Article
Chemistry, Multidisciplinary
Yuki Saito, Shu Kobayashi
Summary: The application of heterogeneous catalysts in continuous-flow enantioselective hydroacylation reactions was studied. Catalysts were prepared by mixing supports and rhodium complexes, and showed excellent activity and enantioselectivity. Under optimized conditions, the catalysts exhibited high turnover numbers and could be applied to various substrates. Furthermore, sequential-flow reactions with other heterogeneous catalysts were demonstrated for the synthesis of biologically active molecules and functional materials.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Yuki Saito, Ken Nishizawa, Benjamin Laroche, Haruro Ishitani, Shu Kobayashi
Summary: This study demonstrates the continuous-flow synthesis of (R)-tamsulosin without the need for the isolation or purification of any intermediates or byproducts. The synthesis was achieved through four catalytic transformations in a flow stream, resulting in a high yield and enantiomeric excess.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Polymer Science
Kirsten Bell, Sarah Freeburne, Michele Fromel, Hee Jeung Oh, Christian W. Pester
Summary: This study demonstrates a method of using fluorescein-functionalized polymers grafted to micro-scale glass beads as photocatalysts, with analysis conducted using X-ray photoelectron spectroscopy and thermogravimetric analysis, showcasing high yields in cyclic condensation and radical dehalogenation reactions.
JOURNAL OF POLYMER SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Tahani A. C. A. Bayrakdar, Camille Lescot
Summary: A simple Rh-based catalyst has been developed for the carbene transfer reaction of methyl diazoacetate (MDA) and various substrates under heterogeneous flow conditions. Two different methods for heterogenizing the catalyst in a column reactor have been successfully applied. The catalyst exhibited high activity and selectivity for functionalizing different X-H (X=O, S, Si, CH2) bonds and for cyclopropenation under mild continuous flow conditions. Catalyst recycling experiments showed that up to 5 catalytic cycles could be achieved for the carbene O-H insertion reaction, and a sequential transformation of different substrates with up to 10 consecutive runs per reactor was achieved without any loss in catalytic activity, allowing the production of compound families.
Article
Chemistry, Multidisciplinary
Yuki Saito, Shu Kobayashi
Summary: The article discusses the application of chiral heterogeneous Sc catalysts in continuous-flow reactions, achieving efficient synthesis of compounds through noncovalent interactions and the crucial role of heteropoly acid.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Applied
Mohanraj Kandasamy, Haruro Ishitani, Shu Kobayashi
Summary: A continuous-flow procedure for the synthesis of beta-ketoesters using a Sn-MCM-41 catalyst has been developed. This methodology showed good to excellent yields with a variety of aldehydes and diazoesters. The prepared beta-ketoesters were also successfully transformed into coumarin derivatives and 5-pyrazolone through sequential reactions.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Engineering, Environmental
Jingjun Qin, Zhang Liu, Weicheng Xu, Ximiao Zhu, Fawen Liang, Yutang Yu, Yuanzhi Zheng, Lang Yao, Honghua Zhang, Kaichun Lin, Jianzhang Fang, Zhanqiang Fang
Summary: This study reports the use of poly (triazine imide) (PTI) as an effective catalyst for activating peroxymonosulfate (PMS) to degrade micropollutants under visible light. The PTI nanoparticles exhibit photogenerated charge separation and transfer, resulting in the generation of singlet oxygen (1O2) for the complete removal of antibiotics. The immobilized PTI also shows high degradation and mineralization rates in a continuous flow reactor.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Organic
Wei-Hsin Hsu, Susanne Reischauer, Peter H. Seeberger, Bartholomaus Pieber, Dario Cambie
Summary: Metallaphotoredox catalysis is a versatile synthetic platform that enables mild cross-couplings without the need for noble metals. In this study, a continuous-flow approach using a heterogeneous catalyst that combines both photo- and nickel-catalysts in one material is reported. The catalyst is embedded in a packed-bed reactor, simplifying the translation from batch to continuous flow reactions. The catalyst exhibited stability and effectiveness in the metallaphotoredox cross-coupling reactions.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Dongyu Fan, Shahryar Ramezani Bajgiran, Farshad Safi Samghabadi, Chayan Dutta, Emil Gillett, Peter J. Rossky, Jacinta C. Conrad, Amanda B. Marciel, Christy F. Landes
Summary: In this work, we use 3D single-molecule tracking to study the transport behavior in a cationic poly(2-(N,N-dimethylamino)ethyl acrylate) (PDMAEA) brush using an anionic dye, Alexa Fluor 546, as the probe. Our results show that the spatial heterogeneity within the brush leads to heterogeneity of single-molecule displacements. We identify two distinct populations of probe motion, with anticorrelated axial and lateral transport confinement.
Article
Chemistry, Physical
Mickael Henrion, Yorck Mohr, Kwinten Janssens, Simon Smolders, Aram L. Bugaev, Oleg A. Usoltsev, Elsje Alessandra Quadrelli, Florian M. Wisser, Dirk E. De Vos, Jerome Canivet
Summary: New catechol-based porous polymers were synthesized and used as platforms for the heterogenization of molecular Cu complexes. The resulting Cu@CatMP-1 materials proved to be highly stable and performing catalysts with turnover numbers up to 6000, about 1 to 2 orders of magnitude higher than the current relevant state of the art. The solid catalyst showed recyclability for over 10 runs without metal leaching and has been scaled to the gram scale. The coordination of Cu to catechol within the polymer has been confirmed by X-ray absorption spectroscopy.
Article
Chemistry, Multidisciplinary
Qiang Chen, Yujun Wang, Guangsheng Luo
Summary: In this study, an enzyme-rich hydrogel monolithic microreactor was developed to achieve a self-sufficient cofactor system. The flow asymmetric production of chiral alcohols in this gel microreactor showed high selectivity and yield. Additionally, the cofactor utilization was significantly improved, and the catalyst exhibited improved product tolerance and storage stability.
Article
Chemistry, Multidisciplinary
Arianna Brandolese, David H. Lamparelli, Miquel A. . Pericas, Arjan W. Kleij
Summary: A commercially available Lipase B from Candida antarctica immobilized onto a macroporous support (Novozym 435) was used as a benign oxidant for the epoxidation of various biorenewable terpenes in the presence of H2O2. The epoxidation protocol was explored under both heterogeneous batch and continuous flow conditions. The catalyst showed good recyclability under batch conditions for 10 cycles and could be used for more than 30 hours under continuous flow operation. This sustainable flow epoxidation allows for the production of gram quantities of terpene epoxides and the post-functionalization of biobased polymers.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Francesco Ferlin, Ioannis Anastasiou, Nihad Salameh, Takeru Miyakoshi, Olivier Baudoin, Luigi Vaccaro
Summary: A heterogeneous catalyst has been prepared for the intramolecular activation/cyclization reaction to synthesize indolines. The catalyst showed high efficiency through a release and catch mechanism, facilitated by iodide ligands. The heterogeneous nature of the catalyst was further utilized in the design of a continuous-flow protocol, enabling efficient recovery and reuse.
Review
Chemistry, Applied
Xin Yuan, Jie Liu, Long-Zhou Qin, Jian Wang, Xiu Duan, Jiang -Kai Qiu, Kai Guo
Summary: Photoredox catalysis is considered an economically attractive and environmentally friendly method for chemical syntheses. However, recent studies have identified unresolved issues, such as the limited propagation distance of photons in traditional batch reactors. The introduction of continuous-flow technology has addressed these challenges and enabled various transformations in photochemical synthesis.
CHINESE JOURNAL OF CATALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Rafal Januszewski, Bartosz Orwat, Michal Dutkiewicz, Ireneusz Kownacki
Summary: This article presents a high-yield synthesis of a novel polymeric precursor and its subsequent functionalization through transition metal-catalyzed reactions. The demonstrated approach provides new opportunities for designing and synthesizing polymers with specific functional moieties.
MATERIALS TODAY CHEMISTRY
(2022)
Review
Chemistry, Applied
Rajesh Munirathinam, Jurriaan Huskens, Willem Verboom
ADVANCED SYNTHESIS & CATALYSIS
(2015)
Article
Chemistry, Multidisciplinary
Rajesh Munirathinam, Andrea Leoncini, Jurriaan Huskens, Herbert Wormeester, Willem Verboom
JOURNAL OF FLOW CHEMISTRY
(2015)
Article
Chemistry, Multidisciplinary
Rajesh Munirathinam, Dorothee Laurenti, Gerhard D. Pirngruber, Denis Uzio
Article
Chemistry, Organic
Rajesh Munirathinam, Roberto Ricciardi, Richard J. M. Egberink, Jurriaan Huskens, Michael Holtkamp, Herbert Wormeester, Uwe Karst, Willem Verboom
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2013)
Article
Chemistry, Multidisciplinary
Chidambar Kulkarni, Rajesh Munirathinam, Subi J. George
CHEMISTRY-A EUROPEAN JOURNAL
(2013)
Article
Chemistry, Multidisciplinary
Rajesh Munirathinam, Daejune Joe, Jurriaan Huskens, Willem Verboom
JOURNAL OF FLOW CHEMISTRY
(2012)
Article
Chemistry, Multidisciplinary
Rajesh Munirathinam, Jurriaan Huskens, Willem Verboom
JOURNAL OF FLOW CHEMISTRY
(2014)
Article
Chemistry, Multidisciplinary
Carmen Stoffelen, Rajesh Munirathinam, Willem Verboom, Jurriaan Huskens
MATERIALS HORIZONS
(2014)
Review
Engineering, Chemical
Rajesh Munirathinam, Doan Pham Minh, Ange Nzihou
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2018)
Article
Chemistry, Physical
Rajesh Munirathinam, Doan Pham Minh, Ange Nzihou
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2020)
Review
Chemistry, Multidisciplinary
Iulian Zoltan Boboescu, Florian Chemarin, Jean-Baptiste Beigbeder, Bruna Rego de Vasconcelos, Rajesh Munirathinam, Thierry Ghislain, Jean-Michel Lavoie
CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY
(2019)
Article
Chemistry, Physical
Rajesh Munirathinam, Dorothee Laurenti, Denis Uzio, Gerhard D. Pirngruber
APPLIED CATALYSIS A-GENERAL
(2017)