Histone acetyltransferases and deacetylases: molecular and clinical implications to gastrointestinal carcinogenesis: Figure 1

The Dual EGFR/HER2 Inhibitor Lapatinib Synergistically Enhances the Antitumor Activity of the Histone Deacetylase Inhibitor Panobinostat in Colorectal Cancer Models

(2011) M. J. LaBonte et al.   CANCER RESEARCH

Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification

(2011) Minjia Tan et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Colorectal Cancer Epigenetics: Complex Simplicity

(2011) Manon van Engeland et al.   JOURNAL OF CLINICAL ONCOLOGY

SLC5A8 Gene, A Transporter of Butyrate: A Gut Flora Metabolite, Is Frequently Methylated in African American Colon Adenomas

(2011) Hassan Brim et al.   PLoS One

Gastrointestinal toxicity of vorinostat: reanalysis of phase 1 study results with emphasis on dose-volume effects of pelvic radiotherapy

(2011) Åse Bratland et al.   Radiation Oncology

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Histone deacetylase inhibitors: A chemical genetics approach to understanding cellular functions

(2010) Paul A. Marks   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Chromatin and DNA methylation dynamics of Helicobacter pylori-induced COX-2 activation

(2010) Raffaela Pero et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents

(2010) Jiahuai Tan et al.   Journal of Hematology & Oncology

Vorinostat, a histone deacetylase inhibitor, combined with pelvic palliative radiotherapy for gastrointestinal carcinoma: the Pelvic Radiation and Vorinostat (PRAVO) phase 1 study

(2010) Anne Hansen Ree et al.   LANCET ONCOLOGY

Recent advances in histone deacetylase targeted cancer therapy

(2010) Isamu Hoshino et al.   SURGERY TODAY

Comprehensive lysine acetylomes emerging from bacteria to humans

(2010) Go-Woon Kim et al.   TRENDS IN BIOCHEMICAL SCIENCES

Development of the pan-DAC inhibitor panobinostat (LBH589): Successes and challenges

(2009) Peter Atadja   CANCER LETTERS

High Efficacy of Panobinostat Towards Human Gastrointestinal Stromal Tumors in a Xenograft Mouse Model

(2009) G. Floris et al.   CLINICAL CANCER RESEARCH

Histone acetyltransferase Hbo1: Catalytic activity, cellular abundance, and links to primary cancers

(2009) Masayoshi Iizuka et al.   GENE

Isothiocyanates, glutathioneS-transferase M1 and T1 polymorphisms and gastric cancer risk: A prospective study of men in Shanghai, China

(2009) Kristin A. Moy et al.   INTERNATIONAL JOURNAL OF CANCER

New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer

(2009) Shundong Cang et al.   Journal of Hematology & Oncology

Vorinostat in solid and hematologic malignancies

(2009) David Siegel et al.   Journal of Hematology & Oncology

Multicenter phase II trial of the histone deacetylase inhibitor pyridylmethyl-N-{4-[(2-aminophenyl)-carbamoyl]-benzyl}-carbamate in pretreated metastatic melanoma

(2009) Axel Hauschild et al.   MELANOMA RESEARCH

Linking DNA methylation and histone modification: patterns and paradigms

(2009) Howard Cedar et al.   NATURE REVIEWS GENETICS

Class II histone deacetylases play pivotal roles in heat shock protein 90-mediated proteasomal degradation of vascular endothelial growth factor receptors

(2008) Jung-Hyun Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

(2008) Rui-Hong Wang et al.   CANCER CELL

HDAC family: What are the cancer relevant targets?

(2008) Olaf Witt et al.   CANCER LETTERS

A Phase I and Pharmacokinetic Study of the Oral Histone Deacetylase Inhibitor, MS-275, in Patients with Refractory Solid Tumors and Lymphomas

(2008) L. Gore et al.   CLINICAL CANCER RESEARCH

Class I Histone Deacetylase Expression Has Independent Prognostic Impact in Human Colorectal Cancer: Specific Role of Class I Histone Deacetylases In vitro and In vivo

(2008) W. Weichert et al.   CLINICAL CANCER RESEARCH

A Phase 1 Pharmacokinetic and Pharmacodynamic Study of the Histone Deacetylase Inhibitor Belinostat in Patients with Advanced Solid Tumors

(2008) N. L. Steele et al.   CLINICAL CANCER RESEARCH

Butyrate modulates oxidative stress in the colonic mucosa of healthy humans

(2008) Henrike M. Hamer et al.   CLINICAL NUTRITION

The Sirtuin family: therapeutic targets to treat diseases of aging

(2008) Jill C Milne et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Global Histone H4 Acetylation and HDAC2 Expression in Colon Adenoma and Carcinoma

(2008) Hassan Ashktorab et al.   DIGESTIVE DISEASES AND SCIENCES

Pharmacological inhibition of histone deacetylases for the treatment of cancer, neurodegenerative disorders and inflammatory diseases

(2008) Claire Bonfils et al.   Expert Opinion on Drug Discovery

Early phase II trial of oral vorinostat in relapsed or refractory breast, colorectal, or non-small cell lung cancer

(2008) Johan Vansteenkiste et al.   INVESTIGATIONAL NEW DRUGS

HDAC4 Promotes Growth of Colon Cancer Cells via Repression of p21

(2008) Andrew J. Wilson et al.   MOLECULAR BIOLOGY OF THE CELL

Deletion of Histone Deacetylase 3 Reveals Critical Roles in S Phase Progression and DNA Damage Control

(2008) Srividya Bhaskara et al.   MOLECULAR CELL

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Short Chain Fatty Acid Butyrate Induces Promoter Demethylation and Reactivation of RARβ2 in Colon Cancer Cells

(2008) Colleen C. Spurling et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth

(2008) Ron Firestein et al.   PLoS One