Article
Materials Science, Multidisciplinary
Xiaoen Shi, Haizhen Guo, Xinlu Zhang, Xu Zhang, Chen Cao, Huan Li, Shutong Chen, Lei Han, Sheng Wang
Summary: Photodynamic therapy (PDT) is limited by tumor oxygen heterogeneity, but a novel oxygen level-responsive nanomedicine is reported here. This nanomedicine consists of a hypoxia-responsive molecule (Cy-NO2), a radical generator (ADVN), and a pH-responsive polymer. Under normoxic conditions, Cy-NO2 acts as a photosensitizer for effective PDT, while under hypoxic conditions, it transforms into a photothermal agent to generate toxic free radicals for thermodynamic therapy. This study offers a promising strategy for smart cancer therapy by overcoming oxygen heterogeneity.
ACS MATERIALS LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Nicholas J. Lyons, Rabina Giri, Jakob Begun, David Clark, David Proud, Yaowu He, John D. Hooper, Thomas Kryza
Summary: This article discusses the role of reactive oxygen species (ROS) in normal and malignant colonic cell biology and explores how existing and emerging therapies can utilize ROS for therapeutic benefit. Recent research has shed light on the contribution of ROS to the cytotoxicity of conventional chemotherapy, as well as the generation of ROS in response to excitatory stimuli in emerging therapies such as photodynamic therapy, sonodynamic therapy, and radiodynamic therapy. However, the poor prognosis and resistance associated with metastatic colorectal cancer necessitate the development of new and more effective treatments.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Chemistry, Multidisciplinary
Yujie Dai, Yiming Ding, Linlin Li
Summary: Nanozymes possess high catalytic activity and stability, making them advantageous in generating or eliminating reactive oxygen species (ROS) for potential applications in disease therapy. Researchers are exploring catalytic mechanisms and strategies to design nanozyme-based platforms for cancer therapy, pathogen infection, neurodegenerative diseases, and more. Challenges and future opportunities for the development and application of nanozymes are also being discussed.
CHINESE CHEMICAL LETTERS
(2021)
Article
Materials Science, Multidisciplinary
Shichen Zhang, Zhengqiang Li, Zhimin Xu, Yixin Tang, Congcong Duan, Huanyan Dai, Xinyu Dai, Xin Wei, Yan Liu, Caina Xu, Bing Han
Summary: Head and neck squamous cell carcinoma (HNSCC) is a common type of head and neck cancer. Traditional treatments can have negative effects on physiological functions and appearance. This article discusses the use of reactive oxygen species (ROS)-based cancer therapy and summarizes various nanotherapeutics for HNSCC, including photodynamic therapy, sonodynamic therapy, radiation therapy, and chemodynamic therapy. The challenges and future directions for these treatments are also discussed.
MATERIALS & DESIGN
(2022)
Article
Biochemistry & Molecular Biology
Seong-Won Yang, Young-Il Jeong, Min-Suk Kook, Byung-Hoon Kim
Summary: Folic acid-conjugated nanophotosensitizers showed ROS-sensitive properties and could be delivered to cancer cells via a folate receptor-mediated pathway, making them promising candidates for targeted photodynamic therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Health Care Sciences & Services
Chiaki Komine, Satoshi Uchibori, Osamu Tsudukibashi, Yasuhisa Tsujimoto
Summary: This article reviews the basic effects of ROS in dental medicine, especially endodontic therapy, and discusses future applications of ROS.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Engineering, Biomedical
Jie Chen, Xiaomin Tan, Yanjuan Huang, Congjun Xu, Zishan Zeng, Ting Shan, Zilin Guan, Xiaoyu Xu, Zeqian Huang, Chunshun Zhao
Summary: In this study, a reactive oxygen species-activatable self-amplifying prodrug nanoagent was developed for the tumor-specific dual-activation of chemotherapy and photodynamic therapy. The results showed a significant tumor-killing effect with little systemic toxicity.
Review
Chemistry, Analytical
Hao Yu, Binjie Chen, Huiming Huang, Zhentao He, Jiangman Sun, Guan Wang, Xinggui Gu, Ben Zhong Tang
Summary: Photodynamic therapy is a non-invasive approach for tumor elimination that is gaining increasing attention. The development of aggregation-induced emission (AIE) active photosensitizers has opened up new possibilities for overcoming the limitations of traditional photodynamic therapy.
Article
Engineering, Biomedical
Yunxiu Zhang, Qingyan Jia, Fuchun Nan, Jian Wang, Ke Liang, Jian Li, Xiaokuang Xue, Haohui Ren, Weimin Liu, Jiechao Ge, Pengfei Wang
Summary: In this study, three types of red-emissive carbon dots (RCDs) were successfully prepared with maximum emission at approximately 680 nm. The RCDs exhibited adjustable generation of reactive oxygen species (ROS) through type I and type II photodynamic therapy (PDT). The unique ROS formation of RCDs was determined by their core sizes and surface states, and they were able to induce cell programmed death via activating mitochondrion-mediated apoptotic pathways. This work provides a new prospect for RCDs as nanophotosensitizers to overcome the limitations of single type PDT.
Review
Immunology
Dandan Wu, Xuehui Chen, Shuqiu Zhou, Bin Li
Summary: Glioma, the most common primary intracranial tumor in adults, has poor prognosis. Current treatment methods, including surgery and chemoradiotherapy, have limited efficacy. The emerging field of nanotechnology offers a new approach called reactive oxygen species (ROS)-based nanotherapy, which generates large amounts of ROS in glioma cells to effectively eliminate the tumor. Nanotechnology also provides strategies to cross the blood-brain barrier, allowing effective ROS-based nanotherapy for glioma. This review summarizes the application of ROS-based nanomedicine in glioma treatment and discusses the current challenges and future prospects for clinical translation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Chemistry, Analytical
Nurul Mutmainnah Amal, Muhandis Shiddiq, Bidayatul Armynah, Dahlang Tahir
Summary: This review explores the relationship between the fluorescence mechanism of high-photoluminescence carbon dots (CDs) and the production of reactive oxygen species (ROS), and discusses their potential applications in photodynamic therapy (PDT) and anticancer material. The review also summarizes the preparation methods and characteristics of CDs, and provides prospects for their future development.
Article
Pharmacology & Pharmacy
Jose Garces-Garces, Miguel Sanchez-Martos, Gema Martinez-Navarrete, Eduardo Fernandez-Jover, Mirela Encheva, Martin Leon, Javier Ortiz, Angela Sastre-Santos, Fernando Fernandez-Lazaro
Summary: The synthesis and characterization of two new water soluble perylenediimides, PDI-1 and PDI-2, with potential applications in anticancer activities were described. These compounds demonstrated high fluorescence quantum yield in water and showed selective cytotoxicity toward cancer cells when exposed to specific light wavelength. The findings provide a strong foundation for the future exploration of PDI-1 and PDI-2 as effective photosensitizers in photodynamic therapy.
Article
Biochemistry & Molecular Biology
Hiromi Kurokawa, Hiromu Ito, Hirofumi Matsui
Summary: This study evaluated the specific accumulation of PLP in cancer cells and its cytotoxic effects on cholangiocarcinoma cells. Results showed that the cytotoxic effect of PLP PDT in cancer cells was significantly stronger than in normal cells. Additionally, reactive oxygen species regulated the intracellular accumulation of PLP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Seong-Yeong Heo, Yeachan Lee, Tae-Hee Kim, Soo-Jin Heo, Hwarang Shin, Jiho Lee, Myunggi Yi, Hyun Wook Kang, Won-Kyo Jung
Summary: Chlorophyllin-assisted photodynamic therapy has shown strong anti-cancer effects on human cervical cancer by inducing apoptosis through oxidative stress. The optimal conditions for photodynamic therapy have been determined, and it regulates the expression of several proteins and suppresses the phosphorylation of AKT1. Overall, chlorophyllin-assisted photodynamic therapy has the potential to be used as an antitumor therapy for cervical cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Lizhen Zhang, Chengyuan Zhu, Rongtao Huang, Yanwen Ding, Changping Ruan, Xing-Can Shen
Summary: Inorganic nanomaterials are gaining attention for biomedical applications due to their unique physicochemical properties. Cancer therapeutics like photodynamic therapy, sonodynamic therapy, and chemical dynamic therapy mediated by reactive oxygen species have potential to enhance therapeutic precision and efficacy for cancer treatment. The development of inorganic nanomaterials for generating ROS in cancer therapy is a promising area of research.
FRONTIERS IN CHEMISTRY
(2021)
