The multiple facets of FcRn in immunity

Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics

(2015) Amita Datta-Mannan et al.   mAbs

pH-dependent Binding Engineering Reveals an FcRn Affinity Threshold That Governs IgG Recycling

(2014) M. Jack Borrok et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dissection of the Neonatal Fc Receptor (FcRn)-Albumin Interface Using Mutagenesis and Anti-FcRn Albumin-blocking Antibodies

(2014) Kine Marita Knudsen Sand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms

(2014) Vaheh Oganesyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophages eliminate circulating tumor cells after monoclonal antibody therapy

(2014) Nuray Gül et al.   JOURNAL OF CLINICAL INVESTIGATION

The MHC Class II-Associated Invariant Chain Interacts with the Neonatal Fc  Receptor and Modulates Its Trafficking to Endosomal/Lysosomal Compartments

(2014) L. Ye et al.   JOURNAL OF IMMUNOLOGY

Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge

(2014) Bing Li et al.   mAbs

On the Perplexingly Low Rate of Transport of IgG2 across the Human Placenta

(2014) Helga K. Einarsdottir et al.   PLoS One

Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

(2014) C. A. Diebolder et al.   SCIENCE

There’s been a Flaw in Our Thinking

(2014) Clark L. Anderson   Frontiers in Immunology

The Role of FcRn in Antigen Presentation

(2014) Kristi Baker et al.   Frontiers in Immunology

IgG Subclasses and Allotypes: From Structure to Effector Functions

(2014) Gestur Vidarsson et al.   Frontiers in Immunology

Inhibition of HPA-1a alloantibody-mediated platelet destruction by a deglycosylated anti-HPA-1a monoclonal antibody in mice: toward targeted treatment of fetal-alloimmune thrombocytopenia

(2013) T. Bakchoul et al.   BLOOD

Maternofetal transplacental transport of recombinant IgG antibodies lacking effector functions

(2013) L. Mathiesen et al.   BLOOD

A prominent lack of IgG1-Fc fucosylation of platelet alloantibodies in pregnancy

(2013) R. Kapur et al.   BLOOD

An IgG3 switch variant of rituximab mediates enhanced complement-dependent cytotoxicity against tumour cells with low CD20 expression levels

(2013) Thies Rösner et al.   BRITISH JOURNAL OF HAEMATOLOGY

Neonatal Fc Receptor Expression in Dendritic Cells Mediates Protective Immunity against Colorectal Cancer

(2013) Kristi Baker et al.   IMMUNITY

Intranasal Administration of Antibody-Bound Respiratory Syncytial Virus Particles Efficiently Primes Virus-Specific Immune Responses in Mice

(2013) D. Kruijsen et al.   JOURNAL OF VIROLOGY

Influence ofFCGRTgene polymorphisms on pharmacokinetics of therapeutic antibodies

(2013) Christophe Passot et al.   mAbs

Multivalent immune complexes divert FcRn to lysosomes by exclusion from recycling sorting tubules

(2013) Andrew W. Weflen et al.   MOLECULAR BIOLOGY OF THE CELL

H435-containing immunoglobulin G3 allotypes are transported efficiently across the human placenta: implications for alloantibody-mediated diseases of the newborn

(2013) Helga Einarsdottir et al.   TRANSFUSION

Antibodies and Their Receptors: Different Potential Roles in Mucosal Defense

(2013) Rachel E. Horton et al.   Frontiers in Immunology

Efficiency of immunoglobulin G replacement therapy in common variable immunodeficiency: correlations with clinical phenotype and polymorphism of the neonatal Fc receptor

(2012) V. Gouilleux-Gruart et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Comparison of the Fc glycosylation of fetal and maternal immunoglobulin G

(2012) Helga K. Einarsdottir et al.   GLYCOCONJUGATE JOURNAL

Crosstalk between Human IgG Isotypes and Murine Effector Cells

(2012) M. B. Overdijk et al.   JOURNAL OF IMMUNOLOGY

Electron tomography of late stages of FcRn-mediated antibody transcytosis in neonatal rat small intestine

(2012) Mark S. Ladinsky et al.   MOLECULAR BIOLOGY OF THE CELL

How nascent phagosomes mature to become phagolysosomes

(2012) Gregory D. Fairn et al.   TRENDS IN IMMUNOLOGY

Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor

(2012) Jan Terje Andersen et al.   Nature Communications

The Neonatal FcR-Mediated Presentation of Immune-Complexed Antigen Is Associated with Endosomal and Phagosomal pH and Antigen Stability in Macrophages and Dendritic Cells

(2011) X. Liu et al.   JOURNAL OF IMMUNOLOGY

A Neonatal Fc Receptor-Targeted Mucosal Vaccine Strategy Effectively Induces HIV-1 Antigen-Specific Immunity to Genital Infection

(2011) L. Lu et al.   JOURNAL OF VIROLOGY

FcRn overexpression in mice results in potent humoral response against weakly immunogenic antigen

(2011) Attila Végh et al.   mAbs

Intracellular neutralization of viral infection in polarized epithelial cells by neonatal Fc receptor (FcRn)-mediated IgG transport

(2011) Y. Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells

(2011) K. Baker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential

(2011) Nigel M. Stapleton et al.   Nature Communications

An intracellular traffic jam: Fc receptor-mediated transport of immunoglobulin G

(2010) Devin B Tesar et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Genetic Polymorphisme of FCGRT Encoding FcRn in a Japanese Population and Their Functional Analysis

(2010) Akiko Ishii-Watabe et al.   Drug Metabolism and Pharmacokinetics

Neonatal FcR Overexpression Boosts Humoral Immune Response in Transgenic Mice

(2010) J. Cervenak et al.   JOURNAL OF IMMUNOLOGY

Reduced elimination of IgG antibodies by engineering the variable region

(2010) T. Igawa et al.   PROTEIN ENGINEERING DESIGN & SELECTION

N-Glycan Moieties in Neonatal Fc Receptor Determine Steady-state Membrane Distribution and Directional Transport of IgG

(2009) Timothy T. Kuo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity

(2009) Salit Tzaban et al.   JOURNAL OF CELL BIOLOGY

FcRn in the Yolk Sac Endoderm of Mouse Is Required for IgG Transport to Fetus

(2009) J. Kim et al.   JOURNAL OF IMMUNOLOGY

IgG is transported across the mouse yolk sac independently of FcγRIIb

(2009) Sudhasri Mohanty et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Nanogold as a Specific Marker for Electron Cryotomography

(2009) Yongning He et al.   MICROSCOPY AND MICROANALYSIS

Tickets to ride: selecting cargo for clathrin-regulated internalization

(2009) Linton M. Traub   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Specificity and affinity of human Fc  receptors and their polymorphic variants for human IgG subclasses

(2008) P. Bruhns et al.   BLOOD

Human IgG2 Antibodies Display Disulfide-mediated Structural Isoforms

(2008) Jette Wypych et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Characterization of Disulfide Isoforms of the Human IgG2 Subclass

(2008) Thomas M. Dillon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FcRn-mediated antibody transport across epithelial cells revealed by electron tomography

(2008) Wanzhong He et al.   NATURE

Dependence of antibody-mediated presentation of antigen on FcRn

(2008) S.-W. Qiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ca2+-dependent Calmodulin Binding to FcRn Affects Immunoglobulin G Transport in the Transcytotic Pathway

(2007) Bonny L. Dickinson et al.   MOLECULAR BIOLOGY OF THE CELL