Article
Engineering, Biomedical
Itsuki Oizumi, Ryo Hamai, Yukari Shiwaku, Yu Mori, Takahisa Anada, Kazuyoshi Baba, Naohisa Miyatake, Soshi Hamada, Kaori Tsuchiya, Shin-Nosuke Nishimura, Eiji Itoi, Osamu Suzuki
Summary: This study investigated the effect of the simultaneous hydrolysis of octacalcium phosphate (OCP) and poly (lactic-co-glycolic acid) (PLGA) on osteoconductivity. Increasing OCP dose was found to lead to higher weight loss of PLGA and lower glass transition temperature of PLGAs. OCP/PLGA composites demonstrated enhanced bone formation and regenerative capacity in femoral defects.
ACTA BIOMATERIALIA
(2021)
Review
Engineering, Biomedical
Ilijana Kovrlija, Janis Locs, Dagnija Loca
Summary: Octacalcium phosphate (OCP) has significant advantages as a precursor to biologically formed apatite and is utilized as a carrier for biologically active substances in bone regeneration. However, research on drug delivery systems with OCP is still in its pioneering stage, and comprehensive data is lacking to fully understand the benefits it can bring. Further studies are needed to explore the potential of OCP in drug delivery systems for bone tissue engineering.
ACTA BIOMATERIALIA
(2021)
Review
Engineering, Biomedical
Osamu Suzuki, Ryo Hamai, Susumu Sakai
Summary: Octacalcium phosphate (OCP), as a precursor of bone apatite crystals, exhibits highly osteoconductive properties and activates bone tissue-related cells, promoting bone formation. The conversion of OCP increases its stimulatory capacity by hydrolysis toward Ca-deficient hydroxyapatite, resulting in increased surface area and adsorption affinity. Introducing structural defects through co-precipitation with gelatin controls the dissolution rate, enhancing material biodegradation and osteogenecity. Controlling the biodegradation rate is crucial for optimizing the osteogenecity of OCP materials.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Joo-Seong Kim, Tae-Sik Jang, Suk-Young Kim, Won-Pyo Lee
Summary: This study evaluated the effect of a commercialized octacalcium phosphate (OCP)-based synthetic bone substitute material (Bontree(R)) in vitro, in vivo, and in clinical cases. Bontree(R) suppressed RANKL and increased ALP activity, showing a high new bone formation ability. Clinical application demonstrated a 100% success rate for ridge or sinus augmentation using Bontree(R).
APPLIED SCIENCES-BASEL
(2021)
Article
Materials Science, Ceramics
Antonia Ressler, Irena Ivanisevic, Andreja Zuzic, Nicolas Somers
Summary: Octacalcium phosphate shows promising properties for bone tissue regeneration, but hydroxyapatite is still considered the most promising material. Many studies confirm the superior performance of octacalcium phosphate in vivo.
CERAMICS INTERNATIONAL
(2022)
Article
Orthopedics
Cheol-Hee Jeong, Jooseong Kim, Hyun Sil Kim, Song-Yi Lim, Dawool Han, Aaron J. Huser, Sang Bae Lee, Yeonji Gim, Jeong Hyun Ji, Dohun Kim, Amaal M. Aldosari, Kyelim Yun, Yoon Hae Kwak
Summary: In this study, three types of OCPs were compared to commercially available 8-TCP for their potential to promote bone formation in rat tibias with defects. The results showed that OCP/Alg was equivalent to 8-TCP in promoting bone bridge formation and had better biodegradability. OCP/Col accelerated bone formation in defect repair.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Biochemistry & Molecular Biology
Anastasia Yu. Teterina, Igor V. Smirnov, Irina S. Fadeeva, Roman S. Fadeev, Polina V. Smirnova, Vladislav V. Minaychev, Margarita I. Kobyakova, Aleksandr Yu. Fedotov, Sergey M. Barinov, Vladimir S. Komlev
Summary: The study presented the synthesis of low-temperature calcium phosphate compounds with strontium substitution to improve bioactive properties, indicating the effectiveness of using strontium in OCP for enhancing biocompatibility in composite materials intended for bone repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Seok-Jun Kim, Joo-Seong Kim, Woong Kim, Suk-Young Kim, Won-Pyo Lee
Summary: This study evaluated the efficacy of using Bontree (R) for LSFE through radiographic and histomorphometric analysis. The results showed that Bontree (R) is effective in promoting new bone formation.
Article
Engineering, Biomedical
Julia Gao, Yingchao Su, Yi-Xian Qin
Summary: This study compared the in vitro and in vivo degradation and biocompatibility behaviors of magnesium alloys with calcium phosphate coatings, showing that the CaP coating significantly improved biodegradation behavior and biocompatibility of the Mg alloy. In vitro tests were found to be a quick screening tool for biodegradation rate, with the in vivo degradation rate being slower than in vitro immersion degradation rate.
BIOACTIVE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Hongzhou Shen, Yu Zhuang, Chenglong Zhang, Changru Zhang, Yuan Yuan, Hongbo Yu, Jiawen Si, Guofang Shen
Summary: This study investigated the value of applying BMP2-loaded calcium phosphate cement in restoring large-scale alveolar bone defects. The results showed that BMP2-CPC can induce favorable bone regeneration and remodeling, accompanied by active osteoclast formation and optimized biomaterial resorption. Osteoclasts played a multifaceted role in the bone regeneration process by promoting osteogenic differentiation and biomaterial remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Joao Cardeira-da-Silva, Anabela Bensimon-Brito, Marco Tarasco, Ana S. Brandao, Joana T. Rosa, Jorge Borbinha, Paulo J. Almeida, Antonio Jacinto, M. Leonor Cancela, Paulo J. Gavaia, Didier Y. R. Stainier, Vincent Laize
Summary: By studying the bone patterning during zebrafish fin ray regeneration, it was discovered that the fin rays form through two mineralization fronts and bifurcation is not a simple splitting process. Osteolytic tubules play a key role in defining the position of the branchpoint.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Medicine, General & Internal
Yu Mori, Ryo Hamai, Toshimi Aizawa, Osamu Suzuki
Summary: Bone grafting is commonly used in clinical settings to treat bone defects. The development of bone graft substitutes, such as Octacalcium phosphate (OCP), has shown promise in achieving superior bone formation ability compared to autogenous bone grafting. OCP can be used in composite forms with natural polymers like collagen and gelatin to enhance its usability and osteogenic potential. This review discusses the development and preclinical results of OCP and OCP/gelatin (OCP/Gel) composites, and the potential future applications in orthopedics.
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Chemistry, Physical
Jooseong Kim, Sukyoung Kim, Inhwan Song
Summary: This study compared the bone regeneration capacity of OCP products with two commonly used materials and found that OCP showed significantly higher resorption and new bone formation. OCP bone substitutes can enhance bone regeneration significantly by activating osteoblasts and a rapid phase transition of OCP crystals to biological apatite crystals (mineralization), as well as providing additional space for new bone formation by rapid resorption.
Article
Materials Science, Multidisciplinary
Hisashi Ozaki, Ryo Hamai, Yukari Shiwaku, Susumu Sakai, Kaori Tsuchiya, Osamu Suzuki
Summary: The study found that mixing octacalcium phosphate (OCP) with autologous bone has a positive effect on bone regeneration, promoting cellular ALP activity and inducing bone formation and osteoclastic resorption reactions. Additionally, structural and tissue changes were observed on the materials used.
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Jiwen Chen, Huajun Wang, Yunjun Wu, Youjie Liu, Yiwan Shi, Changshun Chen, Huige Hou, Zhengang Zha, Xiaofei Zheng, Tingting Wu
Summary: A novel scaffold material with good mechanical and biocompatible properties was fabricated in this study. It can promote proliferation and osteogenic differentiation of bone cells, making it a promising biomaterial for the treatment of bone defects.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Biology
Mamoru Ueda, Yoshiya Hashimoto, Yoshitomo Honda, Shunsuke Baba, Shosuke Morita
MEDICAL MOLECULAR MORPHOLOGY
(2019)
Article
Polymer Science
Masahiko Minoda, Tomomi Otsubo, Yohei Yamamoto, Jianxin Zhao, Yoshitomo Honda, Tomonari Tanaka, Jin Motoyanagi
Article
Multidisciplinary Sciences
Wen Liao, Yoshiya Hashimoto, Yoshitomo Honda, Peiqi Li, Yang Yao, Zhihe Zhao, Naovuki Matsumoto
Article
Biochemistry & Molecular Biology
Anqi Huang, Yoshitomo Honda, Peiqi Li, Tomonari Tanaka, Shunsuke Baba
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Chemistry, Physical
Jianxin Zhao, Yoshitomo Honda, Tomonari Tanaka, Yoshiya Hashimoto, Naoyuki Matsumoto
Article
Biochemistry & Molecular Biology
Yoshitomo Honda, Anqi Huang, Tomonari Tanaka, Xiaoyu Han, Beiyuan Gao, Haitao Liu, Xinchen Wang, Jianxin Zhao, Yoshiya Hashimoto, Kazuyo Yamamoto, Naoyuki Matsumoto, Shunsuke Baba, Makoto Umeda
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Chemistry, Physical
Xiaoyu Han, Yoshitomo Honda, Tomonari Tanaka, Kazuki Imura, Yoshiya Hashimoto, Kazushi Yoshikawa, Kazuyo Yamamoto
Article
Biochemistry & Molecular Biology
Jinzhao Lyu, Yoshiya Hashimoto, Yoshitomo Honda, Naoyuki Matsumoto
Summary: Scaffolds play a crucial role in bone defect repair by stimulating cell proliferation and differentiation. The study found that using CellSaic containing rDPSCs showed better outcomes for promoting bone regeneration compared to using rBMSCs, indicating DPSCs as a promising source for bone tissue regenerative therapy, particularly in craniofacial bone defect repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xinchen Wang, Yoshitomo Honda, Jianxin Zhao, Hidetoshi Morikuni, Aki Nishiura, Yoshiya Hashimoto, Naoyuki Matsumoto
Summary: The study demonstrates that beta-TCP granules can induce senescent-like cells, and the administration of senolytics may improve bone-forming ability by inhibiting senescence-associated mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yanan Gong, Yoshitomo Honda, Tetsuya Adachi, Elia Marin, Kazushi Yoshikawa, Giuseppe Pezzotti, Kazuyo Yamamoto
Summary: The study investigated the effect of different types of Si3N4 granules on rat dental pulp cells and found that sintered Si3N4 granules significantly promoted cell attachment, upregulated odontogenic marker genes, and enhanced mineralization nodule formation. The sintering process positively altered the surface properties of Si3N4 granules and facilitated odontogenic differentiation, suggesting potential clinical applications in dentistry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Beiyuan Gao, Yoshitomo Honda, Yoichi Yamada, Tomonari Tanaka, Yoshihiro Takeda, Takayuki Nambu, Shunsuke Baba
Summary: The newly developed material vhEc-GS-beta showed high stability and bone-forming ability in experiments, achieved through thermal cross-linking induced in gelatin sponges by vacuum heating treatment. This insight could potentially lead to the development of novel materials with good operability and bone-forming ability in bone regenerative medicine.
Article
Chemistry, Multidisciplinary
Nobuhito Tsumano, Hirohito Kubo, Rie Imataki, Yoshitomo Honda, Yoshiya Hashimoto, Masahiro Nakajima
Summary: The study demonstrated that a composite gelatin sponge of alpha-tricalcium phosphate mixed with gelatin scaffolds induced bone regeneration in a rat calvarial defect model, with the group containing DFAT cells showing better results.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Physical
Kosuke Nakano, Hirohito Kubo, Masahiro Nakajima, Yoshitomo Honda, Yoshiya Hashimoto
Article
Polymer Science
Tomonari Tanaka, Keita Nakashima, Sotaro Tsuji, Xiaoyu Han, Jianxin Zhao, Yoshitomo Honda, Keiko Sakakibara, Yuuki Kurebayashi, Tadanobu Takahashi, Takashi Suzuki
Article
Cell & Tissue Engineering
Masanori Hashimoto, Yoshitomo Honda
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
(2019)