Article
Nutrition & Dietetics
Mona S. Almujaydil, Reham M. Algheshairy, Raghad M. Alhomaid, Hend F. Alharbi, Hoda A. Ali
Summary: This study assessed the protective effects of Nigella sativa floral honey (NS floral honey) and multi-floral honey (M-floral honey) compared to Nigella sativa oil (NS oil) against azathioprine-induced testicular degeneration in rats. Both NS floral honey and NS oil partially restored testicular function and improved sperm quality, while the effects of M-floral honey were inconclusive. Further clinical studies are needed to investigate the bioactive constituents of these substances.
Review
Pharmacology & Pharmacy
M. S. Almuhayawi
Summary: Skin rupture leads to bacterial colonization and can develop into invasive and systemic infections. Multi-drug resistant bacteria are a global concern, and alternative therapies can minimize antibiotic usage by addressing antibiotic resistance. Nigella sativa has been shown to have antibacterial properties and promote wound healing. This review summarizes recent studies on Nigella sativa's efficacy in wound healing.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Food Science & Technology
Mehmet Kemal, Ulku Zeynep Ureyen Esertas, Esra Demir Kanbur, Yakup Kara, Ali Erdem Ozcelik, Zehra Can, Sevgi Kolayli
Summary: This study investigated the compositions, antioxidant and antimicrobial properties of black cumin honey from the Burdur region of Turkiye. The honey samples had various physicochemical properties, phenolic contents, and exhibited high antimicrobial activities against several bacteria. They also showed significant antioxidant capacities. The phenolic composition of the samples was analyzed using HPLC-PDA method and several common components were identified.
Review
Biochemistry & Molecular Biology
Abdalsalam Kmail, Omar Said, Bashar Saad
Summary: This review examines the latest research on how thymoquinone accelerates wound healing and the mechanisms behind its effectiveness. Thymoquinone has antimicrobial, anti-inflammatory, and antineoplastic activities, making it a potential remedy for skin pathologies. There is sufficient evidence to support the effectiveness of thymoquinone in promoting wound healing, but there is no consensus on the most effective concentrations.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Saad A. Alkahtani, Ali Mohamed Alshabi, Basel A. Abdel-Wahab, Adel Aljadaan, Ibrahim Ahmed Shaikh, Masood Medleri Khateeb, Mohammed Shafiuddin Habeeb
Summary: The study found that Nigella sativa oil and honey have antinociceptive effects, and concurrent administration enhances the antinociceptive effect, shortens the onset time, and prolongs the duration.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Mahmoud Abd-Elkareem, Mahmoud Soliman, Mokhless A. M. Abd El-Rahman, Nasser S. Abou Khalil
Summary: The study found that Nigella sativa seeds can alleviate MSG-induced renal toxicity in rats. Nigella sativa seeds improved oxidative stress and histopathological damage caused by MSG through their antioxidant and anti-apoptotic effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Cansu Aras, Elif Tumay Ozer, Gokhan Goktalay, Gulbahar Saat, Esra Karaca
Summary: Polyurethane/Nigella sativa oil nanofibrous mat has significant antibacterial activity and promotes wound healing effectively. The release of NSO from the mat is controlled, and it shows no cytotoxicity.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Article
Environmental Sciences
Doaa A. Madkour, Mohamed M. Ahmed, Sahar H. Orabi, Samy M. Sayed, Reda M. S. Korany, Hanem K. Khalifa
Summary: The study demonstrated that Nigella sativa oil (NSO) has a protective effect against emamectin benzoate (EMB) induced neurotoxicity through its antioxidant, anti-inflammatory, and anti-apoptotic activities. The findings suggest NSO as a potential therapeutic agent for EMB-induced neurotoxicity.
ENVIRONMENTAL TOXICOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Limberg Jaldin-Crespo, Nataly Silva, Jessica Martinez
Summary: This article summarizes the latest therapies for wound healing based on bionanomaterials assisted by honey and propolis, emphasizing their anti-inflammatory, antimicrobial, antioxidant, collagen synthesis stimulation, cell proliferation, and angiogenic effects. Nanomaterials enable targeted and continuous delivery at the site of the wound, avoiding systemic adverse effects.
Review
Polymer Science
Siti Nor Najihah Yasin, Zulfahmi Said, Nadia Halib, Zulaiha A. Rahman, Noor Izzati Mokhzani
Summary: Excellent wound dressings should have crucial components such as high porosity, non-toxicity, high water absorption, and the ability to maintain a moist environment and promote wound healing. However, current wound dressings have limitations in antibacterial, anti-inflammatory, and antioxidant activity, frequent dressing changes, low biodegradability, and poor mechanical properties. Hydrogels, including natural, synthetic, or hybrid polymers, have shown potential as wound dressings by providing a moist environment, a protective barrier against infections, and pain relief. Honey-based hydrogel dressing, with its anti-inflammatory, antibacterial, and antioxidant properties, exhibits excellent characteristics including biodegradability, biocompatibility, cell proliferation, inhibition of bacterial growth, and accelerated wound healing. This review aims to showcase the potential of honey-based hydrogel dressings in wound healing applications and complement existing studies on their implementation.
Article
Pharmacology & Pharmacy
G. Ben Salah, S. Jebahi, S. Bessaleh, M. A. Ahmad, H. Khireddine, M. Abdulghani, N. Mejri
Summary: Researchers prepared a natural wound dressing composed of gelatin and chitosan, with the addition of Nigella sativa oil. The composite dressing exhibited strong antioxidant and antibiofilm activities, and significantly accelerated wound healing and tissue repair.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Materials Science, Textiles
Ayub Ali, Md Mohebbullah, Md Abdus Shahid, Sadikul Alam, Md Nur Uddin, Md Sumon Miah, Mohammad Salman Ibna Jamal, Md Shablu Khan
Summary: Incorporating Nigella sativa extract into PVA-based nanofiber mats enhances their antibacterial and moisture management properties, making them a promising material for wound dressing applications.
JOURNAL OF THE TEXTILE INSTITUTE
(2021)
Article
Food Science & Technology
Sevgi Kolayli, Gamze Kazaz, Asli Ozkok, Merve Keskin, Yakup Kara, Esra Demir Kanbur, Omer Erturk
Summary: Black cumin honey has high antioxidant and antimicrobial properties, making it suitable for medicinal use. This study evaluated the characteristics of black cumin honey and identified ellagic acid and pinocembrin as major components. The honey was found to be especially effective against Listeria monocytogenes, Staphylococcus aureus, and Enterococcus faecalis.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Klaudia Ciesielska-Figlon, Karolina Wojciechowicz, Anna Wardowska, Katarzyna Aleksandra Lisowska
Summary: Background: Nigella sativa has been traditionally used for medicinal purposes and has known antibacterial, virucidal, fungicidal, and antiparasitic properties. However, studies on its immunomodulatory effects are limited. This review examines in vitro and in vivo research supporting the role of Nigella sativa in modulating immune responses. The results suggest its potential as a therapeutic agent for regulating immune reactions.
Review
Pharmacology & Pharmacy
Joel Yupanqui Mieles, Cian Vyas, Enes Aslan, Gavin Humphreys, Carl Diver, Paulo Bartolo
Summary: Honey is experiencing a resurgence in evaluation for antimicrobial and wound healing applications due to its ability to inhibit various bacteria, fungi, and viruses, as well as promote wound healing. Its activity is attributed to the enzymatic generation of hydrogen peroxide and other non-peroxide factors. The development of tissue engineering approaches has been driven by the difficulty of delivering honey's active ingredients to the wound site.
Article
Integrative & Complementary Medicine
Zahra Sadeghnejad, Arezou Karampourian, Seyed Reza Borzou, Mahmoud Gholyaf, Younes Mohammadi, Rasoul Hadadi
Summary: The study found that the use of ostrich oil significantly reduced pruritus severity in hemodialysis patients after 3-4 weeks of treatment. However, there was no significant impact on the quality of life between the ostrich oil group and the placebo group.
COMPLEMENTARY MEDICINE RESEARCH
(2021)
Article
Immunology
Saman Saadat, Pezhman Karami, Mohammad Jafari, Mahdi Kholoujini, Zahra Rikhtegaran Tehrani, Younes Mohammadi, Mohammad Yousef Alikhani
PATHOGENS AND DISEASE
(2020)
Review
Oncology
Chiman Mohammadi, Saeideh Gholamzadeh Khoei, Nashmin Fayazi, Younes Mohammadi, Rezvan Najafi
Summary: The study found that miRNAs are associated with radioresistance and radiosensitivity in cancer treatment, with miR-21 showing different effects in different cancers. The results suggest that miRNAs could be used as theragnostic biomarkers to predict and monitor clinical response to radiotherapy.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Medicine, General & Internal
Seyed Mohammadreza Javadi, Mohammad Abdolahad, Solmaz Hashemi, Mohammadali Khayamian, Mohammad Salemizadeh Parizi, Shohreh Vanaei, Hamidreza Mirzaei, Shabnam Jeibouei, Ali Hojat, Hakimeh Zali, Seied Rabi Mahdavi, Mohammad Esmaeil Akbari
Summary: This study investigated the effect of post intraoperative radiotherapy wound fluid secretion (PIWFS) on tumor cells and found that PIWFS can lead to the transformation of tumor cells into a more invasive and proliferative state.
ARCHIVES OF IRANIAN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Shabnam Jeibouei, Ali Hojat, Ebrahim Mostafavi, Amir Reza Aref, Alireza Kalbasi, Vahid Niazi, Mohammad Ajoudanian, Farzaneh Mohammadi, Fariba Saadati, Seyed Mohammadreza Javadi, Forough Shams, Maryam Moghaddam, Farshid Karami, Kazem Sharifi, Farid Moradian, Mohammad Esmaeil Akbari, Hakimeh Zali
Summary: This study investigated the effects of intraoperative radiotherapy (IORT)-induced wound fluid on tumor progression. The findings showed that treatment with IORT-induced wound fluid increased cell viability in tumor spheroids, but the effects on cell lines depended on the type of cells and incubation times. Both types of wound fluids inhibited tumor cell migration and invasion, and altered the cell cycle and expression levels of related proteins. The study also suggested that a microfluidic system may be a better 3D model for studying tumor conditions than traditional 2D cell culture.
SCIENTIFIC REPORTS
(2022)
Review
Public, Environmental & Occupational Health
Majid Barati, Saeed Bashirian, Younes Mohammadi, Babak Moeini, Amirabbas Mousali, Maryam Afshari
Summary: This study reviewed relevant literature to identify factors affecting substance use relapse based on the ecological approach. The findings showed that factors influencing substance use relapse exist at different levels of the ecological model, such as intrapersonal factors like unpleasant emotions, interpersonal factors like addicted friends and family disputes, organizational factors like poor follow up, community factors like society rejection, and environmental factors like drug availability and unhealthy environment.
JOURNAL OF PUBLIC HEALTH-HEIDELBERG
(2023)
Article
Pharmacology & Pharmacy
Ali Hojat, Shabnam Jeibouei, Amir Reza Aref, Alireza Kalbasi, Maryam Moghaddam, Farzaneh Mohammadi, Seyed Mohammadreza Javadi, Mohammad Ajoudanian, Kazem Sharifi, Hakimeh Zali, Mohammad Esmaeil Akbari
Summary: The study utilized a 3D model to mimic the tumor microenvironment and found that most breast cancer patients benefit from surgical wound healing, but clearing surgical-induced serum may not be an effective method to inhibit tumors in all patients.
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2021)
Article
Oncology
Seyedmohammadreza Javadi, Mohammad Esmaeil Akbari, Solmaz Hashemi, Farid Moradian, Atieh Akbari, Farzane Mohamadi, Maryam Khayamzadeh
Summary: The study showed that in early-stage breast cancer patients, there was no significant difference in DFS between LALND and ALND. Additionally, in patients without lymph node involvement, there was no difference in OS between the LALND group and ALND group, but in patients with axillary lymph node metastasis, the best results were seen in those who had 7-8 lymph nodes removed.
INTERNATIONAL JOURNAL OF CANCER MANAGEMENT
(2021)
Article
Oncology
Solmaz Hashemi, Seyedmohammadreza Javadi, Mohammad Esmaeil Akbari, Hamidreza Mirzaei, Seied Rabi Mahdavi
Summary: The study indicates that intraoperative radiotherapy may be more favorable in treating breast cancer compared to external beam radiation therapy, as it could help patients to save their breast and achieve better outcomes, especially in delivering radical dose.
INTERNATIONAL JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Psychiatry
Alireza Khalilian, Davoud Ahmadimoghaddam, Shiva Saki, Younes Mohammadi, Maryam Mehrpooya
Summary: The study found that compared to placebo, mirtazapine is more effective and safe in treating patients with IBS-D, significantly reducing symptom severity, improving quality of life, and reducing anxiety symptoms.
BIOPSYCHOSOCIAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Jamal Ahmadpoor, Younes Mohammadi, Ali Reza Soltanian, Jalal Poorolajal
Summary: The study revealed that more than one-third of university students not only suffer from certain psychiatric disorders but also engage in at least one risky behavior.
JOURNAL OF PUBLIC HEALTH-HEIDELBERG
(2021)
Article
Respiratory System
Homa Serpoosh, Yadollah Hamidi, Payman Eini, Younes Mohammadi
ADVANCES IN RESPIRATORY MEDICINE
(2020)
Article
Substance Abuse
Amirabbas Mousali, Latif Moradveisi, Majid Barati, Babak Moeini, Saeed Bashirian, Manoj Sharma, Younes Mohammadi
ADDICTA-THE TURKISH JOURNAL ON ADDICTIONS
(2020)
Review
Pediatrics
Maryam Soori, Younes Mohammadi, Mohammad Taghi Goodarzi, Minoo Mahmoodi
JOURNAL OF PEDIATRICS REVIEW
(2020)
Article
Chemistry, Medicinal
Seyyede-Nadia Hosseini-Ghalibaf, Akram Ranjbar, Fatemeh Yasrebifar, Ehsan Mirzaei, Mahtabalsadat Mirjalili, Younes Mohammadi, Maryam Mehrpooya
NATURAL PRODUCTS JOURNAL
(2020)
