Journal
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
Volume 45, Issue 2, Pages 71-79Publisher
OXFORD UNIV PRESS
DOI: 10.1093/abbs/gms084
Keywords
Wnt; -catenin signaling; Hippo signaling; cancer; tissue repair
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Traditionally, signaling pathways have been perceived to act in an autonomous manner to regulate tissue morphology, size, differentiation, and development. Recent evidence suggests that these pathways often intersect and regulate one another to elicit an appropriate response to a complex set of stimuli. Two pathways known to be important for development, growth, and homeostasis are the Wnt/-catenin and the Hippo/YAP pathways. Growing data indicate that these two pathways influence each other in a number of ways to properly regulate tissue growth and repair. Deregulation of these pathways often contributes to tumorigenesis. In this review, we will discuss the points of intersection between the Wnt/-catenin and Hippo/YAP pathways and how these interactions contribute to homeostasis, organ repair, and tumorigenesis.
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