Microenvironment in metastasis: roadblocks and supportive niches

The Osteogenic Niche Promotes Early-Stage Bone Colonization of Disseminated Breast Cancer Cells

(2015) Hai Wang et al.   CANCER CELL

The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?

(2015) Vicki Plaks et al.   Cell Stem Cell

The relevance of EMT in breast cancer metastasis: Correlation or causality?

(2015) Ruben Bill et al.   FEBS LETTERS

The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase

(2015) Thomas R. Cox et al.   NATURE

Reactive Astrocytes Protect Melanoma Cells from Chemotherapy by Sequestering Intracellular Calcium through Gap Junction Communication Channels

(2015) Qingtang Lin et al.   NEOPLASIA

GAS6/AXL Axis Regulates Prostate Cancer Invasion, Proliferation, and Survival in the Bone Marrow Niche

(2015) Yusuke Shiozawa et al.   NEOPLASIA

Astrocytes Upregulate Survival Genes in Tumor Cells and Induce Protection from Chemotherapy

(2015) Sun-Jin Kim et al.   NEOPLASIA

Breast Fibroblasts Modulate Early Dissemination, Tumorigenesis, and Metastasis through Alteration of Extracellular Matrix Characteristics

(2015) Nancy Dumont et al.   NEOPLASIA

Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial–mesenchymal transition in hepatocellular carcinoma

(2014) Qing-Min Fan et al.   CANCER LETTERS

Myeloid WNT7b Mediates the Angiogenic Switch and Metastasis in Breast Cancer

(2014) E.-J. Yeo et al.   CANCER RESEARCH

Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis

(2014) Manuel Valiente et al.   CELL

Metastatic Stem Cells: Sources, Niches, and Vital Pathways

(2014) Thordur Oskarsson et al.   Cell Stem Cell

A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages

(2014) Haihui Lu et al.   NATURE CELL BIOLOGY

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reactive Gliosis and the Multicellular Response to CNS Damage and Disease

(2014) Joshua E. Burda et al.   NEURON

Inhibition of tumor cell proliferation and motility by fibroblasts is both contact and soluble factor dependent

(2014) Twana Alkasalias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells

(2014) M. Ono et al.   Science Signaling

Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts

(2014) Suling Liu et al.   Stem Cell Reports

Extracellular matrix components in breast cancer progression and metastasis

(2013) Thordur Oskarsson   BREAST

Origins of Metastatic Traits

(2013) Sakari Vanharanta et al.   CANCER CELL

Endothelial Cells Promote the Colorectal Cancer Stem Cell Phenotype through a Soluble Form of Jagged-1

(2013) Jia Lu et al.   CANCER CELL

Selection of Bone Metastasis Seeds by Mesenchymal Signals in the Primary Tumor Stroma

(2013) Xiang H.-F. Zhang et al.   CELL

Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain

(2013) Fei Xing et al.   EMBO Molecular Medicine

Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay

(2013) Irène Baccelli et al.   NATURE BIOTECHNOLOGY

TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling

(2013) Paloma Bragado et al.   NATURE CELL BIOLOGY

The perivascular niche regulates breast tumour dormancy

(2013) Cyrus M. Ghajar et al.   NATURE CELL BIOLOGY

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

(2013) M. Yu et al.   SCIENCE

Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors

(2012) Anne-Katrine Bonde et al.   BMC CANCER

The metastatic niche and stromal progression

(2012) Jonathan P. Sleeman   CANCER AND METASTASIS REVIEWS

Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation

(2012) Alexandre Calon et al.   CANCER CELL

Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1

(2012) Oscar H. Ocaña et al.   CANCER CELL

Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis

(2012) Jeff H. Tsai et al.   CANCER CELL

Myeloid Progenitor Cells in the Premetastatic Lung Promote Metastases by Inducing Mesenchymal to Epithelial Transition

(2012) D. Gao et al.   CANCER RESEARCH

Convergent Multi-miRNA Targeting of ApoE Drives LRP1/LRP8-Dependent Melanoma Metastasis and Angiogenesis

(2012) Nora Pencheva et al.   CELL

The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites

(2012) Hua Gao et al.   CELL

A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis

(2012) Swarnali Acharyya et al.   CELL

Cancer-Associated Fibroblasts Drive the Progression of Metastasis through both Paracrine and Mechanical Pressure on Cancer Tissue

(2012) G. S. Karagiannis et al.   MOLECULAR CANCER RESEARCH

Classifying collective cancer cell invasion

(2012) Peter Friedl et al.   NATURE CELL BIOLOGY

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Dormancy Signatures and Metastasis in Estrogen Receptor Positive and Negative Breast Cancer

(2012) Ryung S. Kim et al.   PLoS One

Circulating Tumor Cells as a Window on Metastasis Biology in Lung Cancer

(2011) Jian-Mei Hou et al.   AMERICAN JOURNAL OF PATHOLOGY

Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch Signaling

(2011) Masahiro Sonoshita et al.   CANCER CELL

VCAM-1 Promotes Osteolytic Expansion of Indolent Bone Micrometastasis of Breast Cancer by Engaging α4β1-Positive Osteoclast Progenitors

(2011) Xin Lu et al.   CANCER CELL

Macrophage Binding to Receptor VCAM-1 Transmits Survival Signals in Breast Cancer Cells that Invade the Lungs

(2011) Qing Chen et al.   CANCER CELL

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells

(2011) Nilay Sethi et al.   CANCER CELL

Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis

(2011) Myriam Labelle et al.   CANCER CELL

Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth

(2011) Michael Quante et al.   CANCER CELL

Gap Junction-Mediated Import of MicroRNA from Bone Marrow Stromal Cells Can Elicit Cell Cycle Quiescence in Breast Cancer Cells

(2011) P. K. Lim et al.   CANCER RESEARCH

Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells

(2011) Piyush B. Gupta et al.   CELL

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast

(2011) Christina Scheel et al.   CELL

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse

(2011) Anna Merlos-Suárez et al.   Cell Stem Cell

Extracellular matrix players in metastatic niches

(2011) Thordur Oskarsson et al.   EMBO JOURNAL

Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow

(2011) Yusuke Shiozawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone

(2011) Aya Kobayashi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of stromal cell-derived factor-1α further impairs diabetic wound healing

(2011) Dustin M. Bermudez et al.   JOURNAL OF VASCULAR SURGERY

Mechanism of the Mesenchymal-Epithelial Transition and Its Relationship with Metastatic Tumor Formation

(2011) D. Yao et al.   MOLECULAR CANCER RESEARCH

Role of Fibulin-5 in Metastatic Organ Colonization

(2011) H. Devitt Moller et al.   MOLECULAR CANCER RESEARCH

A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells

(2011) Kim J. Png et al.   NATURE

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

Interactions between cancer stem cells and their niche govern metastatic colonization

(2011) Ilaria Malanchi et al.   NATURE

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

(2011) Mina J Bissell et al.   NATURE MEDICINE

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

(2011) Thordur Oskarsson et al.   NATURE MEDICINE

VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization

(2011) J. T. O'Connell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

(2011) C. L. Chaffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Mesenchymal Transition and Dissemination of Cancer Cells Is Driven by Myeloid-Derived Suppressor Cells Infiltrating the Primary Tumor

(2011) Benjamin Toh et al.   PLOS BIOLOGY

Reprogramming Human Cancer Cells in the Mouse Mammary Gland

(2010) K. M. Bussard et al.   CANCER RESEARCH

Metastatic Growth from Dormant Cells Induced by a Col-I-Enriched Fibrotic Environment

(2010) D. Barkan et al.   CANCER RESEARCH

Reciprocal Activation of Prostate Cancer Cells and Cancer-Associated Fibroblasts Stimulates Epithelial-Mesenchymal Transition and Cancer Stemness

(2010) E. Giannoni et al.   CANCER RESEARCH

Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content

(2010) Salvatore Pece et al.   CELL

The perivascular niche microenvironment in brain tumor progression

(2010) Nikki A Charles et al.   CELL CYCLE

Interaction between lung cancer cells and astrocytes via specific inflammatory cytokines in the microenvironment of brain metastasis

(2010) Toshihiro Seike et al.   CLINICAL & EXPERIMENTAL METASTASIS

Framework models of tumor dormancy from patient-derived observations

(2010) Christoph A Klein   CURRENT OPINION IN GENETICS & DEVELOPMENT

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells

(2010) Jörg Schrader et al.   HEPATOLOGY

High-throughput live-cell imaging reveals differential inhibition of tumor cell proliferation by human fibroblasts

(2010) Emilie Flaberg et al.   INTERNATIONAL JOURNAL OF CANCER

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

Latent Bone Metastasis in Breast Cancer Tied to Src-Dependent Survival Signals

(2009) Xiang H.-F. Zhang et al.   CANCER CELL

Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

(2009) Janine T. Erler et al.   CANCER CELL

Tumor Self-Seeding by Circulating Cancer Cells

(2009) Mi-Young Kim et al.   CELL

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

High expression of Snail mRNA in blood from hepatocellular carcinoma patients with extra-hepatic metastasis

(2009) Ae Lyoung Min et al.   CLINICAL & EXPERIMENTAL METASTASIS

ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis

(2009) X. Lu et al.   GENES & DEVELOPMENT

Incorporation of Tenascin-C into the Extracellular Matrix by Periostin Underlies an Extracellular Meshwork Architecture

(2009) Isao Kii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

(2009) Sunhwa Kim et al.   NATURE

Real-time imaging reveals the single steps of brain metastasis formation

(2009) Yvonne Kienast et al.   NATURE MEDICINE

Cancer micrometastases

(2009) Klaus Pantel et al.   Nature Reviews Clinical Oncology

A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth

(2009) Binzhi Qian et al.   PLoS One

Integrin  1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs

(2009) T. Shibue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Metastatic Outgrowth from Single Dormant Tumor Cells by Targeting the Cytoskeleton

(2008) D. Barkan et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

(2008) David Padua et al.   CELL

Reactive glia are recruited by highly proliferative brain metastases of breast cancer and promote tumor cell colonization

(2008) Daniel P. Fitzgerald et al.   CLINICAL & EXPERIMENTAL METASTASIS

Regulation of scar formation by vascular endothelial growth factor

(2008) Traci A Wilgus et al.   LABORATORY INVESTIGATION

The S100A8–serum amyloid A3–TLR4 paracrine cascade establishes a pre-metastatic phase

(2008) Sachie Hiratsuka et al.   NATURE CELL BIOLOGY

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

(2008) Ittai Ben-Porath et al.   NATURE GENETICS

Cancer as an overhealing wound: an old hypothesis revisited

(2008) Matthias Schäfer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular Basis of Metastasis

(2008) Anne C. Chiang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Endothelial Progenitor Cells Control the Angiogenic Switch in Mouse Lung Metastasis

(2008) D. Gao et al.   SCIENCE