Article
Biochemistry & Molecular Biology
Teerapich Kasemsuk, Natthiya Saehlim, Patcharee Arsakhant, Gunya Sittithumcharee, Seiji Okada, Rungnapha Saeeng
Summary: A novel series of acanthoic acid analogues containing triazole moiety were synthesized, with 3d exhibiting the strongest cytotoxic activity. Computational studies showed that 3d has high binding energy with CDK-2 and EGFR protein kinases, indicating its potential as an anticancer agent.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Jia-Yi Dou, Yu-Chen Jiang, Zhen-Yu Cui, Li-Hua Lian, Ji-Xing Nan, Yan-Ling Wu
Summary: Acanthoic acid (AA), isolated from the root bark of Acanthopanax koreanum Nakai, exhibits a wide range of pharmacological activities and targets multiple signaling pathways. Studies have also focused on structural modifications of AA to enhance its pharmacological effects.
Article
Infectious Diseases
Andrey Moacir do Rosario Marinho, Claudia Maria S. C. de Oliveira, Joao Victor Silva-Silva, Samara C. Anchieta de Jesus, Jose Edson S. Siqueira, Luana C. de Oliveira, Jessica Fernandes Auzier, Liviane N. Soares, Maria Lucia Belem Pinheiro, Sebastiao C. Silva, Livia S. Medeiros, Emmanoel V. Costa, Patricia S. Barbosa Marinho
Summary: In this study, acanthoic acid (AA) was biotransformed using the fungus Xylaria sp., resulting in the synthesis of a novel compound 3 fi,7 fi-dihydroxyacanthoic acid (S1). The activity of S1 against Escherichia coli and its interactions with superoxide dismutase 1 (SOD1) were investigated using molecular docking. The results suggest that SOD1 enzyme could be a potential target for the antioxidant activity of S1.
Review
Chemistry, Multidisciplinary
Amandine L. Flourat, Jeanne Combes, Claire Bailly-Maitre-Grand, Kevin Magnien, Arnaud Haudrechy, Jean-Hugues Renault, Florent Allais
Summary: p-Hydroxycinnamic acids are phenolic compounds involved in lignin biosynthesis pathway, with attractive properties such as antioxidant, anti-UV, and anticancer activities, and are used as building blocks for various industries, but their production cost remains high.
Article
Chemistry, Multidisciplinary
Sofia-Maria Ioannidou, Jose Pablo Lopez-Gomez, Joachim Venus, Miguel Angel Valera, Vera Essmann, Irantzu Alegria-Dallo, Ioannis K. Kookos, Apostolis Koutinas, Dimitrios Ladakis
Summary: Process design, techno-economic assessment, and life cycle assessment methods were used to evaluate four biorefinery concepts utilizing the organic fraction of municipal solid waste (OFMSW) for the production of biosurfactants and lactic acid (LA), succinic acid (SA), hot melt adhesives (HMAs), or polyurethane urea dispersions (PUDs). LA and SA were produced through fermentation using sugar-rich OFMSW enzymatic hydrolysates, while biosurfactants were produced from OFMSW-derived lipids and proteins and bacterial biomass remaining at the end of fermentation. OFMSW-derived SA replaced fossil-based SA and adipic acid in PUDs production. The study employed process design for equipment sizing and costing, as well as the estimation of material and energy balances using experimental results obtained during the H2020 funded PERCAL project. HMAs and PUDs production could be profitable when biosurfactants are produced as co-products in OFMSW-based biorefineries, resulting in minimum selling prices (MSP) of $2.92 per kg (HMAs) and $1.95 per kg (PUDs) when considering biosurfactants market price of $4.1 per kg, OFMSW management fees of $0.035 per kg, and production capacities of SA and LA at economies of scale. If LA or SA are considered as final products together with biosurfactants, then the corresponding MSPs are $1.58 per kg (LA) and $2.14 per kg (SA). Five environmental indicators were estimated, considering either conventional electricity production mix (grid) or renewable electricity usage from photovoltaics. The proposed OFMSW-based biorefineries lead to 25-35% greenhouse gas emission savings per kg main product (or 0.95-2.06 kg CO2-eq per kg dry OFMSW) compared to conventional production of end-products and two OFMSW management practices based on either landfilling alone or combined composting (37.45%) and landfilling (62.55%). The results demonstrate that OFMSW-based biorefineries could lead to profitable and sustainable production of bio-based products and the utilization of OFMSW as feedstock.
Review
Biotechnology & Applied Microbiology
Huan Liu, Yuhan Jin, Renwei Zhang, Yuchen Ning, Yue Yu, Peng Xu, Li Deng, Fang Wang
Summary: Organic acids are important consumable materials with wide applications, and their global market is projected to reach $36.86 billion by 2026. To address environmental concerns and meet sustainable development goals, genetically-modified microbes are used for large-scale fermentative production of organic acids, replacing the traditional chemical catalysis process. However, low productivity has hindered the industrial-scale application of bio-based organic acids.
BIOTECHNOLOGY ADVANCES
(2023)
Article
Nutrition & Dietetics
Maciej Zietek, Zbigniew Celewicz, Justyna Kikut, Malgorzata Szczuko
Summary: The study analyzed the correlation of SCFAs with lipid and hepatic metabolism during pregnancy in relation to the body weight of pregnant women. Significant differences in concentrations of certain SCFAs were found in overweight and obese women compared to the control group, with some SCFAs being associated with hepatic lipid metabolism and CRP concentrations.
Article
Gastroenterology & Hepatology
Heidi L. Doden, Patricia G. Wolf, H. Rex Gaskins, Karthik Anantharaman, Joao M. P. Alves, Jason M. Ridlon
Summary: Intestinal microbiota can convert the orientation of bile acids, altering their water solubility and toxicity, while relevant genes have been identified and shown potential importance.
Article
Chemistry, Applied
M. T. Ngo Njembe, E. Dormal, C. Gardin, E. Mignolet, C. Debier, Y. Larondelle
Summary: This study showed that supplementing laying hens' feeds with flaxseeds combined with oil from Ricinodendron heudelotii or Punica granatum seeds can increase the egg content of beneficial fatty acids, without affecting the conversion rate of ALA to DHA. Both oils efficiently converted into RmA, with Punica granatum seed oil having a higher accumulation of PunA in eggs.
Article
Agriculture, Dairy & Animal Science
J. E. Rico, W. A. Myers, A. Javaid, R. Gervais, J. W. McFadden
Summary: The digestibility and content of 16C and 22C fatty acids in milk fat are influenced by different treatments, with 1-carbon donors having no effect on the digestibility of 22C fatty acids. The content and yield of 16:0 and 22:6 in milk fat show significant differences between different treatments.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Plant Sciences
Wei-Jian Sun, Jiu-Cheng Zhang, Xing-Long Ji, Zi-Quan Feng, Xun Wang, Wen-Jing Huang, Chun-Xiang You, Xiao-Fei Wang, Yu-Jin Hao
Summary: The study found that the application of low nitrate can alleviate iron chlorosis symptoms in apple leaves and promote iron uptake in roots. In addition, low nitrate also increases the accumulation of citrate and abscisic acid in roots, facilitating iron transport.
PLANT CELL AND ENVIRONMENT
(2021)
Review
Biochemistry & Molecular Biology
Marius Mioc, Alexandra Prodea, Roxana Racoviceanu, Alexandra Mioc, Roxana Ghiulai, Andreea Milan, Mirela Voicu, Gabriel Mardale, Codruta Soica
Summary: This paper summarizes the recent studies on the mechanism of action of several triterpenic acids, which have various biological activities and are important for drug development and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Scott A. Backer, Lyndsay Leal
Summary: Consumer pressure for transparency on the origin and fate of ingredients in home and personal care products is driving the growth of sustainable products in this market. Life cycle assessment (LCA) is a methodology used to determine the environmental impact of products, but often overlooks the end of life stage. While consumers demand biodegradable materials, the release of carbon dioxide during biodegradation contradicts carbon reduction methods. This Account explores the impact of biodegradation on the circular economy and discusses the development of biodegradable alternatives in the home and personal care markets.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Janusz Malarz, Yulia V. Yudina, Anna Stojakowska
Summary: Plant-derived antioxidants are important for human health and stress tolerance in both plants and humans. Hairy roots, transformed by Rhizobium rhizogenes, have been studied as potential sources of plant metabolites with medical applications for almost forty years. They have also shown value in crop improvement and secondary metabolism research. Hairy roots may become more important as a sustainable source of biologically active compounds due to biodiversity decline caused by climate change and overexploitation of natural resources. This review focuses on the efficient production of phenolic compounds in hairy roots and efforts to increase yield, including genetic transformation of crop plants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Yuxun Zhu, Taro Shiraishi, Jianwen Lin, Keito Inaba, Atsuro Ito, Yusuke Ogura, Makoto Nishiyama, Tomohisa Kuzuyama
Summary: Phosphonates often exhibit biological activities by mimicking the phosphates and carboxylates of biological molecules. This study proposes a complete biosynthetic pathway for the phosphonate phosphonothrixin (PTX), highlighting an unprecedented biosynthetic strategy for natural products, where two distinct TPP-dependent enzymes divide the work to transfer an acetyl group.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Medicine, Research & Experimental
Pongvit Nugitrangson, Songchan Puthong, Tawin Iempridee, Wittaya Pimtong, Surachai Pornpakakul, Chanpen Chanchao
EXPERIMENTAL BIOLOGY AND MEDICINE
(2016)
Article
Plant Sciences
Suphongphan Srisurichan, Surachai Pornpakakul
PHYTOCHEMISTRY LETTERS
(2015)
Article
Biochemistry & Molecular Biology
Jatupol Liangsakul, Suphongphan Srisurichan, Surachai Pornpakakul
Article
Plant Sciences
Suphongphan Srisurichan, Jittra Piapukiew, Songchan Puthong, Surachai Pornpakakul
PHYTOCHEMISTRY LETTERS
(2017)
Article
Crystallography
Srinuan Tansuwan, Porntana Chanaprat, Thapong Teerawatananond, Nongnuj Muangsin, Surachai Pornpakakul
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE
(2010)
Article
Chemistry, Medicinal
Sunisa Suwancharoen, Orawan Chonvanich, Sophon Roengsumran, Surachai Pornpakakul
CHEMISTRY OF NATURAL COMPOUNDS
(2012)
Article
Chemistry, Applied
Jaraslak Pechwang, Prakitsin Sihanonth, Surachai Pornpakakul, Nongnuj Muangsin, Jittra Piapukiew, Alisa Vangnai, Narongsak Chaichit, Siriporn Chuchawankul, Amorn Petsom
NATURAL PRODUCT RESEARCH
(2010)
Article
Biochemistry & Molecular Biology
Suphongphan Srisurichan, Songchan Puthong, Surachai Pornpakakul
Article
Chemistry, Organic
Jatupol Liangsakul, Surachai Pornpakakul, Ek Sangvichien, Nongnuj Muangsin, Prakitsin Sihanonth
TETRAHEDRON LETTERS
(2011)
Article
Chemistry, Organic
Sunisa Suwancharoen, Surachai Pornpakakul, Nongnuj Muangsin
TETRAHEDRON LETTERS
(2012)
Article
Chemistry, Applied
Natta Rattanapanya, Surachai Pornpakakul
Summary: The mixture of p-toluenesulfonic acid and sulfuric acid showed good performance as a catalyst in transesterification and etherification processes, resulting in fast reaction rates and high conversions. The catalyst could be reused for 6 cycles and offers an attractive route for converting biodiesel by-products into valuable fuel additives.
JOURNAL OF OLEO SCIENCE
(2021)
Article
Multidisciplinary Sciences
Thanavadee Kor-arnan, Thanawan Rojpitikul, Preecha Phuwapraisirisan, Surachai Pornpakakul, Pattara Thiraphibundet
MAEJO INTERNATIONAL JOURNAL OF SCIENCE AND TECHNOLOGY
(2019)
Article
Multidisciplinary Sciences
Jeroen Bogie, Cindy Hoeks, Melissa Schepers, Assia Tiane, Ann Cuypers, Frank Leijten, Yupyn Chintapakorn, Thiti Suttiyut, Surachai Pornpakakul, Dicky Struik, Anja Kerksiek, Hong-Bing Liu, Niels Hellings, Pilar Martinez-Martinez, Johan W. Jonker, Ilse Dewachter, Eric Sijbrands, Jochen Walter, Jerome Hendriks, Albert Groen, Bart Staels, Dieter Luetjohann, Tim Vanmierlo, Monique Mulder
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Nattachai Kengpipat, Surachai Pornpakakul, Jittra Piapukiew, Thanapat Palaga, Geoff Robson, Anthony J. S. Whalley, Prakitsin Sihanonth
CHIANG MAI JOURNAL OF SCIENCE
(2016)
Article
Chemistry, Medicinal
Wichuta Kuanhut, Thammarat Aree, Surachai Pornpakakul, Pattara Sawasdee
NATURAL PRODUCT COMMUNICATIONS
(2014)
