Article
Biochemical Research Methods
Mckenna G. G. Hanson, Christian J. J. Grimme, Nicholas W. W. Kreofsky, Sidharth Panda, Theresa M. M. Reineke
Summary: Nucleic acid-based medicines and vaccines are playing an increasingly important role in our therapeutic toolbox. Antisense oligonucleotides (ASOs) are a key genetic medicine that can downregulate protein production. However, they need a delivery vehicle to enter cells. This study aimed to develop a method to rapidly discover new micelle formulations using mixed diblock polymers, which show improved delivery efficiency compared to linear nonmicelle variants.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Christian J. Grimme, Mckenna G. Hanson, Louis G. Corcoran, Theresa M. Reineke
Summary: This study examined the complexation and biological delivery of a short single-stranded antisense oligonucleotide (ASO) payload with four polymer derivatives. The results showed that micelleplexes, templated by the size and shape of unloaded micelles, are superior delivery vehicles for ASOs. DB micelleplexes promoted the largest gene silencing, internalization, and tolerable toxicity, while ObDB micelleplexes displayed enhanced colloidal stability and highly efficient payload trafficking despite having lower cellular uptake.
Article
Medicine, Research & Experimental
Daisuke Ono, Ken Asada, Daishi Yui, Fumika Sakaue, Kotaro Yoshioka, Tetsuya Nagata, Takanori Yokota
Summary: Research has shown that DNA/RNA heteroduplex oligonucleotide (HDO) has a different intracellular trafficking mechanism compared to the parental antisense oligonucleotide (ASO), resulting in gene silencing through separation, endosomal release, and nuclear transport. Early separation of HDO in early endosomes allows for the more efficient transport of the antisense strand (AS) to the nucleus, with time-locked events occurring within 30 seconds.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Chemistry, Multidisciplinary
Kannan Sugumar, Gopalsamy Vignesh, Sankaralingam Arunachalam
Summary: In this study, a series of ternary copper(II) complexes anchored branched polyethyleneimine (BPEI) were synthesized and their interactions with serum albumins were investigated. The binding affinities increased with the degree of anchoring, and copper(II) complexes closer to the BPEI chain showed electrostatic and hydrophobic interactions with the proteins.
Article
Chemistry, Multidisciplinary
Caroline O. Sarmento, Bruno F. A. Pinheiro, Josielle Abrahao, Otavio A. Chaves, Mariete B. Moreira, Sofia Nikolaou
Summary: This study found that the compound [Ru2O(keto)(2)(py)(6)](PF6)(2) interacts with both DNA and HSA, with a stronger interaction with HSA. The interaction occurs mainly through a static mechanism and is enthalpically driven. The molecular docking results also support these observations.
Article
Chemistry, Multidisciplinary
Marzieh Dadkhah Aseman, Parisa Negaresh, Zahra Shojaeifard, Bahram Hemmateenejad, S. Masoud Nabavizadeh
Summary: The biomolecular interactions between two previously reported cycloplatinated complexes and bovine serum albumin (BSA) were investigated. The results showed a strong binding interaction between the complexes and the protein with a static quenching mechanism. The binding was found to be exothermic, involving mainly noncovalent hydrophobic forces and ionic interactions. The complexes induced structural changes in the protein and exhibited cytotoxicity against various cancer cell lines.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Oncology
Zhihong Gong, Mary E. Platek, Cathee Till, Phyllis J. Goodman, Catherine M. Tangen, Elizabeth A. Platz, Marian L. Neuhouser, Ian M. Thompson, Regina M. Santella, Christine B. Ambrosone
Summary: The study of gene polymorphisms related to oxidative stress and DNA repair provides new insights into the genetic basis of prostate cancer. Researchers found associations between certain gene polymorphisms and prostate cancer risk, particularly in the group treated with finasteride. The associations may be influenced by intraprostatic sex hormone levels and antioxidant status.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Physical
Ribhu Maity, Nayim Sepay, Ushasi Pramanik, Kalyanmoy Jana, Saptarshi Mukherjee, Swapan Maity, Dasarath Mal, Tithi Maity, Bidhan Chandra Samanta
Summary: In this study, a copper(II) complex was synthesized and its structure and potential protein-binding properties were investigated. Experimental results confirmed the complex's strong binding ability to bovine serum albumin and its fluorescence-quenching effect, as well as its impact on the cell viability of cancer cells.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Article
Chemistry, Applied
Sidhali U. Parsekar, Paramita Haldar, P. K. Sudhadevi Antharjanam, Manjuri Kumar, Aditya P. Koley
Summary: A new dinuclear copper complex formed in solution and a tetranuclear compound in solid, exhibiting efficient DNA binding and anticancer activities. The complex showed strong binding affinity to human serum albumin and induced apoptosis in cancer cells.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Yiran Ying, Ke Fan, Sicong Zhu, Xin Luo, Haitao Huang
JOURNAL OF PHYSICAL CHEMISTRY C
(2020)
Article
Chemistry, Multidisciplinary
Zejun Li, Xiuying Zhang, Xiaoxu Zhao, Jing Li, Tun Seng Herng, Haomin Xu, Fanrong Lin, Pin Lyu, Xinnan Peng, Wei Yu, Xiao Hai, Cheng Chen, Huimin Yang, Jens Martin, Jing Lu, Xin Luo, A. H. Castro Neto, Stephen J. Pennycook, Jun Ding, Yuanping Feng, Jiong Lu
ADVANCED MATERIALS
(2020)
Article
Chemistry, Physical
Wanling Liang, Xin Luo
JOURNAL OF PHYSICAL CHEMISTRY C
(2020)
Review
Chemistry, Multidisciplinary
Yiran Ying, Xin Luo, Jinli Qiao, Haitao Huang
Summary: Double-atom catalysts (DACs) have emerged as a novel frontier in heterogeneous catalysis, showing improved catalytic activity through synergistic effects while maintaining high atomic utilization efficiency, good selectivity, and stability. Current research focuses on the design, experimental and theoretical progress, and practical applications of DACs in various catalytic reactions.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Engineering, Environmental
Yi Zeng, Xin Luo, Feng Li, Anhua Huang, Hongmei Wu, Guo Qin Xu, Song Ling Wang
Summary: The study developed FeOOH/Li0.1WO3 core-shell nanorods to enhance the efficiency of photocatalytic conversion of methane to methanol. The introduction of lithium ions and the FeOOH-based Fenton-like reaction increased the generation of (OH)· radicals, leading to efficient formation of CH4OH under visible and near-infrared light.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Weiwei Xing, Qianqian Yao, Wenpeng Zhu, He Jiang, Xiaoyue Zhang, Ye Ji, Jian Shao, Weiming Xiong, Biao Wang, Bangmin Zhang, Xin Luo, Yue Zheng
Summary: This study developed compact films of all-inorganic halide perovskites (AIHPs) by replacing organic groups with Cs, which can adsorb oxygen at grain boundaries in dark with high sensitivity and stability. The experiments and modeling revealed the donor-acceptor competition via halide vacancy filling, leading to the modulation of carrier concentration and mobility. These findings provide insights into oxygen sensing by perovskite materials and lay the foundation for further optimization of AIHPs as promising oxygen sensors.
Article
Multidisciplinary Sciences
Chao Xu, Jianfeng Mao, Xuyun Guo, Shanru Yan, Yancong Chen, Tsz Wing Lo, Changsheng Chen, Dangyuan Lei, Xin Luo, Jianhua Hao, Changxi Zheng, Ye Zhu
Summary: The authors experimentally demonstrate 2D ferroelasticity in both exfoliated and CVD-grown beta'-In2Se3 down to few-layer thickness using atomic-resolution electron microscopy, in situ X-ray diffraction, and polarized-light microscopy, providing tantalizing potential to tune 2D functionalities through strain or domain wall engineering.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Applied
Xing Yang Wu, Zhiyuan Tang, Xiaoxu Zhao, Xin Luo, Stephen John Pennycook, Song Ling Wang
Summary: The combination of gold as co-catalyst and singlet oxygen as oxidant is an effective strategy for selectively converting methane. Atomically dispersed Au on WO3 showed enhanced visible light photocatalytic conversion of CH4, with a high selectivity. Investigation of the radicals-pathway mechanism of methane coupling and theoretical calculations on the electronic structure of Au/WO3 were conducted for a better understanding of the process.
JOURNAL OF ENERGY CHEMISTRY
(2021)
Article
Chemistry, Physical
Yi Zeng, Zhiyuan Tang, Xingyang Wu, Anhua Huang, Xin Luo, Guo Qin Xu, Yongfa Zhu, Song Ling Wang
Summary: This study presents an atomically dispersed gold on tungsten trioxide catalyst for photocatalytic oxidation of methane to methanol. Experimental and theoretical results indicate that the tip-enhanced effect enhances the catalytic activity of methane oxidation, and the lower adsorption energy of methanol on Au1 suppresses overoxidation and promotes selectivity.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2022)
Article
Chemistry, Physical
Ke Fan, Yiran Ying, Xin Luo, Haitao Huang
Summary: The surface-functionalized V2N MXenes are proposed as host materials to enhance the electrochemical performance of Li-S batteries, improving the kinetics and suppressing the shuttling of lithium polysulfides. Theoretical calculations show that V2NS2 exhibits the lowest energy barrier for sulfur reduction reaction during discharge, while also displaying outstanding catalytic ability for Li2S decomposition during charge, suggesting its potential as a promising host material for S cathodes.
JOURNAL OF MATERIALS CHEMISTRY A
(2021)
Article
Materials Science, Multidisciplinary
Yancong Chen, Zhiyuan Tang, Huili Shan, Bin Jiang, Yulong Ding, Xin Luo, Yue Zheng
Summary: In this study, a strategy to enhance the out-of-plane piezoelectric coefficients by constructing In2Se3/transition metal dichalcogenides (TMDs) heterostructures was proposed. The strategy showed great piezoelectric enhancement compared with monolayer In2Se3, with the largest e(31) of 2.9x10(-10) C/m achieved in MoS2/In2Se3. A phenomenological model was constructed to connect the piezoelectric coefficients with the polarizations of the heterostructures, and the induced dipole moment strongly affected the band structure of heterostructures, yielding tunable light absorption. The proposed In2Se3/TMDs heterostructures represent an innovative strategy for the development of future efficient piezoelectric materials.
Article
Chemistry, Physical
Yiran Ying, Ke Fan, Xin Luo, Jinli Qiao, Haitao Huang
Summary: This study showcases the promising bifunctional OER/ORR catalytic performance of single-atom catalysts supported on the C2N monolayer, with Rh@C2N, Au, and Pd@C2N demonstrating superior activity. The origin of this catalytic activity is revealed through DFT calculations and ML modelling, shedding light on the underlying mechanisms and element-specific activity.
JOURNAL OF MATERIALS CHEMISTRY A
(2021)
Article
Nanoscience & Nanotechnology
Shuoguo Yuan, Weng Fu Io, Jianfeng Mao, Yancong Chen, Xin Luo, Jianhua Hao
ACS APPLIED NANO MATERIALS
(2020)
Article
Chemistry, Physical
Ke Fan, Yiran Ying, Xin Luo, Haitao Huang
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2020)
Article
Chemistry, Physical
Yanqing Zhang, Weiming Xiong, Weijin Chen, Xin Luo, Xiaoyue Zhang, Yue Zheng
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2020)