Article
Chemistry, Multidisciplinary
Shinichiro Ido, Kei Kobayashi, Noriaki Oyabu, Yoshiki Hirata, Kazumi Matsushige, Hirofumi Yamada
Summary: Water structuring on the outer surface of protein molecules, known as the hydration shell, is crucial for the biological activities of protein molecules in vivo. The three-dimensional force mapping technique has been successfully used to investigate the molecular-scale hydration structure of native purple membrane patches.
Article
Chemistry, Multidisciplinary
Nathaniel Prine, Zhiqiang Cao, Song Zhang, Tianyu Li, Changwoo Do, Kunlun Hong, Camille Cardinal, Travis L. Thornell, Sarah E. Morgan, Xiaodan Gu
Summary: Atomic-force microscopy coupled with infrared spectroscopy (AFM-IR) simultaneously maps surface morphology and chemical composition of thin-film polymer blends and composites. Overlapping infrared absorption bands between different species make quantitative analysis challenging. Isotope labeling with carbon-deuterium vibration allows distinguishing blend phases and enables nanoscale domain composition analysis.
Article
Chemistry, Multidisciplinary
Siyuan Ye, Wenzhe Li, Huayi Wang, Ling Zhu, Chen Wang, Yanlian Yang
Summary: In this study, the nanomechanical properties of human breast cancer cell-derived sEVs were quantitatively investigated using atomic force microscopy (AFM). It was found that the stiffness and osmotic pressure of sEVs increase with malignancy and decrease with size, while the bending modulus decreases with malignancy and is lower in smaller sEVs. This research establishes a relationship between the nanomechanical signature of sEVs and tumor malignancy, contributing to a better understanding of cancer mechanobiology.
Article
Chemistry, Multidisciplinary
Levente Juhasz, Roberto D. Ortuso, Kaori Sugihara
Summary: The study utilized quantitative friction force microscopy to measure the response of polydiacetylene to lateral forces, revealing the necessity of applying shear forces to characterize it at the nanoscale. The experiment confirmed the erroneous nature of the hypothesis regarding the higher force sensitivity at the edges and discovered a correlation between mechanochromism and thermochromism.
Article
Nanoscience & Nanotechnology
Philipp Rahe, Daniel Heile, Reinhard Olbrich, Michael Reichling
Summary: This article discusses the influence of inclined sampling paths on data interpretation in dynamic atomic force microscopy (AFM), especially for measurements on nanostructured surfaces with significant lateral force. The inclination of the tip movement can have critical consequences for data interpretation, and the authors propose measuring along a path parallel to the oscillation direction to reliably recover the force.
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ammar Alkhalde, Hannah Seferovic, Ali Abri, Alvana Simbrunner, Peter Hinterdorfer, Yoo Jin Oh
Summary: A new corneal crosslinking method called Bubble-CXL was introduced, which used intracameral oxygen as an additional oxygen source during the treatment. The use of intracameral oxygen resulted in increased biomechanical stability of the cornea.
Article
Physics, Applied
Abhilash Chandrashekar, Pierpaolo Belardinelli, Stefano Lenci, Urs Staufer, Farbod Alijani
Summary: This study successfully increased the sensitivity of higher harmonics of an atomic force microscope cantilever through dynamic mode coupling, achieving tuning of harmonic frequencies while reducing sample indentation. The results of the study indicate that nonlinear mode coupling is one of the reasons for the increase in the amplitude of higher harmonics.
PHYSICAL REVIEW APPLIED
(2021)
Article
Chemistry, Physical
Yuyao Zhang, Xiaoying Zhu, Bokai Zhu, Chiheng Chu, Baoliang Chen
Summary: The hydrophobicity of nanomaterials plays a crucial role in various interfacial phenomena. However, it is challenging to study the high-resolution surface hydrophobicity at the nanoscale. In this study, a chemical force microscopy technique is used to profile in situ hydrophobicity images with nanoscale resolution, providing significant improvement compared to traditional methods. The method is applied to recognize the spatial fine structure hydrophobicity of different materials and reveals new findings regarding the hydrophobicity of graphene oxides (GO) and the influence of wrinkles/edges on hydrophobicity. Furthermore, the technique enables the observation of local oxidation variation during interfacial reactions.
Article
Biochemistry & Molecular Biology
Yuhui Wei, Kaizhe Wang, Qinglin Xia, Bin Li, Lin Liu
Summary: In this study, atomic force microscopy was used to achieve nanoscale resolution 3D imaging of microvilli in living cells, revealing the morphological classification and dynamic characteristics of microvilli clusters. The findings provide important insights into the morphology and function of cell membranes and associated structures.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Zibo Li, Qian Liu, Qiang Li, Mingdong Dong
Summary: This study investigates the lubrication effect of hydrated halogen anions on positively charged surfaces using atomic force microscopy and friction force microscopy. The results show that the mechanical properties of the hydration layers depend on the concentration of electrolyte solutions, and the friction coefficient and friction dissipation are significantly lower at low concentrations. Superlubricity can be achieved in low concentration electrolyte solution. These findings provide insights into the origins of hydration lubrication.
Article
Polymer Science
Tuyet Anh Pham, Seunghoe Koo, Hyunseok Park, Quang Thien Luong, Oh Joong Kwon, Segeun Jang, Sang Moon Kim, Kyeongtae Kim
Summary: The Nafion(R) electrolyte membrane plays a crucial role in fuel cell systems, and thermal treatment is an effective method for improving membrane mechanical properties. The microscopic mechanical properties rapidly increase and saturate near 150 degrees Celsius, while the macroscopic properties continue to increase until 250 degrees Celsius.
Article
Chemistry, Multidisciplinary
Haruhiko Eki, Katsuhiko Abe, Hiroshi Sugiyama, Masayuki Endo
Summary: This study used atomic force microscopy to directly observe the formation and degradation of tensegrity triangle DNA crystals at a molecular level, visualizing the dynamic process and characterizing them with nanoscale resolution.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Juan F. Gonzalez-Martinez, Hannah Boyd, Philipp Gutfreund, Rebecca J. L. Welbourn, Carolina Robertsson, Claes Wickstrom, Thomas Arnebrant, Robert M. Richardson, Stuart W. Prescott, Robert Barker, Javier Sotres
Summary: The study found that MUC5B mucin films can maintain hydration and protect interfaces under certain mechanical confinement. However, further technological developments are required to investigate these films under the sample environment of neutron reflectometry.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Keivan Asadi, Junghoon Yeom, Hanna Cho
Summary: Investigating internal resonance (IR) mechanisms in micro/nanoresonators reveals that intermodal coupling between second and third flexural modes in asymmetric structures provides an optimal condition for strong IR, with high energy transfer to the resonated mode. This study introduces design strategies that can be easily integrated into typical micro/nanoelectromechanical systems, offering potential for paradigm-shifting applications in micro/nanosystems.
MICROSYSTEMS & NANOENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Mark D. Eddleston, Ernest H. H. Chow, Dejan-Kresimir Bucar, Ranjit Thakuria
Summary: In this study, in situ atomic force microscopy was employed to investigate topological crystal surface defects and their role in the dissociation of the caffeine-glutaric acid cocrystal at high relative humidity. The topographical scans revealed that the dissociation occurs through localized sublimation, increased molecular surface diffusion, the formation of line and screw dislocations, and the crystallization of caffeine hydrate.
Article
Engineering, Mechanical
Deliang Zhang, Yuge Zhang, Qiang Li, Mingdong Dong
Summary: The study found that environmental adsorbates play an important role in load-dependent friction hysteresis in graphene, leading to a positive friction hysteresis. After the removal of environmental adsorbates, a negative friction hysteresis was observed.
Article
Chemistry, Physical
Zibo Li, Qian Liu, Qiang Li, Mingdong Dong
Summary: This study investigates the lubrication effect of hydrated halogen anions on positively charged surfaces using atomic force microscopy and friction force microscopy. The results show that the mechanical properties of the hydration layers depend on the concentration of electrolyte solutions, and the friction coefficient and friction dissipation are significantly lower at low concentrations. Superlubricity can be achieved in low concentration electrolyte solution. These findings provide insights into the origins of hydration lubrication.
Article
Engineering, Environmental
Jiatian Chen, Zihang Huang, Hongqian Zhang, Zhongyang Zhang, Donghui Wang, Dan Xia, Chuanxu Yang, Mingdong Dong
Summary: In this study, a three-dimensional layered nanofiber sponge was successfully prepared, which achieved timely absorption of exudate, accelerated hemostasis, and inhibited bacterial growth and inflammation by incorporating silver-metal organic framework and curcumin. The sponge showed excellent hemostasis and coagulation effect, as well as remarkable antibacterial effect and good cytocompatibility. In vivo experiments confirmed its high wound healing efficiency.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Ziwei Su, Xiangxiang Zhang, Weichen Wang, Mingdong Dong, Xiaojun Han
Summary: This study demonstrates an efficient way to build self-powered artificial cells containing thylakoids that convert light energy into chemical energy to supply ATP. The generated ATP and NADPH can be used in promoting biological enzyme cascade reactions and provide a pathway for building more complex artificial cells.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Dan Xia, Yuan Liu, Wuxiu Cao, Junwei Gao, Donghui Wang, Mengxia Lin, Chunyong Liang, Ning Li, Ruodan Xu
Summary: Coaxial electrospinning nanofibrous patches combining anti-bacterial and anti-inflammation agents have the potential to accelerate wound healing, which is achieved through co-loading and sequential release of drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Rongrong Wu, Xinwen Ou, Liwei Zhang, Xiaolu Song, Zengkai Wang, Mingdong Dong, Lei Liu
Summary: The study demonstrates that electric field can inhibit the co-fibrillation of multiple amyloid peptides, preventing the formation of fibril aggregates and promoting the formation of amorphous particles. The inhibitory effect is attributed to the disruption of the secondary structure of amyloid peptides under small static EF, while maintaining the strong interaction between different peptides. This finding suggests the potential of noninvasive treatment for amyloid-related diseases.
Article
Nuclear Science & Technology
Shichang Dong, Shengjie Gong, Botao Zhang, Yidan Yuan, Weimin Ma
Summary: This study establishes a new prediction model for critical heat flux (CHF) in subcooled flow boiling at low pressure. The model accurately predicts the effects of thermal-hydraulic and geometric factors on CHF and demonstrates good adaptability to non-water systems.
PROGRESS IN NUCLEAR ENERGY
(2022)
Article
Materials Science, Multidisciplinary
Deliang Zhang, Zibo Li, Lasse Hyldgaard Klausen, Qiang Li, Mingdong Dong
Summary: This article summarizes the friction behaviors and underlying physical mechanisms of 2D materials, with an increased understanding of their friction properties thanks to the development of atomic and friction force microscopy. The effects of atomic structures and external factors on friction, as well as strategies for friction modulation, are discussed. The challenges in practical applications of 2D materials as atomically thin lubricants and the prospects for future progression are also provided.
MATERIALS TODAY PHYSICS
(2022)
Article
Thermodynamics
Botao Zhang, Shengjie Gong, Shichang Dong, Zhenqin Xiong, Qiang Guo
Summary: Boiling-induced vibration characteristics and mechanisms were investigated in pool boiling experiments. Turbulence and bubble collapse were identified as the two main mechanisms causing vibration. The peak amplitude of the first natural frequency increased with increasing heat flux and decreasing subcooling degree for turbulence-induced vibration. The peak amplitude of the second natural frequency increased with increasing heat flux for a certain subcooled temperature above 10 degrees C, and remained stable for lower subcooled temperatures. The dominant mechanism transitioned from bubble collapse to turbulence with decreasing subcooled temperature for a certain heat flux. The highest root-mean-square (RMS) value of vibration velocity corresponded to an increasing subcooled temperature with increasing heat flux.
APPLIED THERMAL ENGINEERING
(2023)
Article
Nanoscience & Nanotechnology
Shengjie Liang, Mengyuan Hu, Baoe Li, Dan Xia, Chunyong Liang, Feng Peng, Donghui Wang
Summary: This study reports on the development of an intelligent implant capable of detecting and disinfecting early bacterial adhesion. The implant integrates a biosensor electrode based on AC impedance technology to monitor the growth and elimination of E.coli. The biosensor electrode showed high correlation with classical OD monitoring and was able to eradicate bacteria on the electrode surface. In vitro cellular experiments also demonstrated the biocompatibility and bone differentiation-promoting effect of the PPy coating.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Jiatian Chen, Zihang Huang, Xiaotong Wu, Dan Xia, Ziyu Chen, Donghui Wang, Chunyong Liang, Jinhua Li
Summary: In this paper, a three-dimensional (3D) nanofiber sponge with dimethyloxaloglycine (DMOG) loaded mesoporous spheres of derivatives of Prussian blue analogues (PBAs) was prepared. The nanostructure, composition, and mechanical properties of the nanofiber sponge were characterized, showing regular nanostructure and good mechanical property. The study demonstrated that the 3D-PBA(FeCo)-DMOG nanofiber sponge could provide a new strategy for promoting angiogenesis and wound healing for clinical applications.
BIOMEDICAL MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Rongrong Wu, Zengkai Wang, Zili Jia, Chenglong Li, Jie Wang, Lei Liu, Mingdong Dong
Summary: This study investigates the cross-fibrillation of A beta peptides and different hIAPP structures. The experimental results show that hIAPP aggregates enhance the fibrillation of A beta, especially hIAPP fibrils. Using quantitative nanomechanical mapping and molecular dynamic simulations, different hybrid amyloid strains can be distinguished based on their mechanical properties and structural transformations.
Article
Multidisciplinary Sciences
Steven J. Roeters, Kris Strunge, Kasper B. Pedersen, Thaddeus W. Golbek, Mikkel Bregnhoj, Yuge Zhang, Yin Wang, Mingdong Dong, Janni Nielsen, Daniel E. Otzen, Birgit Schiott, Tobias Weidner
Summary: This study reports a mechanism explaining why lipid membranes catalyze the formation of harmful aggregates at elevated concentrations.
NATURE COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Mingrui Zhang, Ying Zhang, Wei Mu, Mingdong Dong, Xiaojun Han
Summary: The bottom-up construction of artificial cells using chemically synthesized lipid analogues allows for better understanding of cellular mechanisms. This article describes four methods of synthesizing lipid analogues and their use in constructing and division of artificial cells. Challenges and future directions in this field are also discussed.
Review
Chemistry, Multidisciplinary
Dan Xia, Jiatian Chen, Zhongyang Zhang, Mingdong Dong
Summary: The demand for patients' organ and tissue repair and regeneration is increasing. However, autologous or allograft treatments are often hindered by issues such as donor shortage and possible rejection. Artificial constructs that mimic the extracellular matrix have been developed as substitutes to promote cell attachment and differentiation, ultimately forming functional tissues or organs. Polymeric materials have been widely used in regenerative medicine due to their manufacturing ease, flexibility, biocompatibility, and good mechanical, chemical, and thermal properties. This review provides a comprehensive overview of various polymeric materials and their applications, as well as discussing the challenges and perspectives in the development and clinical transformation of these biomaterials.
