Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 10, Issue 36, Pages 30155-30162Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b10421
Keywords
pure photosensitizer; DiR; self-assembly; theragnostics; photothermal therapy
Funding
- National Basic Research Program of China (973 Program) [2015CB932100]
- National Natural Science Foundation of China [81703451]
- China Postdoctoral Science Foundation [2017M611269, 2018T110233]
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Imaging-guided diagnosis and phototherapy has been emerging as promising theragnostic strategies for detection and treatment of cancer. 1,1'-Dioctadecyl-3,3,3',3'-tetramethylindotricarbocyanine iodide (DiR) has been widely investigated for in vivo imaging and photothermal therapy (PTT). However, the tumor-homing ability and PTT efficiency of DiR is greatly limited by its extremely low water solubility and nonspecific distribution in off-target tissues. Herein, a facile nanoassembly of pure DiR is reported as a theragnostic nanocarrier platform for imaging-guided antitumor phototherapy. Self-assembly of DiR has almost no effect on its in vitro photothermal efficacy when compared with DiR solution. Interestingly, the PEGylated nanoassemblies of DiR showed distinct advantages over DiR solution and non-PEGylated nanoassemblies in terms of systemic circulation and tumor-homing capability in vivo. As a result, PEGylated DiR nanoassemblies demonstrate potent photothermal tumor therapy in BALB/c mice bearing 4T1 xenograft tumors. Such a pure photosensitizer-based nanoassembly holds great potential as a versatile platform for efficient imaging-guided cancer therapy.
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