Journal
ACTA BIOMATERIALIA
Volume 7, Issue 6, Pages 2726-2732Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2011.02.020
Keywords
Osseointegration; Titania nanofibers; Laser ablation; Surface modification; Three-dimensional nanostructure
Funding
- Natural Science and Engineering Research Council of Canada
Ask authors/readers for more resources
The primary objective of current tissue regeneration research is to synthesize nano-based platforms that can induce guided, controlled, and rapid healing. Titanium nanotubes have been extensively considered as a new biomaterial for biosensors, implants, cell growth, tissue engineering, and drug delivery systems. However, due to their one-dimensional structure and chemical inertness, cell adhesion to nanotubes is poor. Therefore, further surface modification is required to enhance nanotube-cell interaction. Although there have been a considerable number of studies on growing titanium nanotubes, synthesizing a three-dimensional (3-D) nano-architecture which can act as a growth support platform for bone and stem cells has not been reported so far. Therefore, we present a novel technique to synthesize and grow 3-D titania interwoven nanofibrous structures on a titanium substrate using femtosecond laser irradiation under ambient conditions. This surface architecture incorporate the functions of 3-D nano-scaled topography and modified chemical properties to improve osseointegration while at the same time leaving space to deliver other functional agents. The results indicate that laser pulse repetition can control the density and pore size of engineered nanofibrous structures. In vitro experiments reveal that the titania nanofibrous architecture possesses excellent bioactivity and can induce rapid, uniform, and controllable bone-like apatite precipitation once immersed in simulated body fluid (SBF). This approach to synthesizing 3-D titania nanofibrous structures suggests considerable promise for the promotion of Ti interfacial properties to develop new functional biomaterials for various biomedical applications. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available