Review
Biochemistry & Molecular Biology
Joana R. Guedes, Pedro A. Ferreira, Jessica M. Costa, Ana L. Cardoso, Joao Peca
Summary: Microglia are tissue-resident macrophages that play roles in surveillance, neuronal support, and immune defense in the brain. They participate in engulfing neuronal precursors, modulating synaptic signaling, and shaping synaptic plasticity. Microglia in different brain regions exhibit distinct characteristics that may potentially contribute to the maturation and function of specific neuronal circuits.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Cell Biology
Manuela D. Mitsogiannis, Anna Pancho, Tania Aerts, Sonja M. Sachse, Ria Vanlaer, Lut Noterdaeme, Dietmar Schmucker, Eve Seuntjens
Summary: DSCAMs are involved in various neurodevelopmental processes, and their malfunction can lead to disorders such as Fragile X syndrome, intellectual disability, autism, and bipolar disorder. While Dscam and Dscaml1 knockout did not significantly affect developmental events in mice, gain of function experiments showed negative impacts on neural migration processes important for cortical development. This highlights the importance of genes encoding adhesive cues in neuronal migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Moushumi R. Dey, Kirthan Reddy, Hiroichi Yoshida, Naoko Nishiyama, Boris Zemelman, Hiroshi Nishiyama
Summary: The migration of neurons during brain development is a crucial process, and the presence of ectopic neurons in the molecular layer challenges the traditional view. This study reveals that the ectopic granule cells in the cerebellar cortex, known as mGCs, are as prevalent as other types of cells and exhibit similar functional properties to regular granule cells.
Article
Neurosciences
Ken-ichi Dewa, Nariko Arimura
Summary: Astrocytes have complex morphologies that allow them to interact with other astrocytes, blood vessels, and neurons. Adhesion molecules expressed by astrocytes play a vital role in regulating these interactions. Studies have shown the importance of adhesion molecules, such as neuron-glia cell adhesion molecules, astrotactins, and protocadherins, in forming and maintaining functional neural circuits. This review provides an overview and perspective on astrocyte-neuron contacts mediated by adhesion molecules, with a focus on cerebellar development. It also highlights a novel mechanism of interaction between neurons and astrocytes in tripartite synapses recently discovered by the authors.
NEUROSCIENCE RESEARCH
(2023)
Article
Neurosciences
Yutaro Komuro, Ludovic Galas, Yury M. Morozov, Jennifer K. Fahrion, Emilie Raoult, Alexis Lebon, Amanda K. Tilot, Shin Kikuchi, Nobuhiko Ohno, David Vaudry, Pasko Rakic, Hitoshi Komuro
Summary: The study reveals that galanin plays a role in accelerating neuronal cell migration during normal brain development by altering signaling pathways, and its levels are affected by brain injury which in turn influences granule cell migration. This suggests that manipulating galanin signaling could be a potential therapeutic target for acute brain injuries during development.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Inmaculada Crespo, Jaime Pignatelli, Veena Kinare, Hector R. Mendez-Gomez, Miriam Esgleas, Maria Jose Roman, Josep M. Canals, Shubha Tole, Carlos Vicario
Summary: This study investigates the impact of misexpression of the Tbr1 transcription factor on mouse neural progenitor cells. The results suggest that Tbr1 misexpression delays or disrupts neuronal migration, specification, and dendrite development, potentially leading to brain malformations.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Vasiliki Tellios, Matthew J. E. Maksoud, Wei-Yang Lu
Summary: This study is the first to characterize BG morphology and GLAST expression during development in nNOS(-/-) mice using immunohistochemistry and western blotting. The results showed that BG in nNOS(-/-) mice exhibited abnormal morphology and decreased GLAST expression compared with wildtype (WT) mice across postnatal development. It was also found that nNOS/NO signaling regulates BG development through a PKG-mediated mechanism.
Article
Biochemistry & Molecular Biology
Oded Mayseless, Gal Shapira, El Yazid Rachad, Andre Fiala, Oren Schuldiner
Summary: In this study, the role of neuronal activity in the developmental axon pruning of y-Kenyon cells in Drosophila mushroom body was examined. It was found that silencing neuronal activity is necessary for y-KC pruning, and this is achieved through the expression of the inward rectifying potassium channel 1 (irk1) and inhibition by APL neuron activity via GABA-B-R1 signaling.
Article
Genetics & Heredity
Seiya Yamada, Tomoya Mizukoshi, Akinori Tokunaga, Shin-Ichi Sakakibara
Summary: Our study reveals that the Inka2 gene serves as an endogenous Pak4 inhibitor in neurons, playing a critical role in synaptic formation.
Article
Biochemistry & Molecular Biology
Amin Esmaeilniakooshkghazi, Eric Pham, Sudeep P. George, Afzal Ahrorov, Fabian R. Villagomez, Michael Byington, Srijita Mukhopadhyay, Srinivas Patnaik, Jacinta C. Conrad, Monali Naik, Saathvika Ravi, Niall Tebbutt, Jennifer Mooi, Camilla M. Reehorst, John M. Mariadason, Seema Khurana
Summary: This study investigates the molecular mechanism of adherens junction (AJ) remodeling in colon cancer cells and the function of fascin1 in AJ remodeling. The researchers discovered that fascin1 renders AJs less stable but more dynamic by remodeling junctional actin and actomyosin contractility, which drives cell migration and mechanosensitive WNT/beta-catenin signaling activation. These findings highlight the role of AJ remodeling and mechanosensitive WNT/beta-catenin signaling in the growth and dissemination of colorectal carcinomas.
Article
Biochemistry & Molecular Biology
Guodong Chen, Lin Han, Senwei Tan, Xiangbin Jia, Huidan Wu, Yingting Quan, Qiumeng Zhang, Bin Yu, Zhengmao Hu, Kun Xia, Hui Guo
Summary: This study investigates the role of the KMT5B gene in neurodevelopmental disorders, including autism spectrum disorder (ASD), and reveals its essential functions in neuronal development, prenatal neurogenesis, and neuronal migration.
JOURNAL OF GENETICS AND GENOMICS
(2022)
Article
Multidisciplinary Sciences
Dahong Chen, Catherine E. McManus, Behram Radmanesh, Leah H. Matzat, Elissa P. Lei
Summary: The study suggests that the Drosophila chromatin insulator antagonist Shep represses gene expression during neuronal maturation by preventing E-P looping. Through chromatin conformation capture and reporter assays, two enhancer regions were identified to increase in looping frequency with the brat promoter specifically in pupal brains after Shep depletion, indicating temporal regulation of chromatin looping and enhancer accessibility during neuronal maturation.
NATURE COMMUNICATIONS
(2021)
Review
Cell Biology
Julie Stoufflet, Isabelle Caille
Summary: The primary cilium plays an important role in regulating cell motility, especially in neuronal migration, by controlling the rhythm and speed of migration.
Article
Multidisciplinary Sciences
Isreal Moreno, Irene Rodriguez-Sanchez, Xenia Schafer, Joshua Munger
Summary: HCMV infection induces the expression of a tissue atypical neuronal glycolytic enzyme, activating glycolysis and UDP-sugar metabolism, increasing the accumulation of glycosyl building blocks, and enabling the expression of an essential viral glycoprotein and the production of infectious virions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Sinan Sen, Ralf Erber
Summary: During orthodontic tooth movement, neuronal guidance molecules (NGMs), particularly Semaphorins, ephrins, and Eph receptors, have been identified to play important roles in bone remodeling. However, research on the functions of NGMs during orthodontic tooth movement is currently limited, and further studies are needed to fully understand their significance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Developmental Biology
J Víg, J Takács, H Abrahám, GG Kovács, J Hámori
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2005)
Article
Anatomy & Morphology
C Vastagh, J Vig, J Hámori, J Takács
ANATOMY AND EMBRYOLOGY
(2005)
Article
Developmental Biology
C Vastagh, J Víg, J Takács, J Hámori
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2005)
Article
Cell Biology
J Víg, J Takács, C Vastagh, Z Baldauf, E Veisenberger, J Hámori
JOURNAL OF NEUROCYTOLOGY
(2003)
Article
Neurosciences
J Takács, ZA Borostyánkoi, E Veisenberger, C Vastagh, J Víg, TJ Görcs, J Hámori
JOURNAL OF NEUROSCIENCE RESEARCH
(2000)
Article
Neurosciences
J Vig, D Goldowitz, DA Steindler, LM Eisenman