Journal
ACTA BIOMATERIALIA
Volume 10, Issue 10, Pages 4217-4225Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2014.07.007
Keywords
Foreign body reaction; Silicone; Surface modification; Phosphorylcholine; Capsular contracture
Funding
- Seoul National University Research Grant (Brain Fusion Program)
- National Research Foundation - Ministry of Education, Science, and Technology of Korea [NRF-2010-0007118]
- GAIA project - Ministry of Environment, Korea [G113-00055-3004-0]
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Despite their popular use in breast augmentation and reconstruction surgeries, the limited biocompatibility of silicone implants can induce severe side effects, including capsular contracture - an excessive foreign body reaction that forms a tight and hard fibrous capsule around the implant. This study examines the effects of using biomembrane-mimicking surface coatings to prevent capsular formations on silicone implants. The covalently attached biomembrane-mimicking polymer, poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), prevented nonspecific protein adsorption and fibroblast adhesion on the silicone surface. More importantly, in vivo capsule formations around PMPC-grafted silicone implants in rats were significantly thinner and exhibited lower collagen densities and more regular collagen alignments than bare silicone implants. The observed decrease in alpha-smooth muscle actin also supported the alleviation of capsular formations by the biomembrane-mimicking coating. Decreases in inflammation-related cells, myeloperoxidase and transforming growth factor-beta resulted in reduced inflammation in the capsular tissue. The biomembrane-mimicking coatings used on these silicone implants demonstrate great potential for preventing capsular contracture and developing biocompatible materials for various biomedical applications. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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