Article
Endocrinology & Metabolism
Richard C. Wang, Eunice E. Lee, Nicole De Simone, Gauri Kathote, Sharon Primeaux, Adrian Avila, Dong-Min Yu, Mark Johnson, Levi B. Good, Vikram Jakkamsetti, Ravi Sarode, Alice Ann Holland, Juan M. Pascual
Summary: Red blood cells in the brain have close contact with capillary endothelium, providing a pathway for metabolic substrate transfer. Replacing deficient red cells in individuals with glucose transporter I deficiency through exchange transfusion can improve cognitive and quality-of-life measures.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Medicine, Research & Experimental
Hamideh Keshavarz, Lisa M. Meints, Morgan K. Geiger, Kurt R. Zinn, Dana M. Spence
Summary: Leptin plays a role in delivering C-peptide and Zn2+ to red blood cells in a saturable and specific manner, with a separate binding site for the leptin/C-peptide complex. The presence of leptin/C-peptide/Zn2+ leads to an increase in ATP release from red blood cells in a concentration-dependent manner.
MOLECULAR PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Xiang Li, Liyan Li, Xiaodong Wu, Bing Wen, Wan Lin, Yufei Cao, Lei Xie, Hefeng Zhang, Geng Dong, Enmin Li, Liyan Xu, Yinwei Cheng
Summary: The study reveals a novel anti-tumour mechanism of F806 in inhibiting the growth of ESCC cells by targeting and promoting the internalization and degradation of GLUT1, and by inducing glucose starvation response and inhibiting energy production.
Article
Cell & Tissue Engineering
Cuicui Wang, Jun Ying, Xiangfeng Niu, Xiaofei Li, Gary J. Patti, Jie Shen, Regis J. O'Keefe
Summary: Glut1-mediated glucose metabolism plays pivotal and distinct roles in two postnatal cartilage compartments, affecting cell proliferation, matrix production, and disease susceptibility. Despite disparities in glucose metabolism between growth plate and articular cartilage chondrocytes, both types demonstrate metabolic plasticity in the absence of glucose availability.
Article
Cell Biology
Junxia Feng, Meizhi Lu, Wenhao Li, Jingchun Li, Ping Meng, Zukai Li, Xuejuan Gao, Yunfang Zhang
Summary: This study found that PPAR gamma can inhibit the progression of high glucose-induced peritoneal fibrosis by increasing GLUT1 expression and suppressing peritoneal mesothelial cell proliferation.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Marcelo Villagran, Carlos F. Burgos, Coralia I. Rivas, Lorena Mardones
Summary: The residues involved in the transport of dehydroascorbic acid by human GLUT1 were identified through docking studies, and functional studies further confirmed the importance of these residues in the uptake of dehydroascorbic acid and glucose analogs. The results provide structural determinants of oxidized vitamin C's transport via GLUT1 for the first time.
Article
Biochemistry & Molecular Biology
Wiem Haj Ahmed, Nathalie Boulet, Anais Briot, Barry J. Ryan, Gemma K. Kinsella, Jeffrey O'Sullivan, Francisco Les, Josep Mercader-Barcelo, Gary T. M. Henehan, Christian Carpene
Summary: Caffeine has direct inhibitory effects on glucose transport and lipogenesis in adipocytes. The findings suggest the potential of caffeine in the treatment or prevention of obesity complications.
Article
Biochemistry & Molecular Biology
Benjamin R. E. Harris, Ye Zhang, Jianxin Tao, Renhui Shen, Xiaoqian Zhao, Margot P. Cleary, Tong Wang, Da-Qing Yang
Summary: Enhanced glucose uptake in cancer cells is closely correlated with poor prognosis, and the protein kinase ATM plays a key role in insulin-mediated glucose uptake. Inhibition of ATM by KU-55933 inhibits glucose uptake and glycolysis, induces apoptosis, and inhibits motility of cancer cells with overactivated Akt, showing potential as a therapeutic agent against cancer.
Article
Biochemistry & Molecular Biology
Xiaotong Chen, Yunshuo Zhao, Chuanjie He, Guanfei Gao, Jiao Li, Lu Qiu, Xiaoxi Wang, Yanfeng Gao, Yuanming Qi, Kai Sun, Jiangfeng Du
Summary: In this study, a novel GLUT1 inhibitor (SMI277) was synthesized and identified, which showed stronger inhibitory activity to glucose uptake and could inhibit cell proliferations and induce apoptosis of tumor cells. SMI277 was also able to slow down tumor growth in a mouse model and reduce tumor size.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Cell Biology
Fang Wang, Qing Zhang, Hailing Zhang, Xiaogai Qiao, Xia Zhang, Ke Zhang, Xiaoli Gu, Lihong Wang, Jinquan Cui
Summary: The study found that MUC16 promotes proliferation and disease progression in EOC by regulating GLUT1 expression.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Zhenxing Zhang, Xin Li, Fan Yang, Chao Chen, Ping Liu, Yi Ren, Pengkai Sun, Zixiong Wang, Yongping You, Yi-Xin Zeng, Xinjian Li
Summary: This study demonstrates that DHHC9-mediated GLUT1 palmitoylation at Cys207 is essential for plasma membrane localization of GLUT1 and for tumor growth in glioblastoma cells. The findings suggest a potential therapeutic target for targeting GLUT1 in cancer treatment.
NATURE COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Qun Lou, Meichen Zhang, Yanmei Yang, Yanhui Gao
Summary: Long term low dose exposure to arsenic can lead to cell proliferation and malignant transformation. In this study, it was found that low dose exposure to arsenic trioxide increased glucose uptake and promoted cell viability and DNA synthesis. The activation of AKT induced by arsenic trioxide upregulated the expression of GLUT1 on the plasma membrane, enhancing glucose uptake and cell proliferation.
Article
Pharmacology & Pharmacy
Claudia Silva, Nelson Andrade, Joao Tiago Guimaraes, Emilia Patricio, Fatima Martel
Summary: Obesity and T2DM are linked to increased cancer incidence and mortality, including breast cancer. This study explores the impact of high glucose, insulin, leptin, TNF-alpha, INF-gamma, and oxidative stress on breast cancer and non-cancer cell lines, and suggests that changes in glucose uptake mediated by GLUT1 may contribute to cancer progression. Additionally, the GLUT1 inhibitor BAY-876 shows promise as a potential new anticancer agent against breast cancer.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Liao Y. Chen
Summary: This article presents a quantitative investigation of the GLUT1 glucose transporter using molecular dynamics simulations. It provides insights into the mechanism of glucose diffusion across the cell membrane and quantitatively characterizes the transport pathway. The study highlights the physiological and pathological relevance of GLUT1 in the human body.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2022)
Article
Multidisciplinary Sciences
Monira Obaid, S. M. Nashir Udden, Prasanna Alluri, Subhrangsu S. Mandal
Summary: The study demonstrates that during inflammation, HOTAIR plays a key role in regulating Glut1 expression and glucose uptake by activating NF-kB, thereby controlling metabolic programming in immune cells.
SCIENTIFIC REPORTS
(2021)