Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 6, Issue 20, Pages 17446-17453Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am5059519
Keywords
mesoporous silica nanoparticles; drug delivery; pH-controlled release; pH-responsive charge-reversal polymer; doxorubicin hydrochloride
Funding
- National Natural Science Foundation of China [21175029, 21335002]
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Therapeutic platforms such as chemotherapy that respond to physical and biological stimuli are highly desirable for effective cancer therapy. In this study, pH-responsive charge-reversal, polymer-coated mesoporous silica nanoparticles [PAH-cit/APTES-MSNs; PAH-cit refers to poly(allylamine)-citraconic anhydride; APTES refers to (3-aminopropyl)triethoxysilane] were synthesized for application as drug-delivery systems for the treatment of malignant cells. Confocal laser scanning microscopy (CLSM) revealed that the PAH-cit/APTES-MSNs nanocomposite effectively delivered and released doxorubicin hydrochloride to the nucleus of HeLa (human cervical carcinoma) cells. Additionally, the real-time dynamic drug-release process was monitored by CLSM. The current pH-controlled-smart-release platform holds promise in drug-delivery and cancer therapy-related applications.
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