Dose-response effect of a novel functional fibre, PolyGlycopleX®, PGX®, on satiety

The objective of this research was to determine the dose-response effects of a palatable, viscous and gel forming fibre, PolyGlycopleX (R) (PGX (R)), [(alpha-D-glucurono-alpha-manno-beta-D-manno-beta-D-gluco), (alpha-Lgulurono-beta-D mannurono), (beta-D-gluco-beta-D-mannan)] on satiety, and to gain insight into the underlying mechanisms that lead to appetite inhibition. Healthy subjects (n =10), aged between 20.3 and 29.2 years, consumed PGX, in granular form at 2.5, 5.0 and 7.5 g, and a 5g inulin control, with a standard breakfast. The PGX doses of 2.5 and 7.5 g mixed with water at the start of breakfast increased satiety (iAUC of 140.0 and 157.7, P=0.025 and 0.001, respectively) compared to the control. The most effective dose (7.5g) was palatable and corresponded to a 34% increase in fullness, measured using a visual analogue scale and incremental area under the curve, and resulted in a delayed postprandial glycaemic response when compared with the control. (c) 2014 The Authors. Published by Elsevier Ltd.