Review
Chemistry, Multidisciplinary
Zhimin Chai, Anthony Childress, Ahmed A. Busnaina
Summary: Nanofabrication based on directed assembly, utilizing external fields to interact with nanoelements and assemble functional structures, is attracting more interest recently due to its low cost and additive manufacturing advantages. The external fields used in directed assembly include electric, fluidic flow, magnetic, and optical fields.
Article
Chemistry, Multidisciplinary
Renjie Niu, Fei Gao, Dou Wang, Dan Zhu, Shao Su, Shufen Chen, Lihui YuWen, Chunhai Fan, Lianhui Wang, Jie Chao
Summary: A DNA origami-directed pattern recognition strategy is utilized to assemble AuNCs into shape-controllable PGNs, creating localized field enhancement in gaps to generate hot spots for stronger single-molecule SERS signals.
Review
Chemistry, Multidisciplinary
Chuanping Li, Yongdong Jin
Summary: Shell-isolated nanostructures, with inert shells and plasmonic cores, have emerged as promising platforms for biosensing, catalysis, and nanoelectronics applications. These structures not only enhance the detectability of biosensors, but also provide a strong foundation for exploring plasmonic enhancement principles. Furthermore, they are advancing the field of advanced nanoelectronics by revealing new electron transport mechanisms and enabling the development of new optoelectronic devices.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Maximilian Ochs, Luka Zurak, Enno Krauss, Jessica Meier, Monika Emmerling, Rene Kullock, Bert Hecht
Summary: This study demonstrates the selective electrical excitation of symmetric and antisymmetric plasmonic modes in a two-wire transmission line. Mode selectivity is achieved by precisely positioning nanoscale excitation sources. The resulting device represents the smallest electrically driven light source with directly switchable polarization states.
Article
Chemistry, Analytical
Kai-Xin Xie, Qian Liu, Shu-Shu Jia, Xiu-Xian Xiao
Summary: The introduction of a hollow plasmonic structure led to enhanced surface plasmon-coupled emission (SPCE), resulting in significant fluorescence signal enhancements. This was primarily attributed to the unique hot-spot plasmonic structure between GNS and gold substrate, the intense electromagnetic field of GNSs, and the strong coupling interactions between fluorescence and surface plasmons.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Multidisciplinary
John J. Cully, Jacob L. Swett, Kyle Willick, Jonathan Baugh, Jan A. Mol
Summary: The synthesis of low-dimensional materials with unique properties has opened up new possibilities for creating hybrid nanomaterial devices. However, challenges remain in integrating individual nanoparticles into devices at scale. A graphene nanogap platform has been developed to address this issue, allowing for the capture and integration of single nanoparticles for applications in novel devices and optoelectronics.
Article
Chemistry, Multidisciplinary
Shuailong Zhang, Weizhen Li, Mohamed Elsayed, Jiaxi Peng, Yujie Chen, Yanfeng Zhang, Yibo Zhang, Moein Shayegannia, Wenkun Dou, Tiancong Wang, Yu Sun, Nazir P. Kherani, Steven L. Neale, Aaron R. Wheeler
Summary: A method based on optoelectronic tweezers for forming topographical micropatterns (TMPs) has been reported, showing promise in constructing structures in the field of microelectronics. This technique demonstrates the ability to create permanent structures that can be harvested and transferred, paving the way for new applications in microelectronics.
Article
Materials Science, Multidisciplinary
Zeying Zhang, Maoxiong Zhao, Meng Su, Yali Sun, Ekaterina Ponkratova, Shuang-Jie Tan, Qi Pan, Bingda Chen, Zheng Li, Zheren Cai, Huadong Wang, Dongdong Wu, Lei Shi, Yanlin Song
Summary: This study reports a general method for visualizable detection and measurement of nanoscale objects using one-dimensional nanostructures. Large-scale 1D nanostructures, prepared through template-assisted self-assembly of colloidal nanoparticles, can significantly amplify the weak optical signals from nanoscale objects, achieving detection sensitivity down to the single-particle level. The rapid and ultrasensitive testing of different clinical virus samples using a simple optical microscope or a portable cell phone is demonstrated. This work showcases a label-free, simple, and high-efficiency optical detection platform at the nanoscale, with a broad range of applications.
Review
Chemistry, Multidisciplinary
David Vila-Liarte, Nicholas A. Kotov, Luis M. Liz-Marzan
Summary: The acquisition of strong chiroptical activity has revolutionized the field of plasmonics, enabling new light-matter interactions. Self-assembly of achiral nanoparticles into optically active materials simplifies engineering of chiral geometries and allows for control of structure-optical activity relationships in nanostructures. Chiral structures like helical assemblies and patterned substrates are reviewed as platforms for chiral sensing, with future potential for incorporating semiconductor emitters into plasmonic systems to generate circularly polarized photoluminescence.
Article
Chemistry, Multidisciplinary
Ganghuo Pan, Jie Leng, Liye Deng, Liwen Xing, Rui Feng
Summary: Controllable self-assembly plays a crucial role in the design and development of materials, with various factors influencing the process. Understanding and controlling self-assembly behaviors is considered a challenge, but studying the mechanical action of W-based complex powder provides insights into the formation of diverse structures and shapes.
CRYSTAL GROWTH & DESIGN
(2021)
Article
Chemistry, Multidisciplinary
Mamoru Tamura, Takuya Iida, Kenji Setoura
Summary: This study demonstrates through numerical simulation that spatial shaping of nanoscale temperature fields can be achieved by plasmonic heating of a single TiN nanostructure. The low thermal conductivity of TiN compared to metals like Au allows for clear transcription of heat power density distributions into temperature fields.
Article
Chemistry, Multidisciplinary
Xiao-Yun Yan, Qing-Yun Guo, Zhiwei Lin, Xian-You Liu, Jun Yuan, Jing Wang, Haomin Wang, Yuchu Liu, Zebin Su, Tong Liu, Jiahao Huang, Ruimeng Zhang, Yicong Wang, Mingjun Huang, Wei Zhang, Stephen Z. D. Cheng
Summary: By assembling T-shaped amphiphiles, polymeric molecular frameworks with good solution processability and thermal stability were successfully constructed, revealing their internal structure and demonstrating great potential in scalable fabrications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Physics, Applied
Filippos Harlaftis, Dean Kos, Qianqi Lin, Kevin T. P. Lim, Calvin Dumesnil, Jeremy J. J. Baumberg
Summary: Dielectrophoresis is found to drive the motion of nanoparticles through the interaction of their induced dipoles with a non-uniform electric field. The reversible aggregation of 100 nm diameter gold nanoparticles in electrode gaps is experimentally observed under MHz frequencies. A frequency resonance is observed, resulting in a significant increase in the density of gold nanoparticle clouds. A simple model is proposed to explain this reversibility, suggesting the possibility of substantial control over nanoparticle separation.
APPLIED PHYSICS LETTERS
(2022)
Article
Materials Science, Multidisciplinary
Yasamin Ziai, Francesca Petronella, Chiara Rinoldi, Pawel Nakielski, Anna Zakrzewska, Tomasz A. Kowalewski, Weronika Augustyniak, Xiaoran Li, Antonella Calogero, Izabela Sabala, Bin Ding, Luciano De Sio, Filippo Pierini
Summary: One of the fascinating areas in the field of smart biopolymers is biomolecule sensing. This article presents an innovative platform composed of nanocomposite hydrogels and electrospun materials for glucose sensing applications.
NPG ASIA MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Xinshuang Gao, Qiang Zheng, Hanbo Li, Chenqi Zhang, Rui Cai, Yinglu Ji, Zhijian Hu, Xiaochun Wu
Summary: Recently, the combination of seed-mediated growth and thiolated chiral molecule-guided growth has shown promise in obtaining chiral plasmonic nanostructures. In this study, the roles of non-chiral cationic surfactants in helical growth were investigated. The counter anion and hydrocarbon chain length of the surfactants were found to greatly affect the formation of helical shells, allowing for surfactant-modulated conversion between layer growth and island growth. Optimized growth conditions resulted in a significant plasmonic circular dichroism (PCD) response, demonstrating the potential of nanochemical synthesis in fabricating chiral plasmonic nanostructures with small structural sizes.
Review
Chemistry, Analytical
Seda Nur Topkaya, Arif E. Cetin
Summary: Aptamers are short, single-stranded DNA or RNA molecules with high sensitivity to interact with various targets, such as biomarkers, cells, biological molecules, drugs or chemicals. They offer advantages over antibodies in terms of easier preparation and modification, higher stability, lower variability and cost. Aptamers can be easily integrated with sensors, biosensors, actuators, and other devices for improved detection capabilities in medical applications.
Review
Chemistry, Analytical
Huseyin Oguzhan Kaya, Arif E. Cetin, Mostafa Azimzadeh, Seda Nur Topkaya
Summary: Detection of pathogens, such as bacteria and viruses, remains a challenge in analytical medicine, but utilizing electrochemical methods can achieve rapid, inexpensive, specific, and sensitive detection. Electrochemical biosensors have made significant advances in the detection of bacteria and viruses, showing a wide range of potential applications.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Gorkem Liman, Emrecan Yildiz, Hasan Ilhan, Arif E. Cetin, Gokhan Demirel
Summary: A new strategy in the field of SERS is proposed, which manipulates hot-spot formations by controlling the folding of polymeric materials, resulting in a 70-fold enhancement of the Raman signal. Successful sample collection and analysis have been achieved through magnetic field control of platform motion and folding manipulation, demonstrating new possibilities for sensing applications.
ADVANCED OPTICAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Arif E. Cetin, Seda Nur Topkaya, Ozden Yalcin-Ozuysal, Ali Khademhosseini
Summary: This paper introduces a plasmonic functional assay platform for precise measurement of cell weight and real-time dynamic changes in adherent cells, allowing for determination of growth rates and heterogeneity within populations. The platform successfully differentiated growth profiles of populations and assessed subpopulations exhibiting distinct growth profiles, demonstrating potential for broad applications in basic research and clinical settings.
Article
Biophysics
Seda Nur Topkaya, Idil Karaca Acari, Huseyin Oguzhan Kaya, Imren Ozcan, Suleyman Koytepe, Arif E. Cetin
Summary: This article presents an electrochemical biosensor utilizing graphite electrodes decorated with NiFe2O4 nanoparticles for nucleic acid detection. The synthesized NiFe2O4 nanoparticles showed a diameter of around 10 nm and high surface area and conductivity on the electrode surface. The interactions between NiFe2O4 nanoparticles and nucleic acids were effectively examined for the first time using various electrochemical analysis methods, demonstrating successful interaction via an electrostatic mode.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Arif E. Cetin, Seda Nur Topkaya, Ziya Ata Yazici, Ozden Yalcin-Ozuysal
Summary: Functional assay platforms can identify the biophysical properties of cells and their therapeutic response to drug treatments. Single-cell functional assays can overcome the limitations of traditional assays and reveal drug resistance. We developed a high-throughput plasmonic functional assay platform to simultaneously monitor cell growth and therapeutic response to drugs. This platform has the potential for rapid assessment of cell therapy and personalized drug treatments.
Article
Chemistry, Physical
Arif E. Cetin
Summary: This article introduces a portable plasmonic biosensor kit for the detection of Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) bacteria in urine samples. The platform combines label-free plasmonic nanohole sensing with lens-free computational imaging, revolutionizing point-of-care pathogen diagnosis. The system captures and analyzes diffraction field images, uncovering subtle bacterial presence cues.
Article
Chemistry, Physical
Vagif Nevruzoglu, Murat Tomakin, Melih Manir, Selcuk Demir, Fatih Saban Beris, Arif E. Cetin
Summary: Plasmonic nanoparticles with distinct nearfield properties are promising for label-free biosensing applications. A cryogenic temperature method for vacuum evaporation is proposed to produce nanoparticles with homogenous size distribution and high structural quality, enabling the excitation of plasmonic resonances with narrower linewidths and more controlled dimensions. The method shows enhanced refractive index sensitivity and larger spectral shifts within plasmonic resonances compared to the classical vacuum deposition technique.
Article
Chemistry, Analytical
Meryem Beyza Avci, S. Deniz Yasar, Arif E. Cetin
Summary: Cell-counting is crucial for various applications in life sciences, medicine, and pharmacology, but manual counting under a microscope is slow and limited by operator experience. Automated cell-counting devices with image recording and processing capabilities can improve accuracy and throughput. However, these devices still need further improvement in accuracy, and the test cost increases due to the need for compatible consumables. To address these drawbacks, we introduced an optofluidic cell-counting platform that can scan over 2000 cells, significantly improving test accuracy. The platform delivers count results in about 1 minute and eliminates the need for an external counting chamber.
ANALYTICAL METHODS
(2023)
Article
Automation & Control Systems
Gorkem Liman, Emre Ergene, Emrecan Yildiz, Kubra Ozkan Hukum, Pinar Yilgor Huri, Arif E. Cetin, Hakan Usta, Gokhan Demirel
Summary: By decorating plasmonic nanoparticles on magnetic actuators, we demonstrate a new soft actuator platform that can generate reversible and tunable hot-spots in millimeter-sized areas via bending motion. The hot-spot formation is shown to be reversible and adjustable, with Raman signal enhancements of up to approximately 120 folds compared to the unactuated platforms. The accessible electromagnetic field magnification in the platform can be manipulated by controlling magnetic field strength. Additionally, a centipede-inspired robot is fabricated and used for sample collection/analysis in a target environment.
ADVANCED INTELLIGENT SYSTEMS
(2023)
Article
Engineering, Electrical & Electronic
Sena Yaman, Meryem Beyza Avci, Fatma Kurul, Seda Nur Topkaya, Arif E. Cetin
Summary: We have developed a lensfree optofluidic platform for label-free identification of biomolecular interactions. Our platform is compact, portable, and utilizes microfluidics and on-chip computational imaging. The experimental results demonstrate the high sensing capabilities and cost-effective infrastructure of our platform, making it a promising tool for biosensing applications.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Proceedings Paper
Engineering, Biomedical
Fatma Kurul, Ziya Ata Yazici, Zeynep A. Kocer, Seda Nur Topkaya, Arif E. Cetin
Summary: The development of rapid diagnostic kits is crucial for early diagnosis and treatment of infectious diseases. This study introduces a lightweight and portable biosensor that utilizes a plasmonic chip based on nanohole arrays integrated into a lens-free imaging system for label-free virus detection in field settings. The biosensor platform employs a high-efficiency CMOS camera to observe the diffraction field patterns of nanohole arrays, enabling reliable and accurate detection of H1N1 viruses at medically relevant concentrations. The platform technology is adaptable and can be used for detecting other viral diseases such as COVID-19 or influenza by modifying the plasmonic chip surface.
TRANSLATIONAL BIOPHOTONICS: DIAGNOSTICS AND THERAPEUTICS III
(2023)
Proceedings Paper
Engineering, Biomedical
Meryem Beyza Avci, Seda Nur Topkaya, Ozden Yalcin-Ozuysal, Ali Khademhosseini, Arif E. Cetin
Summary: A new platform has been developed to measure the weight and growth of individual cells in real time, allowing for quick measurement of cell growth in small samples and determination of differences in cell population growth and cancer cells' response to drug treatment.
TRANSLATIONAL BIOPHOTONICS: DIAGNOSTICS AND THERAPEUTICS III
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Zeynep Ovgu Yayci, Ugur Dura, Zeynep Betul Kaya, Arif E. Cetin, Mehmet Turkan
Summary: This study aims at addressing the issues of illumination, contrast, color aberration, blur, and noise in low-cost microscopes at high image magnification rates. By utilizing principal component analysis and feature map processing, the proposed method produces sharper, and better color and illumination fixed outputs.
2022 IEEE INTERNATIONAL CONFERENCE ON IMAGE PROCESSING, ICIP
(2022)
Article
Nanoscience & Nanotechnology
Zhiliang Zhang, Feng Zhao, Renxian Gao, Chih-Yu Jao, Churong Ma, Jie Li, Xiangping Li, Bai-Ou Guan, Arif E. Cetin, Kai Chen
Summary: This article introduces a plasmonic sensor based on gold nanohole arrays that can achieve real-time, label-free, and high-sensitivity biosensing. The authors demonstrated narrow-band high-order resonances enabled by Rayleigh anomaly in the nanohole arrays fabricated by scalable colloidal lithography. They also introduced a spectrometer-free refractive index sensing method based on lens-free smartphone imaging of the nanohole arrays. The work shows potential for highly sensitive and compact point-of-care devices with cost-effective and high-throughput plasmonic chips.