Journal
ACS CHEMICAL NEUROSCIENCE
Volume 4, Issue 10, Pages 1334-1338Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cn400128s
Keywords
chemosensor; neurotransmitter; logic gate; exocytosis; fluorescence
Funding
- National Science Foundation [CHE-1112194]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1112194] Funding Source: National Science Foundation
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A dual-analyte fluorescent chemosensor (ExoSensor 517) for the direct visualization of neurotransmitters released upon exocytosis is presented. The sensor exploits the high concentration of neurotransmitters (e.g., glutamate, norepinephrine, and dopamine) and the pH gradient between the vesicle and synaptic cleft. The cooperative recognition elements require both binding and a change in environmental pH to afford a fluorescence response which makes ExoSensor 517 one of the first integrated molecular logic gates to be used for biological applications.
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