Journal
ACTA BIOMATERIALIA
Volume 10, Issue 10, Pages 4314-4322Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2014.06.009
Keywords
Superamphiphobic surfaces; Biomaterials; Superhydrophobic and biomimetic substrates; Microencapsulation; Polymer particles
Funding
- Fundacao para a Ciencia e Tecnologia (FCT) [PTDC/CTM-BIO/1814/2012]
- Spanish Ministerio de Economia y Competitividad [SAF 2011-22771, PRI-AIBPT-2011-1211]
- Xunta de Galicia [CN 2012/045]
- FEDER
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Superamphiphobic surfaces were evaluated as a tool to prepare spherical particles from polymers and solvents of very diverse nature, under mild conditions and with 100% drug encapsulation yield. Different from bioinspired superhydrophobic surfaces suitable only for aqueous dispersions, the superamphiphobic platforms allowed the formation of spherical droplets when solvents of any polarity were deposited onto them. Spherical poly(D,L-lactide-co-glycolide) (PLGA) particles were synthesized by placing drops of PLGA/ciprofloxacin suspensions in dioxane on a superamphiphobic surface followed by solvent evaporation. The particles prepared covering a wide range of PLGA/ciprofloxacin weight ratios delivered a 20% dose in the first 24 h and then sustained the release of the remaining drug for more than I month. The particles, both freshly prepared and after being 26 days in the release medium, showed efficiency against different types of microorganisms. The developed polymer- and solvent-independent approach could be useful for microencapsulation with very high efficiency of active substances of varied nature into size-tunable particles for a wide range of applications in an affordable and cost-effective manner. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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