Article
Engineering, Biomedical
Teng Ma, Yiming Hao, Shengyou Li, Bing Xia, Xue Gao, Yi Zheng, Liangwei Mei, Yitao Wei, Changbin Yang, Lei Lu, Zhuojing Luo, Jinghui Huang
Summary: In this study, a sequential oxygen supply system was developed using core-shell fibers to repair peripheral nerve defects. The system showed significant improvements in cell protection, angiogenesis, and nerve regeneration. The sequential oxygen supply conduits acted as oxygen suppliers for cells and resulted in similar functional outcomes as autografts.
Article
Engineering, Biomedical
Ohan S. Manoukian, Swetha Rudraiah, Michael R. Arul, Jenna M. Bartley, Jiana T. Baker, Xiaojun Yu, Sangamesh G. Kumbar
Summary: The study investigates novel nerve guidance conduits with aligned microchannel porosity delivering sustained-release of neurogenic 4-aminopyridine for peripheral nerve regeneration. Results show equivalency with autograft controls in terms of functional recovery, myelin development, and histological assessments. The aligned microchannel architecture of the conduit guides axons and the sustained release of 4-AP increases nerve conduction.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Zhi Yao, Weihao Yuan, Jiankun Xu, Wenxue Tong, Jie Mi, Pak-Cheong Ho, Dick Ho Kiu Chow, Ye Li, Hao Yao, Xu Li, Shunxiang Xu, Jiaxin Guo, Qingtang Zhu, Liming Bian, Ling Qin
Summary: In this study, an injectable hydrogel based on bisphosphonate was developed to sustainably release magnesium ions for peripheral nerve regeneration. The experimental results showed that magnesium ions promoted neurite outgrowth in a concentration-dependent manner by activating the PI3K/Akt signaling pathway and Sema5b. In a rat nerve defect model, filling the polycaprolactone conduit with magnesium-releasing hydrogel significantly enhanced axon regeneration and remyelination, leading to improved functional recovery.
Article
Engineering, Environmental
Ying Ma, Hao Wang, Qiqi Wang, Xiaodong Cao, Huichang Gao
Summary: This study developed a multi-channel nerve guidance conduit (NGC) with dual electrical activity of piezoelectricity and conductivity to enhance peripheral nerve regeneration. In vitro and in vivo experiments demonstrated that the electroactive NGC promoted cell proliferation, differentiation, axonal regeneration, and functional recovery of peripheral nerves, indicating its great potential in repairing peripheral nerve injuries.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Hui Zhang, Han Zhang, Huan Wang, Yuanjin Zhao, Renjie Chai
Summary: A novel silk fibroin-derived nerve guidance conduit (NGC) with internal-facing inverse opal structures is developed for local neurotrophic factor delivery and effective nerve regeneration. The NGC demonstrates excellent biocompatibility, suitable biodegradability, and spatial control over the distribution of loading factors, leading to enhanced therapeutic efficacy.
APPLIED MATERIALS TODAY
(2022)
Article
Cell Biology
Jie Yang, Chia-Chen Hsu, Ting-Ting Cao, Hua Ye, Jing Chen, Yun-Qing Li
Summary: A hyaluronic acid granular hydrogel was found to promote neuronal and astrocyte colony formation and axonal extension in vitro, mimicking an extracellular matrix structure for neural regeneration. Transplantation of the hydrogel nerve guidance conduit successfully repaired a 10-mm long sciatic nerve gap, showing similar regeneration of axons and myelin sheath, as well as recovery of electrophysiological and motor functions. The conduit outperformed bulk hydrogel or silicone tube transplant. These findings suggest that tissue-engineered nerve conduits with hyaluronic acid granular hydrogels effectively promote the morphological and functional recovery of injured peripheral nerves.
NEURAL REGENERATION RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Yongcong Fang, Chengjin Wang, Zibo Liu, Jeonghoon Ko, Li Chen, Ting Zhang, Zhuo Xiong, Lei Zhang, Wei Sun
Summary: In this study, a conductive multiscale filled NGC (MF-NGC) is developed, which significantly enhances peripheral nerve regeneration. The printed MF-NGCs possess good permeability, mechanical stability, and electrical conductivity, promoting the elongation and growth of Schwann cells and neurite outgrowth. Animal studies demonstrate that the MF-NGCs promote neovascularization and M2 transition, leading to improved peripheral nerve regeneration. This study demonstrates the feasibility of using 3D-printed conductive MF-NGCs with hierarchically oriented fibers as functional conduits.
Article
Engineering, Biomedical
Philip J. Hanwright, Chenhu Qiu, Jennifer Rath, Yang Zhou, Nicholas von Guionneau, Karim A. Sarhane, Thomas G. W. Harris, Gregory P. Howard, Harsha Malapati, Michael J. Lan, Sashank Reddy, Ahmet Hoke, Hai-Quan Mao, Sami H. Tuffaha
Summary: This study demonstrates the potential of a novel nanoparticle delivery system for targeted and sustained release of IGF-1, leading to improved motor recovery through amelioration of denervation-induced muscle atrophy and SC senescence and enhanced axonal regeneration.
Article
Engineering, Biomedical
Yaowei Xuan, Lin Li, Xuelai Yin, Dongming He, Siyao Li, Chenping Zhang, Yuan Yin, Wanlin Xu, Zhen Zhang
Summary: This study developed a nerve guidance conduit (NGC) based on bredigite (BRT) bioceramic, which could promote the repair of peripheral nerve injury. BRT bioceramic showed good biocompatibility and sustained release of beneficial ions for nerve repair. The experiments demonstrated that BRT-incorporating NGC could promote cell proliferation, myelination, and vascular formation, as well as improve electrophysiological performance and muscle atrophy in a rat sciatic nerve defect model.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Fangguo Liang, Yusheng Yang, Yuyong Chen, Jiajun Xie, Shencai Liu, Zilin Tan, Liangjie Tian, Zhiqiang Yu, Zhanjun Shi, Peigen Xie, Hong Ding, Qinfeng Yang
Summary: In this study, an electroconductive hydrogel loaded with sustained-release analgesic microspheres was designed as a promising therapeutic approach for diabetic peripheral nerve injury. In vitro and in vivo experiments demonstrated that this treatment strategy can enhance nerve regeneration, functional recovery, and pain relief in diabetic patients.
MATERIALS TODAY BIO
(2023)
Article
Cell & Tissue Engineering
Zheng Yang, Yang Yang, Yichi Xu, Weiqian Jiang, Yan Shao, Jiahua Xing, Youbai Chen, Yan Han
Summary: In this study, engineered exosomes were used as carriers to efficiently deliver NT-3 mRNA to recipient cells and promote nerve regeneration in a rat sciatic nerve defect model, demonstrating the potential for improving nerve regeneration.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Neurosciences
Feixiang Chen, Weihuang Liu, Qiang Zhang, Ping Wu, Ao Xiao, Yanan Zhao, Ying Zhou, Qiaona Wang, Yun Chen, Zan Tong
Summary: The study demonstrated that modulating the immune microenvironment by IL-17F could enhance peripheral nerve repair mediated by chitosan conduits. IL-17F knockout mice showed improved functional recovery and axonal regeneration, along with enhanced anti-inflammatory macrophages in the NGC repairing microenvironment. These findings suggest a promising approach to improve peripheral nerve regeneration.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Engineering, Environmental
Zhenwei Yi, Fangke Zhan, Yijia Chen, Ran Zhang, Haodong Lin, Liming Zhao
Summary: A water-soluble conductive material was synthesized by grafting polyaniline onto carboxymethyl chitosan, and dual cross-linked hydrogels with injectable, self-healing, and conductive properties were created. The hydrogel showed good biocompatibility, elastic modulus, and electrical conductivity, promoting the proliferation and migration of Schwann cells and enhancing nerve conduction velocity in sciatic nerve injury.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Biomedical
Shuhui Yang, Jinjin Zhu, Changfeng Lu, Yi Chai, Zheng Cao, Jiaju Lu, Zhe Zhang, He Zhao, Yin-Yuan Huang, Shenglian Yao, Xiangdong Kong, Peixun Zhang, Xiumei Wang
Summary: The AFG/fSAP hydrogel, with synergistic topographical and biochemical cues, successfully repaired a 15-mm peripheral nerve defect in rats through enhancing alignment and neurotrophin secretion. It showed satisfactory morphological and functional recovery, comparable to autografts, and activated regeneration-associated gene expression and signaling pathways.
BIOACTIVE MATERIALS
(2022)
Article
Health Care Sciences & Services
Arne Boecker, Martin Aman, Ulrich Kneser, Leila Harhaus, Frank Siemers, Felix Stang
Summary: The efficacy of chitosan-based nerve conduits in regenerating sensory nerves in the hand was evaluated in this study. The results showed that this type of nerve conduit had similar functional outcomes and patient satisfaction to autologous nerve grafts in treating small nerve defects.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Xin Quan, Liangliang Huang, Yafeng Yang, Teng Ma, Zhongyang Liu, Jun Ge, Jinghui Huang, Zhuojing Luo
NEUROCHEMICAL RESEARCH
(2017)
Article
Nanoscience & Nanotechnology
Zhongyang Liu, Shu Zhu, Liang Liu, Jun Ge, Liangliang Huang, Zhen Sun, Wen Zeng, Jinghui Huang, Zhuojing Luo
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2017)
Article
Cell & Tissue Engineering
Teng Ma, Lei Zhu, Yafeng Yang, Xin Quan, Liangliang Huang, Zhongyang Liu, Zhen Sun, Shu Zhu, Jinghui Huang, Zhuojing Luo
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2018)
Article
Neurosciences
Liangliang Huang, Bing Xia, Zhongyang Liu, Quanliang Cao, Jinghui Huang, Zhuojing Luo
FRONTIERS IN CELLULAR NEUROSCIENCE
(2017)
Article
Engineering, Biomedical
Lei Zhu, Kai Wang, Teng Ma, Liangliang Huang, Bing Xia, Shu Zhu, Yafeng Yang, Zhongyang Liu, Xin Quan, Kai Luo, Deling Kong, Jinghui Huang, Zhuojing Luo
ADVANCED HEALTHCARE MATERIALS
(2017)
Article
Clinical Neurology
Shu Zhu, Jun Ge, Zhongyang Liu, Liang Liu, Da Jing, Mingzi Ran, Meng Wang, Liangliang Huang, Yafeng Yang, Jinghui Huang, Zhuojing Luo
FRONTIERS IN NEUROLOGY
(2017)
Article
Engineering, Biomedical
Liangliang Huang, Lei Zhu, Xiaowei Shi, Bing Xia, Zhongyang Liu, Shu Zhu, Yafeng Yang, Teng Ma, Pengzhen Cheng, Kai Luo, Jinghui Huang, Zhuojing Luo
ACTA BIOMATERIALIA
(2018)
Article
Biochemistry & Molecular Biology
Liangliang Huang, Bing Xia, Xiaowei Shi, Jianbo Gao, Yujie Yang, Feng Xu, Fengyu Qi, Chao Liang, Jinghui Huang, Zhuojing Luo
Article
Nanoscience & Nanotechnology
Jianbo Gao, Bing Xia, Shengyou Li, Liangliang Huang, Teng Ma, Xiaowei Shi, Kai Luo, Yujie Yang, Laihe Zhao, Hao Zhang, Beier Luo, Jinghui Huang
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Neurosciences
Bing Xia, Jianbo Gao, Shengyou Li, Liangliang Huang, Teng Ma, Laihe Zhao, Yujie Yang, Jinghui Huang, Zhuojing Luo
FRONTIERS IN CELLULAR NEUROSCIENCE
(2019)
Article
Neurosciences
Jianhua Zhou, Shengyou Li, Jianbo Gao, Yawei Hu, Shaochu Chen, Xinle Luo, Hao Zhang, Zhuojing Luo, Jinghui Huang
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Article
Nanoscience & Nanotechnology
Liangliang Huang, Jianbo Gao, Heran Wang, Bing Xia, Yujie Yang, Feng Xu, Xiongfei Zheng, Jinghui Huang, Zhuojing Luo
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Clinical Neurology
Yu-Jie Yang, Xin Huang, Xiao-Ning Gao, Bing Xia, Jian-Bo Gao, Chen Wang, Xiao-Ling Zhu, Xiao-Juan Shi, Hui-Ren Tao, Zhuo-Jing Luo, Jing-Hui Huang
Summary: The study evaluated the impact and feasibility of an optimized ERAS pathway in surgically treated AIS patients. The ERAS pathway was found to improve perioperative outcomes by providing stronger analgesia, faster ambulation, and earlier discharge for AIS patients.
WORLD NEUROSURGERY
(2021)
Article
Multidisciplinary Sciences
Chang Liu, Jianbo Gao, Xinxin Cui, Zhipeng Li, Lei Chen, Yuan Yuan, Yaolei Zhang, Liangwei Mei, Lan Zhao, Dan Cai, Mingliang Hu, Botong Zhou, Zihe Li, Tao Qin, Huazhe Si, Guangyu Li, Zeshan Lin, Yicheng Xu, Chenglong Zhu, Yuan Yin, Chenzhou Zhang, Wenjie Xu, Qingjie Li, Kun Wang, M. Thomas P. Gilbert, Rasmus Heller, Wen Wang, Jinghui Huang, Qiang Qiu
Summary: The suite of adaptations associated with the extreme stature of giraffes is mainly related to cardiovascular, bone growth, vision, hearing, and circadian functions. The giraffe FGFRL1 gene plays a key role in resistance to hypertension and increased bone mineral density, contributing to giraffe's adaptations to their tall stature.
Article
Medicine, Research & Experimental
Bing Xia, Jianbo Gao, Shengyou Li, Liangliang Huang, Lei Zhu, Teng Ma, Laihe Zhao, Yujie Yang, Kai Luo, Xiaowei Shi, Liangwei Mei, Hao Zhang, Yi Zheng, Lei Lu, Zhuojing Luo, Jinghui Huang