Article
Chemistry, Multidisciplinary
Jin-yi Liu, Wei-qi Fu, Xiang-jin Zheng, Wan Li, Li-wen Ren, Jin-hua Wang, Cui Yang, Guan-hua Du
Summary: Avasimibe demonstrated potent anticancer effects on human glioblastoma cells by inhibiting proliferation, inducing apoptosis, and regulating multiple signaling pathways. The drug showed promising potential as a chemotherapy treatment for glioblastoma.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Engineering, Biomedical
Fei Jiao, Jiayi Xu, Yang Zhao, Chongyang Ye, Qing Sun, Chenglin Liu, Bo Huo
Summary: This study investigates the synergistic effect of adhesion morphology and fluid flow on the behavior of mesenchymal stem cells (MSCs). The results show that adhesion patterns with low circularity and large area are beneficial for osteogenic differentiation of MSCs. Additionally, fluid shear stress (FSS) promotes osteogenic differentiation and enhances nuclear transfer of the transcriptional regulator Yes-associated protein (YAP) in MSCs. These findings are important for the design of bio-functional substrates for cell transplantation in tissue engineering.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Oncology
Niccolo Roda, Andrea Cossa, Roman Hillje, Andrea Tirelli, Federica Ruscitto, Stefano Cheloni, Chiara Priami, Alberto Dalmasso, Valentina Gambino, Giada Blandano, Andrea Polazzi, Paolo Falvo, Elena Gatti, Luca Mazzarella, Lucilla Luzi, Enrica Migliaccio, Pier Giuseppe Pelicci
Summary: This study identified the transcriptional programs underlying metastatic progression in breast cancer and provided prognostic signatures and prevention strategies.
Article
Biochemistry & Molecular Biology
Menghao Guo, Wenli Zhang, Shuyan Niu, Mengting Shang, Xiaoru Chang, Tianshu Wu, Ting Zhang, Meng Tang, Yuying Xue
Summary: Silver nanoparticles (AgNPs) are widely used for their antibacterial properties, but their use raises health concerns. This study evaluated the toxic effects of AgNPs on liver cells and found that the human hepatoma cell line (HepG2) was more sensitive to AgNPs than normal hepatic cell line (L02), possibly due to different responses to AgNPs by cancer cells and normal cells. N-acetylcysteine (NAC) was able to inhibit the increase in apoptosis induced by AgNPs and alleviate the imbalance of antioxidant system and cell cycle arrest. The knockdown of nuclear factor erythroid-derived factor 2-related factor (Nrf2) showed that Nrf2 has a protective role in AgNPs-induced hepatotoxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Cell Biology
Kasra Moeinabadi-Bidgoli, Malihe Rezaee, Hamidreza Rismanchi, Mohaddese Malek Mohammadi, Amirhesam Babajani
Summary: Mesenchymal stem cells-derived antimicrobial peptides have demonstrated anti-neoplastic effects by disrupting the membrane and interfering with intracellular pathways of neoplastic cells. This review discusses the potential anti-neoplastic effects of MSCs-derived antimicrobial peptides and their mechanisms, as well as the challenges in enhancing their production and delivery for clinical applications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mohamed M. Tawfik, Nourhan Eissa, Fayez Althobaiti, Eman Fayad, Ali H. Abu Almaaty
Summary: The study demonstrated the significant cytotoxic effect of Rhopilema nomadica jellyfish venom on liver cancer cells, inducing apoptosis in hepatocellular carcinoma cells. This is the first scientific evidence of the induction of apoptosis and cell cycle arrest by Rhopilema nomadica jellyfish venom.
Article
Biochemistry & Molecular Biology
Jing-Yan Gao, Chih-Shiang Chang, Jin-Cherng Lien, Ting-Wei Chen, Jing-Lan Hu, Jing-Ru Weng
Summary: Trytanthrin, a natural compound found in Ban-Lan-Gen, has anti-inflammatory and anti-viral properties. Two derivatives, A1 and A6, showed higher cytotoxicity in HCC cells and targeted multiple aspects of cancer cell growth, making them potential candidates for clinical applications.
Article
Multidisciplinary Sciences
Masaru Mizukoshi, Masaru Kaku, Lay Thant, Kohei Kitami, Moe Arai, Isao Saito, Katsumi Uoshima
Summary: The study revealed that periodontal ligament (PDL) cells exhibit dynamic proliferative characteristics during orthodontic tooth movement-induced tissue remodeling, with proliferative cells likely undergoing further division and contributing to tissue remodeling. Additionally, proliferating cells expressed various molecular markers, indicating the lineage plasticity of PDL cells in vivo.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Li-wen Ren, Wan Li, Xiang-jin Zheng, Jin-yi Liu, Yi-hui Yang, Sha Li, Sen Zhang, Wei-qi Fu, Bin Xiao, Jin-hua Wang, Guan-hua Du
Summary: Analysis of hub genes in GBM revealed benzimidazoles as potential anti-GBM agents, with in vivo studies showing their efficacy in suppressing tumor growth.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Jia-feng Tang, Guo-li Li, Tao Zhang, Yu-mei Du, Shi-ying Huang, Jian-hua Ran, Jing Li, Di-long Chen
Summary: In this study, it was found that HHT effectively inhibits the proliferation of melanoma cells by inducing DNA damage, apoptosis, and cell cycle arrest. Both in vitro and in vivo experiments confirmed the inhibitory effect of HHT on melanoma, providing evidence for its potential as an anti-melanoma agent.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Magdalena Markowicz-Piasecka, Karol Sadowski, Johanna Huttunen, Joanna Sikora, Kristiina M. Huttunen
Summary: Transporter-mediated cellular uptake of sulfonamide-based derivatives of metformin exhibited strong cytotoxic effects, inducing apoptosis and cell cycle arrest in breast cancer cells. These results suggest the potential of biguanides as anti-cancer agents through effective intracellular transport.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Ozlem Oz Gergin, Sibel Seckin Pehlivan, Menekse Ulger, Ozge Cengiz Mat, Adnan Bayram, Zeynep Burcin Gonen, Nur Seda Gokdemir, Cihangir Bicer, Karamehmet Yildiz, Arzu Hanim Yay
Summary: This study found that mesenchymal stem cells (MSCs) can protect against kidney injury induced by colistin. This protection is achieved by alleviating oxidative stress, modulating autophagy and apoptosis.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yaxin Sun, Beibei Sha, Wenjing Huang, Miaomiao Li, Shan Zhao, Yuan Zhang, Jie Yan, Zheng Li, Jingwen Tang, Peiyan Duan, Jianxiang Shi, Pei Li, Tao Hu, Ping Chen
Summary: This study demonstrates the cytotoxic effect of ML323 on esophageal squamous cell carcinoma (ESCC) cells and elucidates its underlying mechanisms. ML323 inhibits the growth of ESCC cells by blocking the cell cycle, inducing DNA damage, and triggering apoptosis through the p53-Noxa pathway. Additionally, ML323 stimulates autophagy in cells, and co-treatment with autophagy inhibitors enhances its cytotoxicity.
Article
Biotechnology & Applied Microbiology
Yayun Li, Pian Yu, Jing Long, Ling Tang, Xu Zhang, Zhe Zhou, DongSheng Cao, Juan Su, Xiang Chen, Cong Peng
Summary: AE007 is a promising therapeutic agent for melanoma by targeting RSK2 and inhibiting proliferation, migration, and invasion of melanoma cells without affecting normal skin cells.
Article
Multidisciplinary Sciences
Tae Woo Kim, Da-Won Hong, Sung Hee Hong
Summary: In this study, a novel benzothiazole derivative PB01 was shown to have antitumor effects in radiation-resistant human NSCLC cells by inducing cell death and inhibiting epithelial-to-mesenchymal transition. The mechanism involved induction of reactive oxygen species, ER stress, and activation of the ATR axis, suggesting that PB01 treatment could overcome radio-resistance during NSCLC radiotherapy.
SCIENTIFIC REPORTS
(2021)