de Paula Simino, Marcio Alberto Torsoni, Adriana Souza Torsoni, Marciane Milanski, Leticia Ignacio-Souza
Summary: The aim of this study was to investigate the parameters of maternal-fetal outcomes in a diet-induced obesity model. Females who were obese and glucose intolerant prior to pregnancy had lower placental efficiency and lower birth weight pups compared to the controls. The study found that maternal obesity disrupts the proportionality between maternal and fetal outcomes during pregnancy, which could be due to hormonal signaling issues and inflammation in the maternal metabolic environment. Maternal obesity also alters placental thickness, fatty acid transport, and the expression of growth factors. Lower expression of epidermal growth factor receptor (EGFR) mRNA in obese mothers may have contributed to placental rupture and adverse fetal outcomes. Maintaining maternal glucose homeostasis and overexpression of placental growth factor (PGF) likely protected the placenta and fetuses from damage.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Oncology
Seung-Myoung Son, Jieun Yun, Dong-Wook Kim, Young-Suk Jung, Sang-Bae Han, Yong Hee Lee, Hye Sook Han, Chang Gok Woo, Ho-Chang Lee, Ok-Jun Lee
Summary: Delivery of miR-29a to lung adenocarcinoma cells using a peptide vector in the acidic tumor microenvironment has therapeutic potential as a unique cancer treatment approach.
Article
Virology
Shah Kamranur Rahman, Mairaj Ahmed Ansari, Pratibha Gaur, Imtiyaz Ahmad, Chandrani Chakravarty, Dileep Kumar Verma, Anshika Sharma, Sanjay Chhibber, Naila Nehal, Dagmar Wirth, Sunil K. Lal
Summary: The study identified CD66c as a specific glycoprotein receptor for Influenza A virus, playing a key role in virus entry into human epithelial lung cells and affecting virus binding and entry significantly.
Article
Biotechnology & Applied Microbiology
Zhao-Peng Kang, Li-Xin Wang, Jun Liu, Hai Ouyang, Sheng Xie, Yan Tan
Summary: Down-regulation of CEACAM1 in RCC may promote angiogenesis, while up-regulation of CD105 may promote RCC progression. Microvessel density (MVD) could be an indicator of RCC malignancy.
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION
(2021)
Article
Agriculture, Dairy & Animal Science
Wellison J. S. Diniz, Alison K. Ward, Kacie L. McCarthy, Cierrah J. Kassetas, Friederike Baumgaertner, Lawrence P. Reynolds, Pawel P. Borowicz, Kevin K. Sedivec, James D. Kirsch, Sheri T. Dorsam, Tammi L. Neville, J. Chris Forcherio, Ronald Scott, Joel S. Caton, Carl R. Dahlen
Summary: Maternal nutrient supply during the periconceptual period has long-term effects on fetal development and tissue function. Our study investigated the impacts of maternal vitamin and mineral supplementation and rate of body-weight gain during early pregnancy on fetal liver development and gene expression profiles. We found that maternal nutrition during the periconceptual period affects fetal hepatic function through altered expression of energy- and lipid-related genes.
Article
Endocrinology & Metabolism
Andrew C. Shin, Priya Balasubramanian, Pavan Suryadevara, Justin Zyskowski, Thomas H. Herdt, Sheba M. J. MohanKumar, Puliyur S. MohanKumar
Summary: This study demonstrated that oral metformin can effectively reduce weight gain, fat mass, and caloric intake in obesity-prone rats. Metformin dose-dependently decreased HPA axis activity, normalized NE-HPA axis coupling, and reduced circulating free fatty acids levels in these rats. These findings reveal a novel effect of metformin in correcting HPA axis dysfunction associated with obesity.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Environmental Sciences
Josephine Bou Dagher, Coral K. Hahn-Townsend, Amrita Kaimal, Maryam Al Mansi, Joseph E. Henriquez, Diane G. Tran, Christian R. Laurent, Caleb J. Bacak, Hannah E. Buechter, Celexis Cambric, Jared Spivey, Yen-Jun Chuang, Elyssa J. Campbell, Abhyuday Mandal, Puliyur S. Mohankumar, Sheba M. J. MohanKumar
Summary: The study found that a mixture of BPA and DEHP significantly affected pregnancy outcomes, with male offspring appearing more susceptible to the programming effects of these chemicals or their mixture. The results emphasize the need to reconsider the possible additive, antagonistic, or synergistic effects of EDC mixtures.
Article
Environmental Sciences
Amrita Kaimal, Maryam H. Al Mansi, Josephine Bou Dagher, Catherine Pope, Marissa G. Varghese, Thomas B. Rudi, Ansley E. Almond, Loren A. Cagle, Hermela K. Beyene, William T. Bradford, Benjamin B. Whisnant, Baobsom D. K. Bougouma, Karim J. Rifai, Yen-Jun Chuang, Elyssa J. Campbell, Abhyuday Mandal, Puliyur S. MohanKumar, Sheba M. J. MohanKumar
Summary: The study evaluated the effects of gestational exposure to low doses of BPA, BPS, and BPF on pregnancy outcomes and offspring development. Results showed that prenatal exposure to BPF led to spontaneous abortions, while BPS exposure reduced anogenital distance in male offspring. All three bisphenols altered certain organ weights in male offspring and ovarian function in female offspring.
Article
Biochemistry & Molecular Biology
Kimberly A. Clark, Andrew C. Shin, Madhu P. Sirivelu, Ramya C. MohanKumar, Sreenivasa R. Maddineni, Ramesh Ramachandran, Puliyur S. MohanKumar, Sheba M. J. MohanKumar
Summary: The study showed that leptin gene therapy in STZ-induced diabetic rats was able to partially normalize some neuroendocrine abnormalities, but higher doses of the leptin lentiviral vector (Lepvv) are needed to develop this into a viable option for treating T1D.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ashraf Nahle, Yemisi Deborah Joseph, Sandra Pereira, Yusaku Mori, Frankie Poon, Hilda E. Ghadieh, Aleksandar Ivovic, Tejas Desai, Simona S. Ghanem, Suman Asalla, Harrison T. Muturi, Emelien M. Jentz, Jamie W. Joseph, Sonia M. Najjar, Adria Giacca
Summary: The study showed that NMN can improve glucose tolerance caused by a high-fat diet, but it may impair glucose tolerance under normal levels of free fatty acids. Therefore, caution should be exercised when considering the therapeutic use of NMN due to its dual effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Magda Shaheen, Katrina M. Schrode, Deyu Pan, Dulcie Kermah, Vishwajeet Puri, Ali Zarrinpar, David Elisha, Sonia M. Najjar, Theodore C. Friedman
Summary: The study found that Mexican American males in the US population have a higher risk of NAFLD compared to other ethnic groups and females, particularly in moderate and severe cases. Interventions targeting Mexican American males are needed to increase awareness about NAFLD and its prevention.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Raghd Abu Helal, Harrison T. Muturi, Abraham D. Lee, Wei Li, Hilda E. Ghadieh, Sonia M. Najjar
Summary: Mice with endothelial cell-specific Ceacam1 deletion on C57BL/6J.Ldlr(-/-) background exhibited insulin sensitivity despite hypercholesterolemia and showed increased inflammation and fibrosis without significant fat deposition on aortic walls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Sonia M. Najjar, Raziyeh Abdolahipour, Hilda E. Ghadieh, Marziyeh Salehi Jahromi, John A. Najjar, Basil A. M. Abuamreh, Sobia Zaidi, Sivarajan Kumarasamy, Harrison T. Muturi
Summary: Insulin stores lipid in adipocytes and prevents lipolysis and the release of NEFA. Excessive release of NEFA and increased abdominal adiposity trigger insulin resistance, leading to reduced insulin clearance in the liver. Conversely, reduced insulin clearance in the liver can cause chronic hyperinsulinemia and insulin resistance. This review discusses the impact of NEFA mobilization on the reciprocal relationship between insulin resistance and reduced hepatic insulin clearance, and its implications in the pathogenesis of non-alcoholic fatty liver disease.
Review
Physiology
Sonia M. Najjar, Sonia Caprio, Amalia Gastaldelli
Summary: Insulin action is impaired in type 2 diabetes due to genetic or acquired abnormalities of insulin secretion or action. Reduction of insulin clearance, particularly through the membrane glycoprotein CEACAM1, has been suggested to contribute to the disease process. This review explores the evidence linking reduced insulin clearance to insulin resistance, obesity, hepatic steatosis, and type 2 diabetes.
ANNUAL REVIEW OF PHYSIOLOGY
(2023)
Article
Cell Biology
Md Abu Bakkar Siddik, Caitlyn A. Mullins, Alyssa Kramer, Harsh Shah, Ritchel B. Gannaban, Masoud Zabet-Moghaddam, Ryan M. Huebinger, Vijay K. Hegde, Sheba M. J. MohanKumar, Puliyur S. MohanKumar, Andrew C. Shin
Summary: This study reveals a positive association between circulating BCAAs and AD. BCAAs may impair neuronal functions, while BCAA-lowering can alleviate AD-related pathology and cognitive decline, establishing a potential causal link between BCAAs and AD progression.
Editorial Material
Biochemistry & Molecular Biology
Hilda E. Ghadieh, Amalia Gastaldelli, Sonia M. Najjar
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Magda Shaheen, Katrina M. Schrode, Marielle Tedlos, Deyu Pan, Sonia M. Najjar, Theodore C. Friedman
Summary: This study investigated the prevalence and association between race, gender, and NAFLD in prediabetes and diabetes populations among adults in the United States. The results showed that prediabetes and diabetes populations had a higher prevalence and odds of NAFLD compared to the normoglycemic population, and elevated HbA1c levels were associated with greater NAFLD severity. Therefore, healthcare providers should screen prediabetes and diabetes populations for early detection of NAFLD and initiate appropriate treatments.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
Bijinu Balakrishnan, Abhishek Gupta, Rabia Basri, Vishva M. Sharma, Mark Slayton, Kailey Gentner, Chloe C. Becker, Shakun Karki, Harrison Muturi, Sonia M. Najjar, Analia S. Loria, Noyan Gokce, Vishwajeet Puri
Summary: CIDEC, a protein associated with lipid droplets in adipocytes, is abundantly expressed in human endothelial cells and regulates vascular function. In a mouse model expressing endothelial-specific human CIDEC, protection against high-fat diet-induced glucose intolerance, insulin resistance, and dyslipidemia was observed. This protection was attributed to the modulation of VEGF signaling pathway by CIDEC. These findings suggest CIDEC as a potential therapeutic target for obesity-related cardiometabolic diseases.
Meeting Abstract
Cardiac & Cardiovascular Systems
Bijinu Balakrishnan, Abhishek Gupta, Vishva M. Sharma, Mark Slayton, Kailey Gentner, Shakun Karki, Harrison Muturi, Sonia M. Najjar, Analia S. Loria, Noyan Gokce, Vishwajeet Puri
CIRCULATION RESEARCH
(2022)
Meeting Abstract
Hematology
Bijinu Balakrishnan, Abhishek Gupta, Vishva Sharma, Mark Slayton, Kailey Gentner, Shakun Karki, Harrison Muturi, Sonia M. Najjar, Analia Loria, Noyan Gokce, Vishwajeet Puri
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)