Journal
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
Volume 46, Issue 5, Pages 387-393Publisher
OXFORD UNIV PRESS
DOI: 10.1093/abbs/gmu018
Keywords
second mitochondria-derived activator of caspase; non-small-cell lung cancer; invasive ability; apoptosis; cloning ability; chemosensitivity
Categories
Funding
- Science and Technology research - projects of Ministry of Education of China [20110131120062]
Ask authors/readers for more resources
A series of structurally unique second mitochondria-derived activator of caspases (Smacs) that act as antagonists of the inhibitor of apoptosis proteins (IAPs) directly have been discovered. They play crucial roles in mitochondrial apoptosis pathways and promote chemotherapy-induced apoptosis. In this study, we constructed a eukaryotic expression vector pcDNA3.1/Smac and transfected it into A549 human lung cancer cells. Then we analyzed the cell invasive and cloning ability, as well as cell apoptosis induced by Taxol. The results showed that over-expressed Smac significantly inhibited A549 cell invasive and cloning ability and promoted apoptosis following Taxol treatment. This finding provides a potential approach for the biological therapy of lung cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available