Journal
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS
Volume 64, Issue -, Pages 584-588Publisher
INT UNION CRYSTALLOGRAPHY
DOI: 10.1107/S1744309108016035
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Funding
- NCRR NIH HHS [RR-15301, P41 RR015301] Funding Source: Medline
- NIGMS NIH HHS [R01 GM074027, GM074027] Funding Source: Medline
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The Escherichia coli AcrR multidrug-binding protein represses transcription of acrAB and is induced by many structurally unrelated cytotoxic compounds. The crystal structure of AcrR in space group P222(1) has been reported previously. This P2221 structure has provided direct information about the multidrug-binding site and important residues for drug recognition. Here, a crystal structure of this regulator in space group P3(1) is presented. Comparison of the two AcrR structures reveals possible mechanisms of ligand binding and AcrR regulation.
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