Human KIR repertoires: shaped by genetic diversity and evolution

Epigenetic Modification and Antibody-Dependent Expansion of Memory-like NK Cells in Human Cytomegalovirus-Infected Individuals

(2015) Jaewon Lee et al.   IMMUNITY

The Structure of the Atypical Killer Cell Immunoglobulin-like Receptor, KIR2DL4

(2015) Shoeib Moradi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peptide-Dependent Recognition of HLA-B*57:01 by KIR3DS1

(2015) Geraldine M. O'Connor et al.   JOURNAL OF VIROLOGY

The role of the maternal immune system in the regulation of human birthweight

(2015) A. Moffett et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

AKIR Bcentromeric region present in Africans but not Europeans protects pregnant women from pre-eclampsia

(2015) Annettee Nakimuli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

KIR ligand C2 is associated with increased susceptibility to childhood ALL and confers an elevated risk for late relapse

(2014) F. Babor et al.   BLOOD

Deconstructing the Peptide-MHC Specificity of T Cell Recognition

(2014) Michael E. Birnbaum et al.   CELL

Tracing dynamic expansion of human NK-cell subsets by high-resolution analysis of KIR repertoires and cellular differentiation

(2014) Vivien Béziat et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Synergistic Polymorphism at Two Positions Distal to the Ligand-Binding Site Makes KIR2DL2 a Stronger Receptor for HLA-C Than KIR2DL3

(2014) A. K. Moesta et al.   JOURNAL OF IMMUNOLOGY

Of snowflakes and natural killer cell subsets

(2014) Lewis L Lanier   NATURE BIOTECHNOLOGY

Beyond model antigens: high-dimensional methods for the analysis of antigen-specific T cells

(2014) Evan W Newell et al.   NATURE BIOTECHNOLOGY

Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations

(2014) Faviel F. González-Galarza et al.   NUCLEIC ACIDS RESEARCH

Activating killer cell immunoglobulin-like receptor 2DS2 binds to HLA-A*11

(2014) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The CD94/NKG2C+ NK-cell subset on the edge of innate and adaptive immunity to human cytomegalovirus infection

(2014) Miguel López-Botet et al.   SEMINARS IN IMMUNOLOGY

Progression to AIDS in SIV-Infected Rhesus Macaques is Associated with Distinct KIR and MHC class I Polymorphisms and NK Cell Dysfunction

(2014) Christina Albrecht et al.   Frontiers in Immunology

NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs

(2013) V. Beziat et al.   BLOOD

A comprehensive analysis of the binding of anti-KIR antibodies to activating KIRs

(2013) K Czaja et al.   GENES AND IMMUNITY

Large Spectrum of HLA-C Recognition by Killer Ig-like Receptor (KIR)2DL2 and KIR2DL3 and Restricted C1 Specificity of KIR2DS2: Dominant Impact of KIR2DL2/KIR2DS2 on KIR2D NK Cell Repertoire Formation

(2013) G. David et al.   JOURNAL OF IMMUNOLOGY

Killer Ig-like Receptor 2DL4 Does Not Mediate NK Cell IFN-  Responses to Soluble HLA-G Preparations

(2013) M. E. L. Le Page et al.   JOURNAL OF IMMUNOLOGY

Genome-Wide siRNA Screen Reveals a New Cellular Partner of NK Cell Receptor KIR2DL4: Heparan Sulfate Directly Modulates KIR2DL4-Mediated Responses

(2013) M. Brusilovsky et al.   JOURNAL OF IMMUNOLOGY

HLA-F and MHC Class I Open Conformers Are Ligands for NK Cell Ig-like Receptors

(2013) J. P. Goodridge et al.   JOURNAL OF IMMUNOLOGY

Expression Patterns of Killer Cell Immunoglobulin-Like Receptors (KIR) of NK-Cell and T-Cell Subsets in Old World Monkeys

(2013) Meike Hermes et al.   PLoS One

Genetic and Environmental Determinants of Human NK Cell Diversity Revealed by Mass Cytometry

(2013) A. Horowitz et al.   Science Translational Medicine

Modulation of the natural killer cell KIR repertoire by cytomegalovirus infection

(2012) Hojjatollah N. Charoudeh et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Copy number variation leads to considerable diversity for B but not A haplotypes of the human KIR genes encoding NK cell receptors

(2012) W. Jiang et al.   GENOME RESEARCH

Mutation at Positively Selected Positions in the Binding Site for HLA-C Shows That KIR2DL1 Is a More Refined but Less Adaptable NK Cell Receptor Than KIR2DL3

(2012) H. G. Hilton et al.   JOURNAL OF IMMUNOLOGY

Human-specific evolution of killer cell immunoglobulin-like receptor recognition of major histocompatibility complex class I molecules

(2012) P. Parham et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Allele-Level Haplotype Frequencies and Pairwise Linkage Disequilibrium for 14 KIR Loci in 506 European-American Individuals

(2012) Cynthia Vierra-Green et al.   PLoS One

The role of classical and non-classical HLA class I antigens in human tumors

(2012) Juergen Bukur et al.   SEMINARS IN CANCER BIOLOGY

Neonatal NK-cell repertoires are functionally, but not structurally, biased toward recognition of self HLA class I

(2011) K. Schonberg et al.   BLOOD

Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function

(2011) B. Foley et al.   BLOOD

The extreme plasticity of killer cell Ig-like receptor (KIR) haplotypes differentiates rhesus macaques from humans

(2011) Jeroen H. Blokhuis et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CMV drives clonal expansion of NKG2C+NK cells expressing self-specific KIRs in chronic hepatitis patients

(2011) Vivien Béziat et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Diversity of killer cell immunoglobulin-like receptor genes in four ethnic groups in China

(2011) Yufeng Yao et al.   IMMUNOGENETICS

Structure/function of human killer cell immunoglobulin-like receptors: lessons from polymorphisms, evolution, crystal structures and mutations

(2011) Kerry S. Campbell et al.   IMMUNOLOGY

A Molecular Phylogeny of Living Primates

(2011) Polina Perelman et al.   PLoS Genetics

Analyses of HLA-C-specific KIR repertoires in donors with group A and B haplotypes suggest a ligand-instructed model of NK cell receptor acquisition

(2010) K. Schonberg et al.   BLOOD

A novel KIR-associated function: evidence that CpG DNA uptake and shuttling to early endosomes is mediated by KIR3DL2

(2010) S. Sivori et al.   BLOOD

A 72-kD B cell-associated surface glycoprotein expressed at high levels in hairy cell leukaemia and plasma cell neoplasms

(2010) K. PULFORD et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2

(2010) Susan E. Hiby et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus

(2010) Niklas K. Björkström et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Combined Genotypic and Phenotypic Killer Cell Ig-Like Receptor Analyses Reveal KIR2DL3 Alleles Displaying Unexpected Monoclonal Antibody Reactivity: Identification of the Amino Acid Residues Critical for Staining

(2010) M. Falco et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: KIR Antisense Transcripts Are Processed into a 28-Base PIWI-Like RNA in Human NK Cells

(2010) F. Cichocki et al.   JOURNAL OF IMMUNOLOGY

Human-Specific Evolution and Adaptation Led to Major Qualitative Differences in the Variable Receptors of Human and Chimpanzee Natural Killer Cells

(2010) Laurent Abi-Rached et al.   PLoS Genetics

Significant functional heterogeneity among KIR2DL1 alleles and a pivotal role of arginine245

(2009) R. Bari et al.   BLOOD

KIR acquisition probabilities are independent of self-HLA class I ligands and increase with cellular KIR expression

(2009) S. Andersson et al.   BLOOD

KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C

(2009) Thorsten Graef et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The genetics of inbreeding depression

(2009) Deborah Charlesworth et al.   NATURE REVIEWS GENETICS

Explaining worldwide patterns of human genetic variation using a coalescent-based serial founder model of migration outward from Africa

(2009) M. DeGiorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Co-evolution of KIR2DL3 with HLA-C in a human population retaining minimal essential diversity of KIR and HLA class I ligands

(2009) K. Gendzekhadze et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel System of Polymorphic and Diverse NK Cell Receptors in Primates

(2009) Anne Averdam et al.   PLoS Genetics

MHC class I-specific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response

(2008) M. Yawata et al.   BLOOD

Dramatically reduced surface expression of NK cell receptor KIR2DS3 is attributed to multiple residues throughout the molecule

(2008) C J VandenBussche et al.   GENES AND IMMUNITY

Up on the tightrope: natural killer cell activation and inhibition

(2008) Lewis L Lanier   NATURE IMMUNOLOGY

The Late Pleistocene Dispersal of Modern Humans in the Americas

(2008) T. Goebel et al.   SCIENCE

Worldwide Human Relationships Inferred from Genome-Wide Patterns of Variation

(2008) J. Z. Li et al.   SCIENCE

The Yin and Yang of HLA and KIR in human disease

(2008) Smita Kulkarni et al.   SEMINARS IN IMMUNOLOGY