Journal
ACS NANO
Volume 7, Issue 10, Pages 8561-8572Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn402642a
Keywords
DNA; polymers; temperature responsive; surfactants; nanoparticles
Categories
Funding
- Advantage West Midlands (AWM)
- European Regional Development Fund (ERDF)
- EPSRC [EP/G037930/1]
- Royal Society-Wolfson Research Merit Award
- Engineering and Physical Sciences Research Council [EP/G004897/1, GR/A10274/01, EP/F008597/1, EP/F055803/1, EP/F056605/1] Funding Source: researchfish
- EPSRC [EP/F055803/1, EP/F008597/1, EP/G004897/1, EP/F056605/1] Funding Source: UKRI
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Copper catalyzed azide-alkyne cycloaddition (CuAAC) was employed to synthesize DNA block copolymers (DBCs) with a range of polymer blocks including temperature-responsive poly(N-isoproylacrylamide) (poly(NIPAM)) and highly hydrophobic poly(styrene). Exceptionally high yields were achieved at low DNA concentrations, in organic solvents, and in the absence of any solid support. The DNA segment of the DBC remained capable of sequence-specific hybridization: it was used to assemble a precisely defined nanostructure, a DNA tetrahedron, with pendant poly(NIPAM) segments. In the presence of an excess of poly(NIPAM) homopolymer, the tetrahedron poly(NIPAM) conjugate nucleated the formation of large, well-defined nanoparticles at 40 degrees C, a temperature at which the homopolymer precipitated from solution. These composite nanoparticles were observed by dynamic light scattering and cryoTEM, and their hybrid nature was confirmed by AFM imaging. As a result of the large effective surface area of the tetrahedron, only very low concentrations of the conjugate were required in order for this surfactant-like behavior to be observed.
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