Article
Orthopedics
Shuhei Otsuki, Shunsuke Sezaki, Yoshinori Okamoto, Takashi Ishitani, Hitoshi Wakama, Masashi Neo
Summary: This study evaluated the safety and efficacy of a novel meniscal scaffold for the treatment of irreparable meniscal injuries. The results showed that the scaffold could tolerate shear forces and had therapeutic potentials for irreparable meniscal tears in humans.
Article
Engineering, Biomedical
Kuniaki Ikeda, Shuhei Otsuki, Nobuhiro Okuno, Shunsuke Sezaki, Kosuke Nakagawa, Yuki Miyamoto, Yoshinori Okamoto, Hitoshi Wakama, Tomohiro Okayoshi, Masashi Neo
Summary: The novel two-layer meniscal sheet scaffold showed good biomechanical strength and healing effects in a rabbit meniscal defect model, promoting surrounding tissue regeneration.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Zahra Abpeikar, Moosa Javdani, Seyed Abbas Mirzaei, Akram Alizadeh, Lida Moradi, Mostafa Soleimannejad, Shahin Bonakdar, Shiva Asadpour
Summary: A hybrid scaffold with surface modified by gelatin, chitosan, and hyaluronic acid biomacromolecules was developed and evaluated for meniscus regeneration. The scaffolds showed enhanced swelling and degradation rate, properties close to native meniscus tissue, and successful promotion of chondrocyte marker genes expression. The animal study demonstrated significant regeneration after treatment with adipose-derived mesenchymal stem cells-loaded scaffold.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
R. Kevin Tindell, Michael J. McPhail, Cheryl E. Myers, Juergen Neubauer, Justin M. Hintze, David G. Lott, Julianne L. Holloway
Summary: This study presents a trilayered, partially degradable hydrogel scaffold that mimics the multilayered structure of the vocal fold lamina propria. The scaffold promotes cell viability, cell spreading, and vibration with air flow, and successfully produces sound in proof-of-concept air flow studies. This work represents a critical first step in designing a multilayered hydrogel scaffold for vocal fold tissue engineering.
Article
Biochemistry & Molecular Biology
Yongchao Jiang, Haonan Wang, Xiaofeng Wang, Qian Li
Summary: A functional coating based on hyaluronic acid, dopamine, and heparin was developed to promote endothelialization and resist thrombus. The coating enhanced the surface hydrophilicity and mechanical properties of the scaffold, promoted EC proliferation and angiogenesis, and effectively inhibited platelet adhesion and blood clotting.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Green & Sustainable Science & Technology
Pei Feng, Saipu Shen, Yang Shuai, Shuping Peng, Cijun Shuai, Shijie Chen
Summary: In this study, PLLA chains were grafted onto graphene oxide (GO) to improve the interfacial interaction for PLLA/PGA scaffold. The PLLA-grafted GO reduced the interfacial tension and increased the contact surface area between PLLA and PGA, enhancing the interfacial interaction. The PLLA/PGA scaffold containing 1 wt% the PLLA-grafted GO showed significant improvement in tensile and compressive strength, and demonstrated good cytocompatibility for cell adhesion, migration, and proliferation.
SUSTAINABLE MATERIALS AND TECHNOLOGIES
(2023)
Article
Biochemistry & Molecular Biology
Hyeseon Lee, Sijoon Lee, Keum-Yong Seong, Subin Kang, Min-Soo Seo, Su Ryon Shin, Kyoung Hyup Nam, Seung Yun Yang
Summary: This study introduces a dural sealant using light-activated hyaluronic acid that provides fast sealing performance and high biocompatibility. The sealant demonstrated faster sealing and enhanced dural repair with accelerated bone formation in an animal model, without any adverse reactions.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Orthopedics
Luisa de Roy, Kerstin Eichhorn, Martin Faschingbauer, Klaus Schlickenrieder, Anita Ignatius, Andreas Martin Seitz
Summary: The purpose of this in vitro study was to investigate the effect of hyaluronic acid supplementation on knee joint friction during osteoarthritis progression. The results showed that knee joint friction does not increase with degeneration, and hyaluronic acid supplementation does not lead to an initial decrease in friction.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Engineering, Biomedical
Suk Young Hong, Tuong Van Thi Tran, Hoe Jin Kang, Garima Tripathi, Byong Taek Lee, Sang Ho Bae
Summary: The study focused on incorporating BCP nanoparticles into modified HA-based injectable hydrogels for bone tissue engineering. Results showed that 3% (w/v) HA-HS hydrogel exhibited suitable properties for an injectable hydrogel system for bone tissue engineering. In vitro tests demonstrated that the BCP-loaded modified hydrogels were biocompatible with osteoblast cells.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Article
Materials Science, Multidisciplinary
Xiaofeng Chen, Chaoyin Jiang, Ting Wang, Tonghe Zhu, Xiaolin Li, Jinghuan Huang
Summary: This study designed and developed biphasic osteochondral scaffolds with layer-specific differentiation, achieving simultaneous integrated regeneration of articular cartilage and subchondral bone by manipulating the physicochemical properties and biological properties of the materials.
MATERIALS & DESIGN
(2022)
Article
Biochemistry & Molecular Biology
Hou Liu, Yubin Feng, Songtian Che, Lin Guan, Xinting Yang, Yue Zhao, Linan Fang, Andrei V. Zvyagin, Quan Lin
Summary: This study explored a method of promoting spinal cord injury repair by injecting neural stem cells into the injury site using a biodegradable conductive hydrogel scaffold. Results showed that the conductive hydrogel facilitated the differentiation of stem cells into neurons and inhibited the formation of glial cells and scars. The study provides a new approach for treating spinal cord injuries.
Article
Engineering, Multidisciplinary
Qiusheng Wang, Shuiqing Zhou, Lu Wang, Renchuan You, Shuqin Yan, Qiang Zhang, Mingzhong Li
Summary: This study presents a novel bioactive scaffold designed with biomimetic technology by mimicking the chemical components and biophysical nanostructures of extracellular matrix. The scaffold showed better cytocompatibility to support cell spread, proliferation and differentiation. In vivo experiments demonstrated that the scaffold with nanofibers as a template not only accelerated wound healing but also regulated collagen arrangement to inhibit scar formation.
COMPOSITES PART B-ENGINEERING
(2021)
Article
Engineering, Biomedical
Boao Xia, Dong-Hwa Kim, Sonia Bansal, Yongho Bae, Robert L. Mauck, Su-Jin Heo
Summary: A new fibrous scaffold system was developed to support and enhance meniscus cell function and matrix production, providing a new therapeutic strategy for substitute or replace injured meniscus tissue.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
Yunqing Yue, Peihu Xu, Zhixin Lei, Kebi Li, Jingyi Xu, Jing Wen, Sining Wang, Wanting Cheng, Sihui Lin, Zhijun Huang, Haixing Xu
Summary: In this study, a bi-layer scaffold was designed and fabricated using drug-dispersed gelatin methacrylate (GELMA) hydrogel and drug-encapsulated coaxial fiber scaffold made from silk fiber (SF) and polylactic acid (PLA). This scaffold showed promising properties for cartilage tissue engineering, including suitable porosity, pore size, mechanical strength, and excellent drug release properties.
Article
Biochemistry & Molecular Biology
Shrikant Sitaram Kirwale, Swati Sharma, Aniruddha Roy
Summary: Current cell grafting techniques primarily rely on seeding cells on pre-formed scaffolds, which do not mimic the tissue's 3D architecture. This study evaluated a strategy based on poly-electrolyte complexation for 3D engraftment of cells in a porous polymeric scaffold. The results demonstrated that the in-situ forming PEC of CH, CS, and HA had good physicochemical properties for cell grafting and supported grafted cells with improved function.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)