Article
Chemistry, Multidisciplinary
Yihao Zhou, Jinyi Dong, Chao Zhou, Qiangbin Wang
Summary: Using three-dimensional DNA origami as the building block, it is practical to construct finite hierarchical nanostructures with complicated conformations through orthogonal and directional bonding.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Hangbo Zhao, Xu Cheng, Changsheng Wu, Tzu-Li Liu, Qinai Zhao, Shuo Li, Xinchen Ni, Shenglian Yao, Mengdi Han, Yonggang Huang, Yihui Zhang, John A. Rogers
Summary: Three-dimensional, hierarchical micro/nanostructures formed with advanced functional materials have broad potential utility. Among various strategies in 3D micro/nanofabrication, compressive buckling-based methods offer material compatibility, fabrication scalability, and precise process control. This paper presents a hierarchical assembly concept that utilizes multiple layers of prestretched elastomeric substrates to create multi-level 3D mesostructures in complex frameworks.
ADVANCED MATERIALS
(2022)
Article
Engineering, Biomedical
X. Deng, A. Hasan, S. Elsharkawy, E. Tejeda-Montes, N. Tarakina, G. Greco, E. Nikulina, J. M. Stormonth-Darling, N. Convery, J. C. Rodriguez-Cabello, A. Boyde, N. Gadegaard, N. M. Pugno, M. Al-Jawad, A. Mata
Summary: Material platforms based on interaction between organic and inorganic phases have great potential to recreate the structural and functional properties of biological systems. The integration of a protein-based mineralizing matrix with surface topographies allows for the growth of spatially guided mineralized structures. Systematic modifications of surface topographies demonstrate the possibility of selectively guiding the growth of hierarchically mineralized structures.
MATERIALS TODAY BIO
(2021)
Review
Chemistry, Multidisciplinary
Yuanchen Dong, Yang Yang, Chenxiang Lin, Dongsheng Liu
Summary: This article introduces the recent progress of the frame-guided assembly (FGA) strategy in the preparation of customized amphiphile assemblies. FGA utilizes various nanomaterials with controlled properties as scaffolds to achieve precise control over the assembly morphology of amphiphiles. Different types of FGA assemblies, including inner-frame, outer-frame, and planar-frame, have distinct advantages and applications. FGA has been applied in liposome engineering, membrane protein incorporation, and drug delivery, showcasing its huge potential in fabricating novel and functional complexes.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Nada Farag, Gianfranco Ercolani, Erica Del Grosso, Francesco Ricci
Summary: In this study, we demonstrate the use of DNA repair enzymes to control the assembly of DNA-based structures. By designing responsive nucleic acid modules and utilizing specific enzyme repair activity, we were able to achieve the self-assembly of DNA tiles into tubular structures. This approach is programmable, specific, and orthogonal, allowing for accurate prediction of tile distribution. Additionally, we show that BER-enzyme inhibitors can be used to control DNA-tile assembly in a specific and concentration-dependent manner.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
Tao Chen, Sha Yang, Qinzhen Li, Yongbo Song, Guang Li, Jinsong Chai, Manzhou Zhu
Summary: Hierarchical assemblies of a new silver nanocluster, Ag-70-TPP, have been synthesized and characterized, showing a highly space-efficient double helical 4H close packing pattern directed by ligands. The chirality of Ag-70-TPP and van der Waals forces interactions between ligands play a key role in driving its arrangement, with observed interlocking of phosphine ligands contributing to the structure. This work provides important and unprecedented insights into the internal structure and crystallographic arrangement of nanoclusters.
NANOSCALE HORIZONS
(2021)
Article
Chemistry, Multidisciplinary
Shujing Huang, Min Ji, Yong Wang, Ye Tian
Summary: In this study, we successfully crystallized anisotropic elongated octahedral DNA origami frames into highly ordered superlattices using non-specific connections, providing a new approach for building three-dimensional functional devices with simple design.
Article
Chemistry, Multidisciplinary
Shujing Huang, Min Ji, Yong Wang, Ye Tian
Summary: In this study, the anisotropic elongated octahedral DNA origami frames with non-specific connections were crystallized to form simple cubic and simple tetragonal superlattices. This work deepens the understanding of geometry-guided crystallization of DNA origami shapes and provides a new path for constructing three-dimensional functional devices with simple design.
Article
Multidisciplinary Sciences
Lizhi Dai, Xiaoxue Hu, Min Ji, Ningning Ma, Hang Xing, Jun- Jie Zhu, Qianhao Min, Ye Tian
Summary: Harnessing the programmable nature of DNA origami, researchers have demonstrated the ability to control structural features in crystalline materials and achieve different equilibrium phases and shapes using a single DNA origami morphology. By modulating the binding coordination with an allosteric factor, the DNA origami crystals undergo phase transitions and yield diverse crystal systems. This approach opens up new possibilities for developing crystalline materials with tunable properties and accessing a rich phase space.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Oliver G. Hayes, Benjamin E. Partridge, Chad A. Mirkin
Summary: This study demonstrates the deliberate control of hierarchical assembly of protein-DNA materials by exploiting the chemical anisotropy of proteins and the programmability of DNA ligands. The introduction of orthogonal DNA interactions with disparate strengths onto specific geometric regions of a model protein leads to directional assembly and increased multi valency through DNA sequence design. The judicious DNA design not only directs assembly along a specific pathway but also influences distinct structural outcomes from a single pathway.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Mingfei Zhao, Kacper J. Lachowski, Shuai Zhang, Sarah Alamdari, Janani Sampath, Peng Mu, Christopher J. Mundy, Jim Pfaendtner, James J. De Yoreo, Chun-Long Chen, Lilo D. Pozzo, Andrew L. Ferguson
Summary: This study utilized molecular dynamics simulations and experimental observations to reveal the assembly mechanism of amphiphilic diblock peptoids in organic solvent/water mixtures, confirming the formation of 1D helical rods and 2D crystalline sheets during assembly. The findings establish new principles and understanding for the design of peptoid-based nanomaterials.
Article
Chemistry, Multidisciplinary
Yunlong Zhang, Donglei Yang, Pengfei Wang, Yonggang Ke
Summary: Structural DNA nanotechnology enables the fabrication of designer nanoscale artificial architectures. In this study, we developed a molecular assembly system where DNA tiles can assemble into tubes and then large one-dimensional DNA bundles. By incorporating a cohesive link into the tiles, we induced intertube binding and successfully formed DNA bundles with micrometer-length and nanometer-width, whose assembly was collectively determined by cationic strength and linker designs. Moreover, programmable spatial features and compositions of multicomponent DNA bundles were realized. Lastly, dynamic capability was implemented to achieve reversible reconfigurations among tile, tube, and bundles. This assembly strategy expands the toolbox of DNA nanotechnology and has broad applications in materials science, synthetic biology, biomedical science, and beyond.
Article
Mathematics
Alexandru Amarioarei, Frankie Spencer, Gefry Barad, Ana-Maria Gheorghe, Corina Itcus, Iris Tusa, Ana-Maria Prelipcean, Andrei Paun, Mihaela Paun, Alfonso Rodriguez-Paton, Romica Trandafir, Eugen Czeizler
Summary: Recent advances in computational modeling and simulation have brought computer scientists into the forefront of engineering new nanomaterials and nanodevices. The intrinsic self-assembly properties of DNA have been proven highly algorithmic and programmable, making it a versatile and functional nanomaterial. By studying the assembly characteristics of DNA and other bio-nanomaterials, potential for more effective control over structural patterns is uncovered.
Article
Chemistry, Multidisciplinary
Andreas Frank, Christian Hils, Melina Weber, Klaus Kreger, Holger Schmalz, Hansooo-Werner Schmidt
Summary: By matching the functional groups of the surface patches on polymer fibers with the corresponding substituents of BTAs, specific superstructures can be induced.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Biochemistry & Molecular Biology
Ke Li, Yanfei Liu, Beibei Lou, Yifu Tan, Liwei Chen, Zhenbao Liu
Summary: In the past decades, DNA has been widely utilized in the field of nanostructures due to its programmable properties. This review presents different strategies for the functionalization of DNA on nanoparticle surfaces and discusses the roles of DNA in the assembly of nanostructures as well as the influencing factors. The biomedical applications of DNA-assembled nanostructures are also summarized. This review provides new insights into the application of DNA in nanostructure assembly.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)