Journal
ACS NANO
Volume 2, Issue 5, Pages 921-927Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn800177v
Keywords
DNA-complexes; cationic lipid; polyhedral oligomeric silsesquioxane; conformation; self-assembly
Categories
Funding
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [0968846] Funding Source: National Science Foundation
Ask authors/readers for more resources
In this work, a novel cube-shaped cationic lipid based on the imidazolium salt of polyhedral oligomeric silsesquioxane (POSS) was complexed with double-stranded DNA. Because of the negative spontaneous curvature of the cationic POSS imidazolium lipid, an inverted hexagonal phase resulted above the melting point of POSS crystals. Depending on the competition between the crystallization of POSS molecules and the negative spontaneous curvature of cationic POSS imidazolium lipids, different self-assembled phase morphologies were obtained. A lamellar phase was obtained when the POSS crystallization was relatively slow. When the POSS crystallization was fast, an inverted hexagonal phase was obtained with POSS lamellar crystals grown in the interstitials of DNA cylinders. On the basis of a circular dichroism study, double-stranded DNA adopted the B-form helical conformation in the inverted hexagonal phase, whereas the helical conformation was largely destroyed in the lamellar phase.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available