Journal
ACS CHEMICAL BIOLOGY
Volume 3, Issue 4, Pages 203-206Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cb800065s
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A recent study challenges the oft-held notion that ester bonds in prodrug molecules are cleaved rapidly and completely inside cells by endogenous, nonspecific esterases. Structure-activity relationship studies on acylated sugars reveal that regioisomeric compounds display disparate biological activity, suggesting that ester bonds can persist in a cellular context.
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